Advance of the negative regulation of anthocyanin biosynthesis by MYB transcription factors

Chen, Linhuan; Hu, Bing; Qin, Yonghua; Hu, Guibing; Zhao, Jiamin

doi:10.1016/j.plaphy.2019.01.024

Cited by 193 publications

(159 citation statements)

References 73 publications

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“…In particular, R2R3MYBs from SG4 can join an activating MBW complex and turn it into one that represses target gene transcription, and R3MYBs can bind the bHLH to prevent it from forming the MBW complex, thus competitively inhibiting activation (Albert et al, 2014). The SG4 R2R3MYBs are characterized by the presence of an ethylene response factor (ERF)-associated amphiphilic repression (EAR) motif (LxLxL or DLNxxP) or a TLLLFR motif in the C terminus that mediates transcriptional repression (Chen et al, 2019a;Chen et al, 2019b;Ma and Constabel, 2019). For the activation of the flavonol and flavone branches, a SG7 R2R3MYB acts without being part of the complex.…”

Section: Evolution Of the Transcriptional Regulation Of The Phenylpromentioning

confidence: 99%

The Evolution of Flavonoid Biosynthesis: A Bryophyte Perspective

et al. 2020

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The flavonoid pathway is one of the best characterized specialized metabolite pathways of plants. In angiosperms, the flavonoids have varied roles in assisting with tolerance to abiotic stress and are also key for signaling to pollinators and seed dispersal agents. The pathway is thought to be specific to land plants and to have arisen during the period of land colonization around 550-470 million years ago. In this review we consider current knowledge of the flavonoid pathway in the bryophytes, consisting of the liverworts, hornworts, and mosses. The pathway is less characterized for bryophytes than angiosperms, and the first genetic and molecular studies on bryophytes are finding both commonalities and significant differences in flavonoid biosynthesis and pathway regulation between angiosperms and bryophytes. This includes biosynthetic pathway branches specific to each plant group and the apparent complete absence of flavonoids from the hornworts.

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Section: Evolution Of the Transcriptional Regulation Of The Phenylpromentioning

confidence: 99%

The Evolution of Flavonoid Biosynthesis: A Bryophyte Perspective

et al. 2020

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“…In many plant species, subgroup 4 R2R3 MYBs of the FaMYB1-like clade are involved in the regulation of the flavonoid pathway, including the anthocyanin branch [29,30]. Because PbMYB120 showed high homology to FaMYB1, it was considered as a potential regulator of anthocyanin biosynthesis ( Figure 1A).…”

Section: Pbmyb120's Expression Pattern Positively Correlated With Antmentioning

confidence: 99%

“…The subgroup 4 R2R3 MYBs have been phylogenetically classified into the AtMYB4-like and FaMYB1-like clades [29,37]. The AtMYB4-like clade's members are mainly involved in the regulation of the general phenylpropanoid pathway and the lignin-branched pathway, while the FaMYB1-like clade's members are mainly involved in the regulation of the flavonoid-branched pathway [29,30,37].…”

Section: Roles Of the Subgroup 4 R2r3 Mybs In The Regulation Of Anthomentioning

confidence: 99%

“…However, a complex mechanism is involved in the negative regulation of anthocyanin biosynthesis by MYB repressors [29,37]. Reviews on the anthocyanin biosynthesis suggest that FaMYB1-like anthocyanin repressors may generally exert their functions in indirect ways by interfering with the interaction and assembly of MYB and bHLH members in the MBW activation complex, and thus repress the transcriptional activity of the MBW activation complex [29,30]. Some AtMYB4-like repressors can also repress anthocyanin biosynthesis, and they generally exert their functions in direct ways.…”

Section: Mechanisms Of Subgroup 4 R2r3 Myb Repressors In Anthocyanin mentioning

confidence: 99%

“…For example, apple (Malus × domestica) MYB16 directly binds MdANS and MdUFGT, and inhibits their expression through the C-terminal EAR motif. AtMYB3 inhibits the biosynthesis of sinapoyl malate and anthocyanin directly by targeting and repressing AtC4H [29,41,42].…”

Section: Mechanisms Of Subgroup 4 R2r3 Myb Repressors In Anthocyanin mentioning

confidence: 99%

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PbMYB120 Negatively Regulates Anthocyanin Accumulation in Pear

Song

Wang

Han

et al. 2020

IJMS

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Subgroup 4 R2R3 MYBs play vital roles in the regulation of anthocyanin biosynthesis. However, there is limited knowledge regarding the functions of MYB repressors in pear (Pyrus × bretschneideri). Here, PbMYB120 was identified as a potential regulator of anthocyanin biosynthesis. A phylogenetic analysis revealed that PbMYB120 was clustered into the FaMYB1-like clade of the subgroup 4 R2R3 MYBs. PbMYB120 was expressed higher in red peels than in green peels in five pear cultivars. PbMYB120 expression was positively correlated with anthocyanin accumulation. However, the transient overexpression of PbMYB120 led to the inhibition of anthocyanin accumulation and PbUFGT1 expression. Promoter binding and activation assays indicated that PbMYB120 binds to the promoter of PbUFGT1 and represses the promoter’s activity. Thus, the inhibition of anthocyanin accumulation by PbMYB120 may be correlated with the repression of PbUFGT1. Furthermore, during anthocyanin induction, the expression levels of anthocyanin activators and PbMYB120 were upregulated. This study demonstrated that PbMYB120 was highly expressed in pear tissues having higher anthocyanin accumulations but acted as a repressor in the regulation of anthocyanin accumulation. PbMYB120 may work coordinately with anthocyanin activators and serve as a balancer of anthocyanin accumulation.

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A Long and Winding Road

Martin

Albert

2023

Recent Advances in Polyphenol Research

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Advance of the negative regulation of anthocyanin biosynthesis by MYB transcription factors

Cited by 193 publications

References 73 publications

The Evolution of Flavonoid Biosynthesis: A Bryophyte Perspective

The Evolution of Flavonoid Biosynthesis: A Bryophyte Perspective

PbMYB120 Negatively Regulates Anthocyanin Accumulation in Pear

A Long and Winding Road

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