Advance in quality assessment of Chinese materia medica using microscopic and morphological methods

Miao, Xiao-Su; Cui, Qingyu; Wang, Zhaoyi; Liu, Xiaona; Zhao, Anbang; Qiao, Yanjiang; Wu, Zhisheng

doi:10.1016/s1875-5364(17)30094-8

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…At present, the main identification techniques of traditional Chinese medicine include sensory evaluation, microscopic identification [41], physical and chemical identification, and molecular identification [42]. One of the traditional identification methods, thin-layer chromatography, can distinguish K. praeruptora, Angelica decursiva (Miquel) Franchet & Sa-vatier, and S. divaricata through the number of thin-layer fluorescent spots, color, and Rf value [43].…”

Section: Identificationmentioning

confidence: 99%

A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov

Wang,

Ding,

Wang

et al. 2023

Molecules

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Kitagawia praeruptora (Dunn) Pimenov, commonly known as Qianhu in China, is a widely used folk Chinese herbal medicine. This article reviews its botanical traits, ethnopharmacology, cultivation techniques, identification, phytochemical compositions, and pharmacological effects. Over 70 coumarin compounds, including simple coumarins, pyranocoumarins, and furanocoumarins, have been isolated within this plant. Additionally, K. praeruptora contains other components such as flavonoids, fatty acids, benzoic acids, and sterols. This information highlights the importance of utilizing active ingredients and excavating pharmacological effects. With its remarkable versatility, K. praeruptora exhibits a wide range of pharmacological effects. It has been found to possess expectorant and bronchodilator properties, cardiovascular protection, antimicrobial and antioxidant activities, anti-tumor effects, and even antidiabetic properties. It is recommended to focus on the development of new drugs that leverage the active ingredients of K. praeruptora and explore its potential for new clinical applications and holistic utilization.

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Section: Identificationmentioning

confidence: 99%

A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov

Wang,

Ding,

Wang

et al. 2023

Molecules

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“…At present, the identification methods for Radix Bupleuri and its adulterants include character identification ( Editorial Committee of Chinese Pharmacopoeia, 2020 ), DNA barcode identification ( Feng et al, 2015 ), TLC identification ( Yen et al, 1991 ), HPLC identification ( Qian, 2012 ), and microscopic identification ( Miao et al, 2017 ). Existing identification methods have their advantages and disadvantages: character identification is simple but requires rich knowledge of traditional Chinese medicine identification; DNA barcode identification, thin-layer chromatography identification, HPLC identification, and microscopic identification features high accuracy, but the operation is too complicated.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study on the introduction of Micro-CT technology for the identification of Radix Bupleuri and its adulterants

Chen,

Zhuang

et al. 2024

Front. Pharmacol.

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Background:Radix Bupleuri, a kind of Chinese herbal medicine with great clinical use, is often confused with its adulterants, and it is difficult to identify it without certain knowledge. The existing identification methods have their own drawbacks, so a new method is needed to realize the identification of Radix Bupleuri and its adulterants.Methods: We used Micro Computed Tomography (Micro-CT) to perform tomography scans on Radix Bupleuri and its adulterants, performed data screening and data correction on the obtained DICOM images, and then applied 3D reconstruction, data augmentation, and ResNext deep learning model for the classification study.Results: The DICOM images after data screening, data correction, and 3D reconstruction can observe the differences in the microstructure of Radix Bupleuri and its adulterants, thus enabling effective classification and analysis. Meanwhile, the accuracy of classification using the ResNext model reached 75%.Conclusion: The results of this study showed that Micro-CT technology is feasible for the authentication of Radix Bupleuri. The pre-processed and 3D reconstructed tomographic images clearly show the microstructure and the difference between Radix Bupleuri and its adulterants without damaging the internal structure of the samples. This study concludes that Micro-CT technology provides important technical support for the reliable identification of Radix Bupleuri and its adulterants, which is expected to play an important role in the quality control and clinical application of herbs.

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“…Therefore, the quality evaluation of D. officinale is essential. Conventional approaches for identifying D. officinale mainly encompass morphological identification [11], fingerprinting [12], and chemical analysis [3]. However, character identification and fingerprinting are inclined to yield insensitive detection results.…”

Section: Introductionmentioning

confidence: 99%

Rapid Measurement of Total Saponins, Mannitol, and Naringenin in Dendrobium officinale by Near-Infrared Spectroscopy and Chemometrics

She,

Huang,

Cao

et al. 2024

Foods

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Dendrobium officinale has drawn increasing attention as a dual-use plant with herbal medicine and food applications. The efficient quality evaluation of D. officinale is essential to ensuring its nutritional and pharmaceutical value. Given that traditional analytical methods are generally time-consuming, expensive, and laborious, this study developed a rapid and efficient approach to assess the quality of D. officinale from different geographical origins by near-infrared (NIR) spectroscopy and chemometrics. Total saponins, mannitol, and naringenin were utilized as quality indicators. Two wavelength selection methods, namely, uninformative variable elimination and competitive adaptive reweighted sampling (CARS), were utilized to enhance the prediction accuracy of the quantification model. Moreover, multiple spectral pretreatment methods were applied for model optimization. Results indicated that the partial least squares (PLS) model constructed based on the wavelengths selected by CARS exhibited superior performance in predicting the contents of the quality indicators. The coefficient of determination (RP2) and root mean square error (RMSEP) in the independent test sets were 0.8949 and 0.1250 g kg−1 for total saponins, 0.9664 and 0.2192 g kg−1 for mannitol, and 0.8570 and 0.003159 g kg−1 for naringenin, respectively. This study revealed that NIR spectroscopy and the CARS-PLS model could be used as a rapid and accurate technique to evaluate the quality of D. officinale.

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Advance in quality assessment of Chinese materia medica using microscopic and morphological methods

Cited by 5 publications

References 16 publications

A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov

A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology of Kitagawia praeruptora (Dunn) Pimenov

Feasibility study on the introduction of Micro-CT technology for the identification of Radix Bupleuri and its adulterants

Rapid Measurement of Total Saponins, Mannitol, and Naringenin in Dendrobium officinale by Near-Infrared Spectroscopy and Chemometrics

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