Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis

El-Saeed, Gamila S. M.; Fadel, Fatina; Elshamaa, Manal F.; Galal, Rasha; Elghoroury, Eman A.; Nasr, Soha A.; Thabet, Eman H.; Abdelrahman, Safaa M.

doi:10.3109/0886022x.2015.1077317

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…We also found a positive correlation between the AGEs level and sRAGE concentration in the AAA and HD patients, as well as in the CKD group. Our results are consistent with the observations made by El-Saeed et al, who demonstrated a positive correlation between the parameters mentioned above in children undergoing hemodialysis [40]. In general, the positive interrelationship between AGEs levels rather than the inverse relationship with sRAGE in humans, was observed [40,41].…”

Section: Discussionsupporting

confidence: 94%

“…Our results are consistent with the observations made by El-Saeed et al, who demonstrated a positive correlation between the parameters mentioned above in children undergoing hemodialysis [40]. In general, the positive interrelationship between AGEs levels rather than the inverse relationship with sRAGE in humans, was observed [40,41]. On the basis of the relationship mentioned above, we may conclude that AGEs stimulate the generation of sRAGE.…”

Section: Discussionsupporting

confidence: 93%

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Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid

Gryszczyńska

Budzyń

Formanowicz

et al. 2020

JCM

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Our study aimed to identify the relationship between advanced glycation end products (AGEs), soluble receptor for advanced glycation end products (sRAGE), the AGEs/sRAGE, and uric acid (UA) levels in selected atherosclerosis diseases, i.e., abdominal aortic aneurysms (AAA), aortoiliac occlusive disease (AIOD), and chronic kidney disease (CKD), resulting from apparent differences in oxidative stress intensity. Furthermore, we suggest that increased AGEs levels may stimulate an antioxidant defense system reflected by the UA level. The studied group size consisted of 70 AAA patients, 20 AIOD patients, 50 patients in the pre-dialyzed group (PRE), and 35 patients in the hemodialyzed group (HD). The enzyme-linked immunosorbent assay was used to measure AGEs and sRAGE levels. We found a significantly higher concentration of AGEs in CKD patients as compared to AAA and AIOD patients. Furthermore, the sRAGE level was higher in the CKD patients in comparison to AIOD and AAA patients. UA level was significantly higher in the PRE group compared to AAA patients. In conclusion, the diseases included in this study differ in the anti- and prooxidant defense system, which is reflected in the relations between the AGEs, the sRAGE, the AGEs/sRAGE ratio, as well as the UA levels.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid

Gryszczyńska

Budzyń

Formanowicz

et al. 2020

JCM

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“…Longstanding hyperglycemia in type 2 diabetes is a major cause of corneal nerve loss and peripheral nerve injury, resulting from advanced glycation end products, disruptions of axonal function, uncontrolled oxidative stress and reactive oxygen species, and abnormal hemodynamic regulatory pathways [ 25 ]. Concurrent chronic kidney disease in type 2 diabetes worsens these abnormalities [ 26 , 27 ], facilitating a more severe corneal nerve loss. Furthermore, chronic kidney disease is closely associated with hyperkalemia, which may mediate nerve dysfunction in chronic kidney disease by altering nerve ion channel function [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic Kidney Disease Has No Impact on Tear Film Substance P Concentration in Type 2 Diabetes

