High-mesa semi-insulating buried heterostructure (SIBH) lasers with InP: Fe have great potential in high-speed and high-power scenarios, but the leakage current problem under high current injections has always limited their application. In order to solve the issue of low output power and low efficiency for high-mesa SIBH lasers, the mechanism of leakage current generation in InP-based semi-insulating (SI) layers at high injection levels was analyzed through numerical simulation. The deterioration of the device performance is due to the hole current-induced electron leakage current, which results from the reduction of the potential barrier and Fe-Zn interdiffusion. Thus, lasers with wide bandgap layers of InAlAs and ZnCdSe were employed for current blocking, the power and wall-plug efficiency of which were improved by more than 36% and 5%, respectively. For the first time, a SIBH laser based on lattice-matched ZnCdSe barrier layers is proposed, which shows good output performance and high reliability. The introduction of the wide bandgap layer in the SIBH structure establishes potential barriers to confine both carrier leakages at high injection levels, which realizes the high-power and high-efficiency operation of the laser.