Advanced bioactive nanomaterials for biomedical applications

Abstract

Bioactive materials are a kind of materials with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. Bioactive materials came into the spotlight in the late 1960s when the researchers found that the materials such as bioglass could react with surrounding bone tissue for bone regeneration. In the following decades, advances in nanotechnology brought the new development opportunities to bioactive nanomaterials. Bioactive nanomaterials are not a simple miniaturization of macroscopic materials. They exhibit unique bioactivities due to their nanoscale size effect, high specific surface area, and precise nanostructure, which can significantly influence the interactions with biological systems. Nowadays, bioactive nanomaterials have represented an important and exciting area of research. Current and future applications ensure that bioactive nanomaterials have a high academic and clinical importance. This review summaries the recent advances in the field of bioactive nanomaterials, and evaluate the influence factors of bioactivities. Then, a range of bioactive nanomaterials and their potential biomedical applications are discussed. Furthermore, the limitations, challenges, and future opportunities of bioactive nanomaterials are also discussed.

A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms

“…Bacterial wound infection generally not only prolongs wound healing, but also may cause other serious problems, such as systemic infections, sepsis, organ failure, and even death [ [1] , [2] , [3] ]. Although the advent of antibiotics has slowed the progression of bacterial infections to some extent, the overuse of antibiotics has led to the emergence of antibiotic-resistant strains of pathogenic bacteria that are increasingly spreading in communities and hospitals [ 4 , 5 ].…”

A new polysaccharide platform constructs self-adjuvant nanovaccines to enhance immune responses

“…For decades, researchers have devoted to use natural polysaccharides as building blocks to construct diverse functional biomaterials [ 34 – 36 ]. Amounts of active groups (hydroxyl, amidogen and sulfydryl) can endow polysaccharides with convenient modifications on the surface or the interior of bio-scaffolds to formulate various functional derivatives for the applications [ 37 , 38 ] of soft tissue engineering engineering [ 39 , 40 ] and delivery carriers [ 41 – 43 ]. Moreover, most of polysaccharides-based constructions or modifications have been performed in mild and nontoxic aqueous environments.…”

A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing

“…Therefore, developing an effective coagulation and anti-infection strategy is urgently needed to rescue patients suffering from wound or trauma, especially sufferer with the coagulation disorders and poor immunity ( Mofazzal Jahromi et al, 2018 ; Wang et al, 2020 ). Towards this end, although there have been numerous successful efforts using hemostatic and antibacterial biomaterials ( Zhao et al, 2021 ), it remains a challenge to develop ideal and clinical multifunctional materials to control bleeding and prevent bacterial infection simultaneously with favorable biosecurity.…”