Advanced glycation end products and their receptors did not show any association with body mass parameters in metabolically healthy adolescents

Garay‐Sevilla, Ma. Eugenia; Torres‐Graciano, Sofía; Villegas‐Rodríguez, Ma. Etzabel; Rivera-Cisneros, Antonio Eugenio; Wróbel, Katarzyna; Uribarri, Jaime

doi:10.1111/apa.14426

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…These results agree with another study that demonstrates that obese AGEs are significantly higher than non-obese (Antoniotti, et al [39] ). While disagreeing with other studies that stated that There was no correlation between obesity and circulating AGEs (Garay-Sevilla, et al [40] ). The effect of AGEs is classified as receptor-dependent via binding to the AGE receptor (RAGE) or receptorindependent (such as cross-links with extracellular matrix) (Haddad, et al [41] ).…”

Section: Discussioncontrasting

confidence: 60%

Glycotoxins Relationship with Body Mass Index (BMI)

Yousif

Jwad

Al-Hilli

2020

IJEIR

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Glycotoxins termed as advanced glycation endproducts (AGEs) are made endogenously and exogenously. Maillard reaction is a chemical non-enzymatic process, between sugars and a free amino acid group of nucleic acids, proteins, and lipids which happens exogenously when handled with high temperature for a prolonged period and in a dry environment, resulting in glycotoxins (AGEs) formations. This reaction is responsible for the taste, color, and smell of food. Glycotoxins derived from food are absorbed in the intestine and store in cells and tissues. Also, glycotoxins are derived exogenously from smoking. While endogenous glycotoxins are generated by normal body physiology. Obesity and insulin resistance may induce glycotoxins (AGEs) accumulation. The objective of this study was to evaluate the relationship between glycotoxins (AGEs) and obesity. 66 infertile females who were undergoing intracytoplasmic sperm injection ICSI. These females were classified into three groups according to their body mass index. On the day of ova pick up the collect serum and follicular fluid for subsequent measurement of glycotoxins (AGEs) by ELISA kits. there was a significant difference in the concentration of glycotoxins in follicular fluid and serum between the three ICSI groups of patients. As well as there was a significant difference in the concentration of glycotoxins (AGEs) in follicular fluid and serum in the same ICSI groups of patients. there is a significant positive relation between glycotoxins (AGEs) and increase BMI.

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Section: Discussioncontrasting

confidence: 60%

Glycotoxins Relationship with Body Mass Index (BMI)

Yousif

Jwad

Al-Hilli

2020

IJEIR

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“…Other studies confirmed that obesity is associated with lower levels of sRAGE in pre-pubertal cohorts of children (23, 24) and reported that sRAGE was independently associated with liver steatosis (23) and carotid intima-media thickness (24). However, recently, other authors did not find any significant association between markers of obesity and AGEs or sRAGE (25).…”

Section: Discussionmentioning

confidence: 95%

Could AGE/RAGE-Related Oxidative Homeostasis Dysregulation Enhance Susceptibility to Pathogenesis of Cardio-Metabolic Complications in Childhood Obesity?

