Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts

Jurado-Fasoli, Lucas; Sanchez-Delgado, Guillermo; Alcantara, Juan M.A.; Acosta, Francisco M.; Sanchez-Sanchez, Rocio; Labayen, Idoia; Ortega, Francisco B.; Martinez-Tellez, Borja; Ruiz, Jonatan R.

doi:10.1016/j.ebiom.2023.104948

Cited by 3 publications

(1 citation statement)

References 69 publications

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“…According to the latest research, adult BAT is normally activated by cold, has a high prevalence without sexual dimorphism, and is negatively related to body fat percentage; however, it declines with age and BMI [ 35 ]. Returning to its protective role, adults with metabolically healthy overweight or obesity present higher BAT volumes and are more thermogenic compared with unhealthy obese individuals [ 36 ]. Therewith, brown adipose contributes to the enhanced consumption of glucose [ 37 ].…”

Section: Types Of Adiposementioning

confidence: 99%

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Boychenko,

Egorova,

Brovin

et al. 2024

Pharmaceuticals

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Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the influences of environment and reduced physical activity. Two types of adipose tissue widely known are white and brown. While white adipose tissue functions predominantly as a key energy storage, brown adipose tissue has a greater mass of mitochondria and expresses the uncoupling protein 1 (UCP1) gene, which allows thermogenesis and rapid catabolism. Even though white and brown adipocytes are of different origin, activation of the brown adipocyte differentiation program in white adipose tissue cells forces them to transdifferentiate into “beige” adipocytes, characterized by thermogenesis and intensive lipolysis. Nowadays, researchers in the field of small molecule medicinal chemistry and gene therapy are making efforts to develop new drugs that effectively overcome insulin resistance and counteract obesity. Here, we discuss various aspects of white-to-beige conversion, adipose tissue catabolic re-activation, and non-shivering thermogenesis.

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Section: Types Of Adiposementioning

confidence: 99%

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Boychenko,

Egorova,

Brovin

et al. 2024

Pharmaceuticals

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Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM

Bonfante,

Segantim,

Mendonça

et al. 2024

Endocrine

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Do endocrine and lipid responses to an ice bath depend on the time of day?

Braunsperger,

Bauer,

Brahim

et al. 2024

Preprint

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While the effect of time-of-day (morning versus evening) has been studied in relation to meals and exercise, there are no studies that investigate the effects of time-of-day on an ice bath. In this crossover-designed study, we recruited a homogenous group of six women and six men for an ice bath (8–12°C for 5 min) in the morning and evening. Venous blood samples were collected before and after the ice baths. Both ice baths increased plasma noradrenaline levels similarly between women and men. Adrenaline and cortisol were not affected by any of the ice baths. Plasma lipid class composition differs in the morning versus the evening and only in the morning, ice bathing is accompanied by a significantly higher fatty acid composition. The increase of noradrenaline in response to the ice bath in the morning is consistent with higher plasma concentrations of fatty acids. This relationship suggests that the time-of-day affects noradrenaline-associated lipolysis induced by an ice bath. This time-of-day effect can be further attributed to interindividual plasma fatty acid responses to a morning ice bath. Apparently, morning ice baths increase plasma fatty acids via noradrenaline-associated lipolysis more than in the evening.

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Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts

Cited by 3 publications

References 69 publications

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

Better cardiometabolic/inflammatory profile is associated with differences in the supraclavicular adipose tissue activity of individuals with T2DM

Do endocrine and lipid responses to an ice bath depend on the time of day?

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