Advance in hyperbaric oxygen therapy in spinal cord injury

Siglioccolo, Antonio; Gammaldi, Renato; Vicinanza, Veronica; Galardo, Alessio; Caterino, Vittorio; Palmese, Salvatore; Ferraiuoli, Carmine; Calicchio, Alessandro; Romanelli, Antonio

doi:10.1016/j.cjtee.2023.05.002

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Various diseases, such as DCI and arterial gas embolism, are directly linked with Hyperbaric Medicine. Beyond these, hyperbaric medicine can be synergistically applied with traditional therapeutic methods, offering excellent outcomes in several other conditions, including gas gangrene, ulcer healing, spinal cord injuries, and osteomyelitis [20,21]. Concurrently, although still under investigation, hyperbaric oxygen therapy shows promising potential for treating various medical disorders, such as inflammatory bowel disease, fractures with delayed healing, and severe retinal artery occlusion [22][23][24][25][26][27].…”

Section: The Future Of Diving Medicine and Its Prospectsmentioning

confidence: 99%

Diving Medicine: An Exciting Journey Through Time and Future Prospects

Lampropoulou,

Papageorgiou,

Pliakou

2024

Cureus

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Humans, led by their eternal wish to explore the unknown, have always wanted to perfect their diving skills and conquer the sea world. The adverse conditions experienced by divers brought about medical problems and a new field of medicine. Diving medicine serves the identification, treatment, and precautions against illnesses that are related to diving activities. While the development of diving equipment is advancing, divers have had the chance to reach greater depths for a longer time. Along with this success, a novel medical condition under the term ‘decompression illness’ (DCI) was introduced. Although the history of hyperbaric medicine is very long, progress in the field of mechanics has offered great contributions to the management of the disease. The first attempt at DCI guidelines was made by the US Navy in 1944-1945 and resulted in the creation of hyperbaric treatment tables. These tools received international recognition, offering a major advance. Hyperbaric-Diving Medicine holds an important place in modern medical science nowadays with indications for various diseases. At the same time, there is great scientific interest and a lot of research in the use of hyperbaric oxygen for several medical disorders, demonstrating great potential.

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Section: The Future Of Diving Medicine and Its Prospectsmentioning

confidence: 99%

Diving Medicine: An Exciting Journey Through Time and Future Prospects

Lampropoulou,

Papageorgiou,

Pliakou

2024

Cureus

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The Impact of Hyperbaric Oxygen Therapy on Functional and Structural Plasticity in Rats With Spinal Cord Injury

Yang,

Wu,

Lai

et al. 2024

Brain and Behavior

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IntroductionSpinal cord injury (SCI) can result in sensory and locomotor function loss below the injured segment. Hyperbaric oxygen therapy (HBOT) has been proven to alleviate SCI. This study aims to establish a reproducible rat model of SCI and investigate the impact of HBOT on alterations in brain neuronal activity and neuromotor function in this experimental rat SCI model using resting‐state functional magnetic resonance imaging (rs‐fMRI).MethodsThis is a prospective randomized controlled animal trial. A total number of 27 female SD rats were randomly divided into three groups: sham (n = 9), SCI (n = 9), and HBO (n = 9). rs‐fMRI was utilized to assess regional homogeneity (ReHo) values and functional connectivity (FC) strength over the whole brain with the motor cortex as seeds. Correlation between neuroimaging characteristics and behavioral assessment was calculated. We examined Nissl body, NeuN, and caspase‐3 expression in relevant brain regions.ResultsFollowing SCI, reduced ReHo values were observed in the left primary somatosensory cortex, left striatum, right agranular insular cortex, and partial cortex in the limbic system, which was reversed after HBOT. HBOT could increase FC strength between the motor cortex and other brain regions, including the left secondary motor cortex, right basal forebrain region, bilateral primary somatosensory cortex, bilateral thalamus, and another partial cortex in the limbic system. BBB scale scores showed that HBOT promoted motor function recovery in SCI rats. The ReHo and FC values in all positive clusters were positively correlated with BBB scores. By histopathological analysis, our study found that HBOT could reduce apoptotic proteins, increase the number of neurons, and protect neuronal function in brain regions with significant ReHo and FC alteration in SCI rats.ConclusionThis study reveals that HBOT facilitates functional and structural plasticity in the brain, contributing to the recovery of motor function in rats with SCI.

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Recent advances in the application of gasotransmitters in spinal cord injury

Gao,

Jin,

Zhou

et al. 2024

J Nanobiotechnol

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Spinal Cord Injury (SCI) is a condition characterized by complete or incomplete motor and sensory impairment, as well as dysfunction of the autonomic nervous system, caused by factors such as trauma, tumors, or inflammation. Current treatment methods primarily include traditional approaches like spinal canal decompression and internal fixation surgery, steroid pulse therapy, as well as newer techniques such as stem cell transplantation and brain-spinal cord interfaces. However, the above methods have limited efficacy in promoting axonal and neuronal regeneration. The challenge in medical research today lies in promoting spinal cord neuron regeneration and regulating the disrupted microenvironment of the spinal cord. Studies have shown that gas molecular therapy is increasingly used in medical research, with gasotransmitters such as hydrogen sulfide, nitric oxide, carbon monoxide, oxygen, and hydrogen exhibiting neuroprotective effects in central nervous system diseases. The gas molecular protect against neuronal death and reshape the microenvironment of spinal cord injuries by regulating oxidative, inflammatory and apoptotic processes. At present, gas therapy mainly relies on inhalation for systemic administration, which cannot effectively enrich and release gas in the spinal cord injury area, making it difficult to achieve the expected effects. With the rapid development of nanotechnology, the use of nanocarriers to achieve targeted enrichment and precise control release of gas at Sites of injury has become one of the emerging research directions in SCI. It has shown promising therapeutic effects in preclinical studies and is expected to bring new hope and opportunities for the treatment of SCI. In this review, we will briefly outline the therapeutic effects and research progress of gasotransmitters and nanogas in the treatment of SCI. Graphical Abstract

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Advance in hyperbaric oxygen therapy in spinal cord injury

Cited by 4 publications

References 34 publications

Diving Medicine: An Exciting Journey Through Time and Future Prospects

Diving Medicine: An Exciting Journey Through Time and Future Prospects

The Impact of Hyperbaric Oxygen Therapy on Functional and Structural Plasticity in Rats With Spinal Cord Injury

Recent advances in the application of gasotransmitters in spinal cord injury

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