et al. 2019

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Background: Advanced glycation end-products (AGEs) and their cell receptor (RAGE) are involved in the pathophysiology of cardio-metabolic diseases. Interaction of AGEs with RAGE results in increased generation of oxygen radicals and pro-inflammatory cytokines. Circulating soluble RAGE (sRAGE) interacts with AGEs in order to counterbalance the negative effects of AGEs-RAGE interaction. Objectives: To define factors influencing AGEs, sRAGE, AGEs/sRAGE-ratio, and advanced oxidation-protein products (AOPPs) levels and to investigate changes in oxidative balance among overweight/obese children. Materials and methods: Cross-sectional, one Center, case-control study included 41 overweight and obese children aged between 5 and 16 years and 36 lean matched controls. Inclusion criteria were: BMI ≥ 1 SD; term birth; no genetic or endocrine causes of obesity; no associated chronic diseases neither chronic therapies. All patients underwent clinical and biochemical investigations (lipid and glucose profiles, liver, renal and thyroid function tests, uric acid, C-reactive protein (CRP), AGEs, sRAGE, and AOPPs serum concentrations). Significance was established at 0.050. Results: AOPPs, AGEs/sRAGE-ratio, HOMA-IR, triglycerides, triglycerides/HDL-ratio, total cholesterol (TC)/HDL-ratio, atherogenic-index of plasma (AIP), uric acid, CRP were significantly higher, whereas sRAGE and HDL were significantly lower in overweight/obese children than controls. sRAGE was significantly negatively correlated with BMI SD, TC/HDL-ratio, CRP, AOPPs, and positively with HDL. AGE/sRAGE-ratio and AOPPs were significantly positively correlated with BMI SD, TC/HDL-ratio, AIP, CRP, and negatively with HDL. BMI SD was independently associated with AGEs/sRAGE-ratio ( B = 0.06; p = 0.008), AOPPs ( B = 0.13; p = 0.02), and sRAGE ( B = −73.18; p = 0.000). Conclusions: We demonstrated, for the first time in a pediatric cohort, a significant higher value of AGEs/sRAGE-ratio among overweight/obese children, expression of a relative shift to oxidant from anti-oxidant factors, suggesting an AGE/RAGE-related oxidative homeostasis dysregulation that could enhance susceptibility to oxidative/inflammatory tissues damage. Severity of overweight, influencing the increase of oxidative stress in human organism and even in children, may contribute to the pathogenesis of long-term cardiovascular and metabolic alterations.

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“…Serum AGEs and sRAGE levels were not related to vascular complications in patients with prediabetes nor impaired glucose metabolism in patients with type 2 diabetes [78,79]. Although in higher levels, CML and sRAGE were also not associated with obesity or inflammation in unhealthy obese adolescents [80]. It is likely that total AGEs levels are not directly associated with insulin resistance or vascular complications, but modification of specific proteins or accumulation in tissue may by better markers of such complications.…”

Section: Evidence In Human Studiesmentioning

confidence: 91%

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

Matafome

2020

Diabetology

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The term glycotoxins includes the group of advanced glycation end-products (AGEs) and their precursors, most of them highly reactive intermediary compounds, such as methylglyoxal (MG). Glycotoxins were initially thought to participate in the development of diabetic complications because of their increased formation from glucose. However, they also form and accumulate in tissues since the early stages of disease, such as metabolically unhealthy obesity and prediabetes. Such accumulation has been suggested to result from dysregulated activity of detoxification systems, such as the glyoxalase system, as well as increased dietary consumption, namely from high-glucose and high-fructose foods processed at high temperatures. Although some studies may have used supraphysiological doses, in vitro systems and animal models have shown glycotoxin-induced insulin resistance. Moreover, dietary glycotoxin restriction was shown to improve insulin resistance in humans and glyoxalase (GLO)-1 upregulation improved insulin sensitivity and metabolic function. This review summarizes the current knowledge about glycotoxin involvement in the development of insulin resistance, the mechanisms involved and the usefulness of GLO-1 modulation, and a possible therapeutic strategy to improve insulin sensitivity.

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Advanced glycation end products and their receptors did not show any association with body mass parameters in metabolically healthy adolescents

Abstract: HOMA-IR and the TG/HDL-C index were associated with BMI and inflammation markers. CML and sRAGE were not associated with obesity or inflammation. These parameters were higher in unhealthy obese adolescents.

Cited by 11 publications

References 27 publications

Glycotoxins Relationship with Body Mass Index (BMI)

Glycotoxins Relationship with Body Mass Index (BMI)

Could AGE/RAGE-Related Oxidative Homeostasis Dysregulation Enhance Susceptibility to Pathogenesis of Cardio-Metabolic Complications in Childhood Obesity?

Another Player in the Field: Involvement of Glycotoxins and Glycosative Stress in Insulin Secretion and Resistance

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