Advanced Catalytic Syntheses of 1,3-Oxazine Derivatives via Electrophilic Substitution Using Mono- and Bimetallic Phosphate Catalysts: Co₃(PO 4 ) 2 and CoCa 3 (HPO 4 )(PO 4 ) 2 (OH)
Achraf El hallaoui,
Nouhaila FERRAA,
Yousssef MERROUN
et al.
Abstract:This research introduces a novel catalytic approach for the synthesis of 1,3-oxazinone derivatives through a multicomponent reaction that relies on an electrophilic substitution mechanism, employing two cobalt-based phosphate catalysts. This approach, allowed us to synthesize oxazine derivatives, known for their significant biological activities, achieving impressive yields of up to 97% in a remarkably short time of only 7 minutes, all under conditions environmentally friendly according to the principles of gr… Show more
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