Advance in the pharmacological and comorbidities management of heart failure with preserved ejection fraction: evidence from clinical trials

Meifang, Wu; Wang, Ying; Chen, Wen; Xu, Kang; Song, Meiyan; L, Lin

doi:10.1007/s10741-023-10338-x

Heart Fail Rev

2023

DOI: 10.1007/s10741-023-10338-x

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Advance in the pharmacological and comorbidities management of heart failure with preserved ejection fraction: evidence from clinical trials

Wu Meifang

Ying Wang

Wen Chen

et al.

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Cited by 3 publications

References 149 publications

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The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review

Widiarti,

Saputra,

Ariyanto

et al. 2024

Curr Cardiol Rep

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Background Acute decompensated heart failure (ADHF) patients with symptomatic congestion often require in-hospital admission for intravenous (IV) diuretic, impacting both patient well-being and healthcare expenses. Subcutaneous (SC) furosemide has a potential to facilitate outpatient management of ADHF patients. Thus, this study aims to assess the efficacy and safety of SC furosemide utilization, offering a potential alternative to traditional IV administration. Methods A systematic search was conducted until April 14 2024 across scientific databases. This review included studies comparing SC furosemide with oral and IV formulations in adult HF patients. Results This study analyzed 687 patients from 20 studies. The results demonstrate that SC furosemide can effectively manage symptomatic congestion in HF patients and results in significant cost reductions, symptom relief, and improved quality of life. Although further investigation into mortality rates is needed, SC furosemide demonstrates efficacy comparable to IV furosemide in diuresis and weight loss, with similar bioavailability and natriuretic effects. Adverse events are generally minor, predominantly related to skin irritation. Innovative strategies, such as developing isotonic alkaline solutions and improved infusion devices, are being explored to address these challenges. Conclusion SC furosemide offers a promising alternative for managing ADHF, particularly in symptomatic HF patients with volume overload. The integration of SC furosemide into routine clinical practice and future guidelines, could optimize the management of HF, reducing hospital admission and improving patient outcomes.

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The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review

Widiarti,

Saputra,

Ariyanto

et al. 2024

Curr Cardiol Rep

View full text Add to dashboard Cite

show abstract

Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial

Edelmann,

Wachter,

Duvinage

et al. 2025

Nat Med

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Targeting obesity for therapeutic intervention in heart failure patients

Sato,

von Haehling

2024

Expert Review of Cardiovascular Therapy

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Advance in the pharmacological and comorbidities management of heart failure with preserved ejection fraction: evidence from clinical trials

Cited by 3 publications

References 149 publications

The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review

The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review

Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial

Targeting obesity for therapeutic intervention in heart failure patients

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