Advanced Biosensing Methodologies for Ultrasensitive Detection of Human Coronaviruses

Mahapatra, Sebabrata; Baranwal, Anupriya; Purohit, Buddhadev; Roy, Sharmili; Mahto, Sanjeev Kumar; Chandra, Pranjal

doi:10.1007/978-981-15-6006-4_2

Cited by 13 publications

(6 citation statements)

References 83 publications

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“…In late 2019, the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the COVID-19 pandemic that has drastically impacted the human population, leaving the world clueless, and in an unimaginable situation. PCR, which detects the viral RNA, and serological screening by detecting antibodies generated in response to the infection, are the two primary screening procedures for confirming SARS-CoV-2 [ 125 , 126 , 127 , 128 ]. However, new methods are urgently needed due to the detection complexity, expense, and relatively longer analysis period of the present approaches.…”

Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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“…Although there is a widespread use of spectroscopic and chromatographic techniques for small-molecule characterizations, sample clean-up, such as solid-phase extraction, is frequently required [ 86 ]. Sample preparation processes are laborious and require laboratory-based devices, costly, and time-consuming, limiting their utility [ 87 , 88 , 89 ].…”

Section: Small-molecule Detection Using Metallic Nanodendrite-based S...mentioning

confidence: 99%

Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

et al. 2022

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Metallic dendrites, a class of three-dimensional nanostructured materials, have drawn a lot of interests in the recent years because of their interesting hierarchical structures and distinctive features. They are a hierarchical self-assembled array of primary, secondary, and terminal branches with a plethora of pointed ends, ridges, and edges. These features provide them with larger active surface areas. Due to their enormous active areas, the catalytic activity and conductivity of these nanostructures are higher as compared to other nanomaterials; therefore, they are increasingly used in the fabrication of sensors. This review begins with the properties and various synthetic approaches of nanodendrites. The primary goal of this review is to summarize various nanodendrites-engineered biosensors for monitoring of small molecules, macromolecules, metal ions, and cells in a wide variety of real matrices. Finally, to enlighten future research, the limitations and future potential of these newly discovered materials are discussed.

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“…50 ■ BIOSENSOR TECHNOLOGY FOR THE DETECTION OF SARS-COV-2 Standard Biosensors. Biosensors have been used to detect different types of viruses, including human coronavirus, 51 HIV, 52 hepatitis virus, 53 Zika virus, 54 and various influenza viruses. 55 Biosensor technology can also be applied for efficient and reliable detection of SARS-CoV-2 and its variants.…”

Section: T H I S C O N T E N T I S O N L Y L I C E N S E D F O R C O ...mentioning

confidence: 99%

Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2

Jiang

Juhas

et al. 2021

ACS Omega

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COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has become the world’s largest public health emergency of the past few decades. Thousands of mutations were identified in the SARS-CoV-2 genome. Some mutants are more infectious and may replace the original strains. Recently, B.1.1.7(Alpha), B1.351(Beta), and B.1.617.2(Delta) strains, which appear to have increased transmissibility, were detected. These strains accounting for the high proportion of newly diagnosed cases spread rapidly over the world. Particularly, the Delta variant has been reported to account for a vast majority of the infections in several countries over the last few weeks. The application of biosensors in the detection of SARS-CoV-2 is important for the control of the COVID-19 pandemic. Due to high demand for SARS-CoV-2 genotyping, it is urgent to develop reliable and efficient systems based on integrated multiple biosensor technology for rapid detection of multiple SARS-CoV-2 mutations simultaneously. This is important not only for the detection and analysis of the current but also for future mutations. Novel biosensors combined with other technologies can be used for the reliable and effective detection of SARS-CoV-2 mutants.

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Advanced Biosensing Methodologies for Ultrasensitive Detection of Human Coronaviruses

Cited by 13 publications

References 83 publications

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Nano-Engineered Surface Comprising Metallic Dendrites for Biomolecular Analysis in Clinical Perspective

Multiplex Biosensing for Simultaneous Detection of Mutations in SARS-CoV-2

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