Advance in C-H Arylation of Indoles

Abstract

The indoles motifs are widely found in the nature. One of the efficient strategy to access the indole derivatives is through the direct C-H functionalization of indole framework itself under transition-metal catalysis. Herein, the research advances on the transition-metal-catalyzed C-H arylation of indoles are reviewed.

Rh‐Catalyzed Chemo‐ and Enantioselective Hydrogenation of Allylic Hydrazones

“…The importance of these compounds in synthetic chemistry has made them an attractive target over the past few decades. Several protocols have been developed for their catalytic asymmetric synthesis . However, such approaches, including allylic amination, vinylation of imines, hydroamination of allenes and kinetic resolution, still have several problems, such as narrow substrate scope, high catalyst loading, and difficult operating procedures, that greatly limit their industrial applications.…”

Late-stage modification of complex drug: Base-controlled Pd-catalyzed regioselective synthesis and bioactivity of arylated osimertinibs

“…A great deal of effort has been devoted to the formation of C2-arylated indole via transition metal–catalyzed oxidative C─H bond activation ( 26 – 28 ). The method avoids the prefunctionalization of indoles and affords a shortcut for the arylation of indoles ( 29 ).…”

RuO2nanoparticles anchored on g-C3N4as an efficient bifunctional electrocatalyst for water splitting in acidic media

“…Its exceptional working current density, purity, and production efficiency are key attributes that make it a favored choice. [3][4][5][6] Electrochemical hydrolysis, comprising the hydrogen evolution reaction (HER) on the cathode and the oxygen evolution reaction (OER) on the anode, holds promise as a method for producing high-purity hydrogen. [7][8][9] However, the process faces a significant hurdle in practical application due to high energy consumption primarily arising from the rapidly increasing overpotential of electrolytic water with current growth.…”