Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases

Iskander, John K.; Kelada, Peter; Rashad, Lara; Massoud, Doaa; Afdal, Peter; AbdelMassih, Antoine

doi:10.1016/j.cpcardiol.2021.100847

Cited by 12 publications

(10 citation statements)

References 166 publications

(156 reference statements)

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“…However, it gradually gained popularity as a global tool, that can diagnose early dysfunction in systemic disease, particularly in cardio-oncology. [5] Our case series revives the segmental power of STE and shows that it can differentiate pericarditis from myocarditis without resorting to costly and lengthy CMR.…”

Section: Discussionmentioning

confidence: 77%

Case Series of Mild Myocarditis: The Role of Speckle Tracking Echocardiography in Detecting a Patchy Disease

AbdelMassih,

Khan,

Majichian

et al. 2024

Preprint

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There is increasing evidence that myocarditis starts as a patchy process, accordingly, the detection of segmental affection is important for early recognition of the disease and proper initiation of anti-inflammatory treatment. We present our first experience here with using speckle-tracking echocardiography to detect subtle segmental involvement of the left ventricle in two cases with suspected myocarditis. STE consolidated the diagnosis and helped with the early initiation of intravenous immunoglobulins and subsequent control of the disease. STE was also able to show the specific topography of distribution, of each pathogen linked to inflammation.

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Section: Discussionmentioning

confidence: 77%

Case Series of Mild Myocarditis: The Role of Speckle Tracking Echocardiography in Detecting a Patchy Disease

AbdelMassih,

Khan,

Majichian

et al. 2024

Preprint

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“…Furthermore, the evaluation of diastolic function and the STE-GLS analysis were performed only in a subset of the participants. Regarding the limitations of the echocardiographic methods used in the study, M-mode echocardiography is limited by angle-dependency, while the main limitation of STE is intervendor variability [ 50 , 51 ]. Moreover, interobserver and intraobserver variability were not assessed in our study.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, interobserver and intraobserver variability were not assessed in our study. Additionally, although, GLS is a very sensitive indicator of ventricular injury and is the most commonly used STE parameter in clinical practice, STE analysis was limited only in the evaluation of systolic function with longitudinal cardiac deformation assessment (GLS) and global circumferential and radial strain were not assessed [ 50 ]. Finally, we did not perform GLS with Cardiac Magnetic Resonance (CMR) imaging for comparison with the 2D-Ultrasound GLS results.…”

Section: Resultsmentioning

confidence: 99%

Longitudinal Cardiac Evaluation of Children with Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 by Conventional and Speckle-Tracking Echocardiography

Anagnostopoulou,

Dourdouna,

Loukopoulou

et al. 2024

Pediatr Cardiol

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Multisystem inflammatory syndrome in children (MIS-C), is a rare but severe, hyperinflammatory complication of COVID-19, in which cardiovascular abnormalities are frequently detected. In this prospective study, we describe the echocardiographic findings in patients with MIS-C, with the use of conventional Echocardiography and Speckle-Tracking Echocardiography (STE) with Left Ventricular (LV) Global Longitudinal Strain (GLS) analysis, in the acute and follow-up phase. In total, 25 MIS-C patients [64% females, mean (± SD) age: 8.3 (± 3.72) years] were included. In the acute phase, median (IQR) Troponin and NT-proBNP and mean heart rate, were 8.07 (14.52) pg/mL, 2875.00 (7713.00) pg/mL, and 102.87 (± 22.96) bpm, respectively. Median (IQR) LV Ejection Fraction (LVEF) was 66 (8)% and LVEF impairment was detected in 2/25 (8%) patients. On follow-up (mean time interval:9.50 ± 4.59 months), heart rate was significantly lower, with a mean value of 90.00 (± 14.56) bpm (p-value = 0.017). Median (IQR) LVEF was 66.00 (6.70)% (p-value = 0.345) and all 25 participants had normal LVEF. In 14/25 patients, additional LV-GLS analysis was performed. During the acute phase, mean LV-GLS was − 18.02 (± 4.40)%. LV-GLS was abnormal in 6/14 patients (42.9%) and among them, only one patient had reduced LVEF. On follow-up (median (IQR) time interval:6.93 (3.66) months), mean LV-GLS was -20.31 (± 1.91)% (p-value = 0.07) and in 1/14 patient (7.1%), the LV-GLS impairment persisted. In conclusion, in the acute and follow-up phase, we detected abnormal LV-GLS values in some patients, in the presence of normal LVEF, indicating that STE-GLS is a valuable tool for identifying subclinical myocardial injury in MIS-C.

