An accurate evaluation of the non-linear behavior of masonry structural elements in existing buildings still represents a complex issue that rigorously requires non-linear finite element strategies difficult to apply to real large structures. Nevertheless, for the static and seismic assessment of existing structures, involving the contribution of masonry materials, engineers need reliable and efficient numerical tools, whose complexity and computational demand should be suitable for practical purposes. For these reasons, the formulation and the validation of simplified numerical strategies represent a very important issue in masonry computational research. In this paper, an innovative macroelement approach, developed by the authors in the last decade, is presented. The proposed macroelement formulation is based on different, plane and spatial, macroelements for the simulation of both the in-plane and out-of-plane behavior of masonry structures also in presence of masonry elements with curved geometry. The mechanical response of the adopted macroelement is governed by non-linear zero-thickness interfaces, whose calibration follows a straightforward fiber discretization, and the non-linear internal shear deformability is ruled by equivalence with a corresponding geometrically consistent homogenized medium. The approach can be considered as "parsimonious" since the kinematics of the adopted elements is controlled by very few degrees of freedom, if compared to a corresponding discretization performed by using non-linear finite element method strategies. This innovative discrete element strategy has been implemented in two user-oriented software codes 3DMacro (Caliò et al., 2012b) and HiStrA (Historical Structures Analysis) , which simplify the modeling of buildings and historical structures by means of several wizard generation tools and input/output facilities. The proposed approach, that represents a powerful tool for the structural assessment of structures in which the masonry plays a key role, is here validated against experimental results involving typical masonry monumental substructural elements and numerical results involving real-scale structures.