Advanced analysis and applications of single-cell transcriptome sequencing

Zhao, Ruo-Han; Yicheng, Bai; Zhao, Jing; Hu, Mei; Zhang, Xinyan; Yang, Min; Dou, Tengfei; Jia, Junjing

doi:10.1080/26895293.2023.2199140

All Life

2023

DOI: 10.1080/26895293.2023.2199140

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Advanced analysis and applications of single-cell transcriptome sequencing

Ruo-Han Zhao

Bai Yicheng

Jing Zhao

et al.

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2024

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Cited by 1 publication

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Single-Cell RNA Sequencing and Its Applications in Pituitary Research

Yang,

Deng,

et al. 2024

Neuroendocrinology

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Mounting evidence underscores the significance of cellular diversity within the endocrine system and the intricate interplay between different cell types and tissues, essential for preserving physiological balance and influencing disease trajectories. The pituitary gland, a central player in the endocrine orchestra, exemplifies this complexity with its assortment of hormone-secreting and non-secreting cells. It houses several types of pituitary cells responsible for hormone production, alongside non-secretory cells like fibroblasts and endothelial cells, each playing a crucial role in the gland's function and regulatory mechanisms. Despite the acknowledged importance of these cellular interactions, the detailed mechanisms by which they contribute to pituitary gland physiology and pathology remain largely uncharted. The last decade has seen the emergence of groundbreaking technologies such as single-cell RNA sequencing, offering unprecedented insights into cellular heterogeneity and interactions. However, the application of this advanced tool in exploring the pituitary gland's complexities has been scant. This review offers an overview of this methodology, highlighting its strengths and limitations, discussing the future possibilities for employing it in deepening our understanding of the pituitary gland and its dysfunction in disease states.

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Single-Cell RNA Sequencing and Its Applications in Pituitary Research

Yang,

Deng,

et al. 2024

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

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Advanced analysis and applications of single-cell transcriptome sequencing

Cited by 1 publication

References 102 publications

Single-Cell RNA Sequencing and Its Applications in Pituitary Research

Single-Cell RNA Sequencing and Its Applications in Pituitary Research

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