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“…Despite the lack of massive evidence on patient selection, treatment efficacy, and economic impact, screening for subclinical left ventricular dysfunction in metabolic disease enables cardioprotective therapy to be implemented at an early stage to prevent or delay the progression of heart failure [ 8 ]. Such screening is expected to be increasingly feasible with miniaturized echocardiography equipment and automated analysis [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Fat Mass is Associated with Subclinical Left Ventricular Systolic Dysfunction in Patients with Type 2 Diabetes Mellitus Without Established Cardiovascular Diseases

et al. 2023

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Introduction Left ventricular global longitudinal strain (GLS) is considered to be the first marker of diabetes mellitus-related subclinical cardiac dysfunction, but whether it is attributable to fat mass and distribution remains uncertain. In this study, we explored whether fat mass, especially fat mass in the android area, is associated with subclinical systolic dysfunction before the onset of cardiac disease. Methods We conducted a single-center prospective cross-sectional study between November 2021 and August 2022 on inpatients of the Department of Endocrinology, Nanjing Drum Tower Hospital. We included 150 patients aged 18–70 years with no signs, symptoms, or history of clinical cardiac disease. Patients were evaluated with speckle tracking echocardiography and dual energy X-ray absorptiometry. The cutoff values for subclinical systolic dysfunction were set at a global longitudinal strain (GLS) < 18%. Results After adjusting for sex and age, patients with GLS < 18% had a higher mean (± standard deviation) fat mass index (8.06 ± 2.39 vs. 7.10 ± 2.09 kg/m 2 , p = 0.02), higher mean trunk fat mass (14.9 ± 4.9 vs. 12.8 ± 4.3 kg, p = 0.01), and higher android fat mass (2.57 ± 1.02 vs. 2.18 ± 0.86 kg, p = 0.02) than those in the GLS ≥ 18%. Partial correlation analysis showed that the fat mass index, truck fat mass, and android fat mass were negatively correlated with GLS after adjusting for sex and age (all p < 0.05). Adjusted for traditional cardiovascular metabolic factors, fat mass index (odds ratio [OR] 1.27, 95% confidence interval [CI] 1.05–1.55, p = 0.02), trunk fat mass (OR 1.13, 95% CI 1.03–1.24, p = 0.01), and android fat mass (OR 1.77, 95% CI 1.16–2.82, p = 0.01) were independent risk factors for GLS < 18%. Conclusion Among patients with type 2 diabetes mellitus without established clinical cardiac disease, fat mass, especially android fat mass, was associated with subclinical systolic dysfunction independently of age and sex. Supplementary Information The online version contains supplementary material available at 10.1007/s13300-023-01411-7.

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Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases

Cited by 12 publications

References 166 publications

Case Series of Mild Myocarditis: The Role of Speckle Tracking Echocardiography in Detecting a Patchy Disease

Case Series of Mild Myocarditis: The Role of Speckle Tracking Echocardiography in Detecting a Patchy Disease

Longitudinal Cardiac Evaluation of Children with Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 by Conventional and Speckle-Tracking Echocardiography

Fat Mass is Associated with Subclinical Left Ventricular Systolic Dysfunction in Patients with Type 2 Diabetes Mellitus Without Established Cardiovascular Diseases

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