Advanced function, design and application of skin substitutes for skin regeneration

Zhang, Miao; Xing, Jiyao; Zhong, Yingjie; Zhang, Tingting; Liu, Xinlin; Xing, Dongming

doi:10.1016/j.mtbio.2023.100918

Cited by 9 publications

(3 citation statements)

References 150 publications

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“…In these situations, skin substitutes represent both a physical barrier against germs and a proper environment for wound healing. They mimic the structure and function of normal skin, promoting tissue healing and minimizing scarring, playing a crucial role in treating burns and chronic wounds [ 75 , 76 , 77 , 78 , 79 ].…”

Section: Overview Of Reconstructive Paradigmsmentioning

confidence: 99%

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Grosu-Bularda,

Hodea,

Cretu

et al. 2024

JCM

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The field of plastic surgery is continuously evolving, with faster-emerging technologies and therapeutic approaches, leading to the necessity of establishing novel protocols and solving models. Surgical decision-making in reconstructive surgery is significantly impacted by various factors, including the etiopathology of the defect, the need to restore form and function, the patient’s characteristics, compliance and expectations, and the surgeon’s expertise. A broad surgical armamentarium is currently available, comprising well-established surgical procedures, as well as emerging techniques and technologies. Reconstructive surgery paradigms guide therapeutic strategies in order to reduce morbidity, mortality and risks while maximizing safety, patient satisfaction and properly restoring form and function. The paradigms provide researchers with formulation and solving models for each unique problem, assembling complex entities composed of theoretical, practical, methodological and instrumental elements.

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Section: Overview Of Reconstructive Paradigmsmentioning

confidence: 99%

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Grosu-Bularda,

Hodea,

Cretu

et al. 2024

JCM

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show abstract

“…been developed, ranging from dressings that ensure the release of drugs controlled in time and space, three-dimensional printed biomaterials, to advanced skin substitutes that allow the replacement and regeneration of entire tissue layers [33]. Trends prevailing in the biological skin substitutes market predict that it will reach USD 321 million by 2023 and lead to the development of more sophisticated solutions [34].…”

Section: Wound Healing Complications-clinical Need For Advanced Productsmentioning

confidence: 99%

“…Therefore, research teams from all over the world are looking for more effective solutions and treatment methods. With the development of tissue engineering and regenerative medicine, many solutions personalized to specific patients have been developed, ranging from dressings that ensure the release of drugs controlled in time and space, three-dimensional printed biomaterials, to advanced skin substitutes that allow the replacement and regeneration of entire tissue layers [33]. Trends prevailing in the biological skin substitutes market predict that it will reach USD 321 million by 2023 and lead to the development of more sophisticated solutions [34].…”

Section: Wound Healing Complications-clinical Need For Advanced Productsmentioning

confidence: 99%

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Kondej,

Zawrzykraj,

Czerwiec

et al. 2024

IJMS

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Non-healing wounds and skin losses constitute significant challenges for modern medicine and pharmacology. Conventional methods of wound treatment are effective in basic healthcare; however, they are insufficient in managing chronic wound and large skin defects, so novel, alternative methods of therapy are sought. Among the potentially innovative procedures, the use of skin substitutes may be a promising therapeutic method. Skin substitutes are a heterogeneous group of materials that are used to heal and close wounds and temporarily or permanently fulfill the functions of the skin. Classification can be based on the structure or type (biological and synthetic). Simple constructs (class I) have been widely researched over the years, and can be used in burns and ulcers. More complex substitutes (class II and III) are still studied, but these may be utilized in patients with deep skin defects. In addition, 3D bioprinting is a rapidly developing method used to create advanced skin constructs and their appendages. The aforementioned therapies represent an opportunity for treating patients with diabetic foot ulcers or deep skin burns. Despite these significant developments, further clinical trials are needed to allow the use skin substitutes in the personalized treatment of chronic wounds.

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Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Han,

Choi,

Kang

2024

Adv Healthcare Materials

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Transdermal healthcare systems have gained significant attention for their painless and convenient drug administration, as well as their ability to detect biomarkers promptly. However, the skin barrier limits the candidates of biomolecules that can be transported, and reliance on simple diffusion poses a bottleneck for personalized diagnosis and treatment. Consequently, recent advancements in transdermal transport technologies have evolved toward active methods based on external energy sources. Multiple combinations of these technologies have also shown promise for increasing therapeutic effectiveness and diagnostic accuracy as delivery efficiency is maximized. Furthermore, wearable healthcare platforms are being developed in diverse aspects for patient convenience, safety, and on‐demand treatment. Herein, a comprehensive overview of active transdermal delivery technologies is provided, highlighting the combination‐based diagnostics, therapeutics, and theragnostics, along with the latest trends in platform advancements. This offers insights into the potential applications of next‐generation wearable transdermal medical devices for personalized autonomous healthcare.

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Advanced function, design and application of skin substitutes for skin regeneration

Cited by 9 publications

References 150 publications

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Reconstructive Paradigms: A Problem-Solving Approach in Complex Tissue Defects

Bioengineering Skin Substitutes for Wound Management—Perspectives and Challenges

Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

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