Asiedu,

Alotaibi,

Krishnan

et al. 2023

Biomedicines

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Purpose: The study aimed to ascertain the potential effects of chronic kidney disease (CKD) on substance P concentration in the tear film of people with type 2 diabetes. Methods: Participants were classified into two groups: type 2 diabetes with concurrent chronic kidney disease (T2DM–CKD (n = 25)) and type 2 diabetes without chronic kidney disease (T2DM–no CKD (n = 25)). Ocular surface discomfort assessment, flush tear collection, in-vivo corneal confocal microscopy, and peripheral neuropathy assessment were conducted. Enzyme-linked immunosorbent assays were utilized to ascertain the levels of tear film substance P in collected flush tears. Correlation analysis, hierarchical multiple linear regression analysis, and t-tests or Mann–Whitney U tests were used in the analysis of data for two-group comparisons. Results: There was no substantial difference between the T2DM–CKD and T2DM–no CKD groups for tear film substance P concentration (4.4 (0.2–50.4) and 5.9 (0.2–47.2) ng/mL, respectively; p = 0.54). No difference was observed in tear film substance P concentration between the low-severity peripheral neuropathy and high-severity peripheral neuropathy groups (4.4 (0.2–50.4) and 3.3 (0.3–40.7) ng/mL, respectively; p = 0.80). Corneal nerve fiber length (9.8 ± 4.6 and 12.4 ± 3.8 mm/mm2, respectively; p = 0.04) and corneal nerve fiber density (14.7 ± 8.5 and 21.1 ± 7.0 no/mm2, respectively; p < 0.01) were reduced significantly in the T2DM–CKD group compared to the T2DM–no CKD group. There were significant differences in corneal nerve fiber density (21.0 ± 8.1 and 15.8 ± 7.7 no/mm2, respectively; p = 0.04) and corneal nerve fiber length (12.9 ± 4.2 and 9.7 ± 3.8 mm/mm2, respectively; p = 0.03) between the low- and high-severity peripheral neuropathy groups. Conclusion: In conclusion, no significant difference in tear film substance P concentration was observed between type 2 diabetes with and without CKD. Corneal nerve loss, however, was more significant in type 2 diabetes with chronic kidney disease compared to type 2 diabetes alone, indicating that corneal nerve morphological measures could serve greater utility as a tool to detect neuropathy and nephropathy-related corneal nerve changes.

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“…Moreover, the categorization of healthy volunteers into quartiles according to AGEs level revealed their effect on sRAGE concentration. The literature data show that serum levels of AGEs correlate positively rather than inversely with sRAGE [30,31]. Nevertheless, these correlations were elevated in pathological conditions, not in case of healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Association between Advanced Glycation End Products, Soluble RAGE Receptor, and Endothelium Dysfunction, Evaluated by Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Mild and Resistant Hypertension

Gryszczyńska

Budzyń

Begier-Krasińska

et al. 2019

IJMS

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The aim of the present study was to evaluate advanced glycation end products (AGEs) and soluble form of receptor RAGE (sRAGE) concentrations as well as the AGEs/sRAGE ratio in mild (MH) and resistant (RH) hypertensive patients in comparison with normotensive individuals. We also evaluated the association between AGEs, sRAGE as well as AGEs/sRAGE ratio and circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs). The MH group consisted of 30 patients, whereas 30 patients were classified for the RH group. The control group (C) included 25 normotensive volunteers. AGEs and sRAGE were measured using enzyme-linked-immunosorbent assay (ELISA). The multicolor flow cytometry was used for analysis of CECs and CEPCs. Significantly higher levels of AGEs in RH cohort were observed as compared to C cohort. Furthermore, significantly lower sRAGE levels as well as a higher AGEs/sRAGE ratio were observed between MH and RH cohorts. Significant correlations were found in the MH cohort for sRAGE and CECs, and CEPCs. The elevation of AGEs levels suggests that oxidative modification of proteins occurs in hypertension pathogenesis. The decrease in sRAGE levels and elevation of the AGEs/sRAGE ratio in MH and RH groups may suggest that hypertensive patients are less protected against the side effects of AGEs as a consequence of an insufficient competitive role of sRAGE against the AGEs-RAGE axis. Finally, it may be concluded that the level of AGEs may be an independent predictor of the condition and function of the endothelium. Furthermore, sRAGE may be classified as a potential biomarker of inflammation and endothelium dysfunction.

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Advanced glycation end products and soluble receptor as markers of oxidative stress in children on hemodialysis

Cited by 10 publications

References 42 publications

Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid

Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid

Chronic Kidney Disease Has No Impact on Tear Film Substance P Concentration in Type 2 Diabetes

Association between Advanced Glycation End Products, Soluble RAGE Receptor, and Endothelium Dysfunction, Evaluated by Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Mild and Resistant Hypertension

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