Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Yavuz, Bünyamin; Sener, Dede D.; Cankurtaran, Mustafa; Halil, Meltem; Ülger, Zekeriya; Nazli, Nasıh; Kabakçı, Giray; Aytemir, Kudret; Tokgözoğlu, Lâle; Oto, Ali̇; Arıoğul, Servet

doi:10.1159/000129064

Cited by 54 publications

(45 citation statements)

References 35 publications

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“…Brachial artery reactivity, frequently used for non-invasive ultrasonographic assessment of FMD, indicates endotheliumdependent response to increased wall shear stress and when impaired is a marker for endothelial dysfunction and increased cardiovascular risk, correlating with impaired endothelium-dependent relaxation in the coronary arteries (Takase et al 1998;Matsuo et al 2004;Thanyasiri et al 2005). In agreement with previous results (Yavuz et al 2008), the measurement of endothelial-dependent vasodilatation in our old-aged population has evidenced that FMD declines with increasing age (Figs. 1 and 2) and we could confirm that advanced age is a predictor of impaired endothelial function in human subjects.…”

Section: Resultssupporting

confidence: 91%

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

Mazzoccoli

Fontana

Grilli

et al. 2011

AGE

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Arterial and venous thrombosis have always been regarded as different pathologies and epidemiological studies have examined the association between venous thrombosis and indicators of atherosclerosis and/or arterial thromboembolic events. We measured the flow-mediated dilation (FMD), a well-known marker of arterial endothelial dysfunction, in youngmiddle-aged and old-aged patients with and without unprovoked deep venous thrombosis (DVT). The aim of this study was to investigate whether DVT was a significant predictor for impaired FMD, considering all the patients and young-middle-aged (age<65 years) and old-aged (age≥65 years) patients separately. FMD was measured in the brachial artery on a population of 120 subjects with the same atherosclerosis risk factors, 68 male and 52 female, 70 young-middleaged subjects (mean age±SD 49.5±10.5 years) and 50 old-aged subjects (76.2±7.7 years). Patients with DVT showed a significant decrease of FMD compared to patients without DVT (6.8±5.5% vs. 10.9±3.5%, p<0.001). Moreover, old-aged patients showed a significant decrease of FMD compared to the young-middle-aged subjects (7.4±4.1% vs. 9.8± 5.3%, p=0.005). In the whole study population, DVT was strongly associated with FMD (risk factors adjusted β=−4.14, p<0.001). A significant interaction between age and the presence of DVT on predicting FMD was found (p=0.003) suggesting a AGE (2012) differential behavior of DVT as predictor of FMD. In young-middle-aged group, multivariate model confirmed that DVT was the most significant predictor of continuous FMD (β=−6.06, p<0.001). On the contrary, DVT was no more a predictor of FMD in the old age group (β=−0.73, p=0.556). Furthermore, old-aged patients without DVT showed a statistically significant decrease of FMD compared to the youngmiddle-aged subjects without DVT (8.2±2.1% vs. 12.6±2.7%, p<0.001) and old-aged patients with DVT showed a not statistically significant decrease of the FMD compared to the young-middle-aged patients with DVT (6.7±5.3% vs. 6.8±5.7%, p= 0.932). In conclusion, young-middle-aged patients with spontaneous DVT show an impaired FMD, whereas this impairment in old-aged subjects is evident independently from the presence or absence of DVT. Aging per se may be associated with physiologic abnormalities in the systemic arteries and with endothelial dysfunction.34:751-760 DOI 10.1007/s11357-011-9265-

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Section: Resultssupporting

confidence: 91%

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

Mazzoccoli

Fontana

Grilli

et al. 2011

AGE

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“…Individual r 2 value and variance inflation factor (VIF) explain how well each independent variable is predicted from the other variables effects of reduced arterial compliance with age. However, some reports suggest that FMD impairment predicts endothelial dysfunction, despite the aging process [28,29]. Very recently our group, by using the FMD technique, demonstrated a association of metabolic syndrome (MetS) and endothelium dysfunction in a aged population, suggesting that the altered vasodilation in aged people affected by MetS mainly depends on endothelial dysfunction [15].…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction associated with mild cognitive impairment in elderly population

et al. 2013

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“…There is a risk of isolated systolic hypertension or diastolic heart failure. 9,10 Ageing also significantly affects the central nervous system (CNS). Cerebral perfusion decreases by 15-20 % in the elderly.…”

Section: Anti-hypertensive Treatment In Elderly Patientsmentioning

confidence: 99%

Hypertension and Frailty Syndrome in Old Age: Current Perspectives

Uchmanowicz

Chudiak

Jankowska‐Polańska

et al. 2017

Cardiac Failure Review

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Hypertension is considered the most common disorder in the general population. It is both a health and a financial problem worldwide.The Writing Group of the American Society of Hypertension defines hypertension as a cardiovascular syndrome resulting from a number of interconnected factors. 1 Therefore, a comprehensive evaluation is required, involving both the cardiovascular system and other risk factors. In the global population, the prevalence of hypertension is 26.4 %, which is expected to increase to one-third of the population by 2025. 2 The elderly comprise a special group of hypertensive patients because of ageing-related processes. In accordance with data from the Framingham study, 58.9 % of people aged ≥65 and 70 % of those aged ≥80 years are hypertensive. 3 Most patients in the group have isolated systolic hypertension, with normal diastolic blood pressure (DBP) valuesbelow 90 mmHg. In the elderly population, systolic blood pressure (SBP) is a more significant risk factor for cardiovascular complications than DBP. Chronic high SBP leads to left ventricular hypertrophy, as decreased elasticity of large blood vessels -particularly the aortaputs extra strain on the heart. 4 The ageing process involves a number of changes contributing to the development of hypertension. Besides decreased blood vessel elasticity, these include increased collagen content in the extracellular matrix, decreased numbers of elastic fibres, increased vessel wall thickness, and decreased vessel lumen.In the elderly, the lower number of elastic fibres in the vessel wall contributes to increased SBP. AbstractHypertension is both a health problem and a financial one globally. It affects nearly 30 % of the general population. Elderly people, aged ≥65 years, are a special group of hypertensive patients. In this group, the overall prevalence of the disease reaches 60 %, rising to 70 % in those aged ≥80 years. In the elderly population, isolated systolic hypertension is quite common. High systolic blood pressure is associated with an increased risk of cardiovascular disease, cerebrovascular disease, peripheral artery disease, cognitive impairment and kidney disease. Considering the physiological changes resulting from ageing alongside multiple comorbidities, treatment of hypertension in elderly patients poses a significant challenge to treatment teams. Progressive disability with regard to the activities of daily life, more frequent hospitalisations and low quality of life are often seen in elderly patients. There is discussion in the literature regarding frailty syndrome associated with old age. Frailty is understood to involve decreased resistance to stressors, depleted adaptive and physiological reserves of a number of organs, endocrine dysregulation and immune dysfunction. The primary dilemma concerning frailty is whether it should only be defined on the basis of physical factors, or whether psychological and social factors should also be included. Proper nutrition and motor rehabilitation should be prioritised in care for frail pa...

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Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects

Cited by 54 publications

References 35 publications

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

Endothelial dysfunction associated with mild cognitive impairment in elderly population

Hypertension and Frailty Syndrome in Old Age: Current Perspectives

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