Advanced glycation end products and schizophrenia: A systematic review

Kouidrat, Youssef; Amad, Ali; Arai, Makoto; Miyashita, Mitsuhiro; Lalau, Jean–Daniel; Loas, Gwenolé; Itokawa, Masanari

doi:10.1016/j.jpsychires.2015.04.023

Cited by 45 publications

(34 citation statements)

References 64 publications

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“…Indeed, skin AGE levels were significantly elevated in patients with severe schizophrenia (Kouidrat et al, 2015). Furthermore, increased skin AGEs levels showed relation with antipsychotics dose and its accumulative exposure periods in patients with a recent onset of psychosis (Hagen et al, 2017), as we also showed in serum study (Sannohe et al, 2017).…”

Section: Discussionsupporting

confidence: 76%

“…Both factors, namely, mild disease symptoms and low dosing of antipsychotics, may affect the levels of peripheral carbonyl stress markers (Arai et al, ; Katsuta et al, ; Kouidrat et al, ; Miyashita et al, ; Takeda et al, ). Indeed, skin AGE levels were significantly elevated in patients with severe schizophrenia (Kouidrat et al, ). Furthermore, increased skin AGEs levels showed relation with antipsychotics dose and its accumulative exposure periods in patients with a recent onset of psychosis (Hagen et al, ), as we also showed in serum study (Sannohe et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia

Tani

Ohnuma

Hirose

et al. 2019

Int J Methods Psych Res

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Objectives Photosensitivity to ultraviolet A (UVA) radiation from sunlight is an important side effect of treatment with antipsychotic agents. However, the pathophysiology of drug‐induced photosensitivity remains unclear. Recent studies demonstrated the accumulation of advanced glycation end products (AGEs), annotated as carbonyl stress, to be associated with the pathophysiology of schizophrenia. In this study, we investigated the relationship among skin AGE levels, minimal response dose (MRD) with UVA for photosensitivity, and the daily dose of antipsychotic agents in patients with schizophrenia and healthy controls. Methods We enrolled 14 patients with schizophrenia and 14 healthy controls. Measurement of skin AGE levels was conducted with AGE scanner, a fluorometric method for assaying skin AGE levels. Measurement of MRD was conducted with UV irradiation device. Results Skin AGE levels and MRD at 24, 48, and 72 hr in patients with schizophrenia showed a higher tendency for photosensitivity than in the controls, but the difference was statistically insignificant. Multiple linear regression analysis using skin AGE levels failed to show any influence of independent variables. MRD did not affect skin AGE levels. Conclusions Photosensitivity to UVA in patients with schizophrenia receiving treatment with antipsychotic agents might not be affected by skin AGE levels.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia

Tani

Ohnuma

Hirose

et al. 2019

Int J Methods Psych Res

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“…AGEs appear to not only accelerate aging and aggravate diabetes complications, but may also be involved in the development of many other health conditions [163][164][165][166][167][168]. Therefore, control of AGE accumulation should be an important component of health management.…”

Section: Resultsmentioning

confidence: 99%

Iridoids are natural glycation inhibitors

West¹,

Deng²,

Uwaya³

et al. 2016

Glycoconj J

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Glycation of amino acid residues in proteins leads to the eventual formation of advanced glycation end products (AGEs). AGE formation significantly influences human health and the aging process. AGE accumulation rates may be slowed by modifications to lifestyle or by pharmacological strategies. But the use of therapeutic drugs is not an appropriate means of controlling AGEs within the general population. However, phytochemical constituents in plant-based foods exhibit anti-glycation activities and may be more appropriate for general consumption. Among these phytochemicals are iridoids. The anti-AGE potential of iridoids has been demonstrated in vitro and in vivo, while also revealing possible mechanisms of action. Inclusion of iridoid food sources in the diet may be a useful component of strategies intended to mitigate AGE accumulation within the body.

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“…Studies have suggested that the accumulation of AGEs compromise tissue function, increase the susceptibility to injury and reduce healing capacity. In addition, AGE cross-links are thought to contribute to a number of human pathologies, including neurological disorders [12], diabetes and cardiovascular disease [13], and rheumatoid arthritis [14].…”

Section: Introductionmentioning

confidence: 99%

Bonded Force Constant Derivation of Lysine-Arginine Cross-linked Advanced Glycation End-Products

Nash¹,

Leeuw²,

Birch³

2018

Preprint

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<div> <div> <div> <p>The computational study of advanced glycation end-product cross- links remains largely unexplored given the limited availability of bonded force constants and equilibrium values for molecular dynamics force fields. In this article, we present the bonded force constants, atomic partial charges and equilibrium values of the arginine-lysine cross-links DOGDIC, GODIC and MODIC. The Hessian was derived from a series of <i>ab initio</i> quantum mechanical electronic structure calculations and from which a complete set of force constant and equilibrium values were generated using our publicly available software, ForceGen. Short <i>in vacuo</i> molecular dynamics simulations were performed to validate their implementation against quantum mechanical frequency calculations. </p> </div> </div> </div>

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Advanced glycation end products and schizophrenia: A systematic review

Cited by 45 publications

References 64 publications

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia

Iridoids are natural glycation inhibitors

Bonded Force Constant Derivation of Lysine-Arginine Cross-linked Advanced Glycation End-Products

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