Advanced formulations and nanotechnology-based approaches for pulmonary delivery of sildenafil: A scoping review

Lazo, Raul Edison Luna; Mengarda, Mariana; Almeida, Susana Leão; Caldonazo, Aline; Espinoza, Joel Toribio; Murakami, Fábio S.

doi:10.1016/j.jconrel.2022.08.021

Cited by 11 publications

(7 citation statements)

References 75 publications

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“…It was reported that pulmonary delivery of 13% w/v Poloxamer-407 solutions to the deep lungs did not induce any inflammation in the lungs; however, it changed the permeability of the alveolo-capillary barrier, but this alteration was reversible over time [87]. The more diluted Poloxamer-based NE demonstrated higher biocompatibility than the more concentrated formulation, as it was reported that pulmonary delivery of low doses of various Poloxamers to the airways induces no signs of acute or chronic lung toxicity; however, high doses of Poloxamer-407 are pro-inflammatory and should be avoided in pulmonary application [88]. On the other hand, Cremophor EL was reported to induce pulmonary toxicity, as demonstrated by increased levels of LDH, total proteins, and neutrophils in the BAL fluid following intratracheal delivery [89].…”

Section: Histopathological Examinationmentioning

confidence: 99%

Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization

2022

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Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension (PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted delivery to the lungs through nebulization was proposed as an alternative approach. This poorly soluble drug was previously dissolved in nanoemulsions (NEs). However, the formulations could not resist aqueous dilution, which precluded its dilution with saline for nebulization. Thus, the current study aimed to modify the previous systems into dilutable TD-NEs and assess their suitability for a pulmonary application. In this regard, screening of various excipients was conducted to optimize the former systems; different formulations were selected and characterized in terms of physicochemical properties, nebulization performance, stability following sterilization, and biocompatibility. Results showed that the optimal system comprised of Capmul-MCM-EP:Labrafac-lipophile (1:1) (w/w) as oil, Labrasol:Poloxamer-407 (2:1) (w/w) as surfactant mixture (Smix) and water. The optimum formulation P2TD resisted aqueous dilution, exhibited reasonable drug loading (2.45 mg/mL) and globule size (25.04 nm), acceptable pH and viscosity for pulmonary administration, and could be aerosolized using a jet nebulizer. Moreover, P2TD demonstrated stability following sterilization and a favorable safety profile confirmed by both in-vitro and in-vivo toxicity studies. These favorable findings make P2TD promising for the treatment of pediatric PAH.

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Section: Histopathological Examinationmentioning

confidence: 99%

Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization

2022

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“…Thus, PDNs represent next-generation PDDSs and attracted tremendous attention from researchers worldwide. To date, numerous reviews have been published, summarizing the development of PDNs, which focused on diseases, [17][18][19] nanomaterials, [20][21][22] APIs 18,23 and physiologic barriers. 1 However, despite their promising role in the treatment and management of lung diseases, PDNs have several shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Wang,

Zhong,

Huang

et al. 2024

Nanoscale

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“…[28] To overcome these challenges, the development of intelligent inhalable drug delivery systems is extremely urgent. [29] Herein, we developed a brand-new non-pore dependent drug delivery system that completely differed from traditional porous drug delivery system. For this particle GSC system, the carrier preparation and drug encapsulation were carried out simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Non‐Pore Dependent and MMP‐9 Responsive Gelatin/Silk Fibroin Composite Microparticles as Universal Delivery Platform for Inhaled Treatment of Lung Cancer

Gou,

Wang,

Zou

et al. 2023

Advanced Materials

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Developing a drug delivery platform that possesses universal drug loading capacity to meet various requirements of cancer treatment is a challenging yet interesting task. Herein, a self‐assembled gelatin/silk fibroin composite particle (GSC) based drug delivery system is developed via microphase separation followed by desolvation process. Thanks to its pre‐assembled microphase stage, this GSC system is suitable for varying types of drugs. The desolvation process fix drugs inside GSC rapidly and densify the GSC structure, thereby achieving efficient drug loading and providing comprehensive protection for loaded drugs. Actually, the size of this brand‐new non‐pore dependent drug delivery system can be easily adjusted from 100 nm to 20 μm to fit different scenarios. We select GSC with 3 μm diameter as the universal inhaled drug delivery platform, which shows an excellent transmucosal penetration and lung retention ability. Additionally, the MMP‐9 sensitive degradation property of GSC enhances the targeted efficiency of drugs and reduces side effects. Intestinally, GSC can self‐amplify the regulation of innate immunity to reverse the cancerous microenvironment into an anti‐tumor niche, significantly improving the therapeutic effect of drugs. Our study of GSC universal drug platform provides a new direction to develop the next‐generation of drug delivery system for lung cancer.This article is protected by copyright. All rights reserved

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Advanced formulations and nanotechnology-based approaches for pulmonary delivery of sildenafil: A scoping review

Cited by 11 publications

References 75 publications

Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization

Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization

Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives

Non‐Pore Dependent and MMP‐9 Responsive Gelatin/Silk Fibroin Composite Microparticles as Universal Delivery Platform for Inhaled Treatment of Lung Cancer

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