Advanced glycation end products as a biomarker for incisional hernia

Harlaar, Joris Jan; Eker, Hasan Hüseyin; Vakalopoulos, Konstantinos A.; Cabezas, Manuel Castro; Ham, Arie C. van der; Vrijland, W. W.; Jeekel, J.; Lange, Johan F.

doi:10.1007/s10029-017-1610-2

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…A recent Dutch study found that advanced glycation end products (AGEs) might be used as a biomarker for incisional hernia. Measurements based on the use of a Skin Auto Fluorescence (SAF) reader revealed that AGEs were significantly higher in patients with incisional hernia than in the control group (88). AGEs are harmful compounds generated by non-specific glycation of proteins and lipids which are related to cardiovascular diseases, arteriosclerosis, and neurodegeneration (89).…”

Section: Discussionmentioning

confidence: 99%

Hernia and Cancer: The Points Where the Roads Intersect

Kulaçoğlu¹,

Köckerling

2019

Front. Surg.

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Introduction: This review aimed to present common points, intersections, and potential interactions or mutual effects for hernia and cancer. Besides direct relationships, indirect connections, and possible involvements were searched. Materials and Methods: A literature search of PubMed database was performed in July 2018 as well as a search of relevant journals and reference lists. The total number of screened articles was 1,422. Some articles were found in multiple different searches. A last PubMed search was performed during manuscript writing in December 2018 to update the knowledge. Eventually 427 articles with full text were evaluated, and 264 included, in this review. Results: There is no real evidence for a possible common etiology for abdominal wall hernias and any cancer type. The two different diseases had been found to have some common points in the studies on genes, integrins, and biomarkers, however, to date no meaningful relationship has been identified between these points. There is also some, albeit rather conflicting, evidence for inguinal hernia being a possible risk factor for testicular cancer. Neoadjuvant or adjuvant therapeutic modalities like chemotherapy and radiotherapy may cause postoperative herniation with their adverse effects on tissue repair. Certain specific substances like bevacizumab may cause more serious complications and interfere with hernia repair. There are only two articles in PubMed directly related to the topic of “hernia and cancer.” In one of these the authors claimed that there was no association between cancer development and hernia repair with mesh. The other article reported two cases of squamous-cell carcinoma developed secondary to longstanding mesh infections. Conclusion: As expected, the relationship between abdominal wall hernias and cancer is weak. Hernia repair with mesh does not cause cancer, there is only one case report on cancer development following a longstanding prosthetic material infections. However, there are some intersection points between these two disease groups which are worthy of research in the future.

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Section: Discussionmentioning

confidence: 99%

Hernia and Cancer: The Points Where the Roads Intersect

Kulaçoğlu¹,

Köckerling

2019

Front. Surg.

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“…For each patient with SP, we assigned one who was never diagnosed with SP via propensity score matching. The matching variables were age; sex; index year; and comorbidities including hypertension (ICD-9-CM codes 401-405) [13,14], diabetes (ICD-9-CM codes 250) [15,16], hyperlipidemia (ICD-9-CM code 272) [17] and smoking related disease (ICD-9-CM codes 305.1, 430-438, 410-414, 493 and 496) [18].…”

Section: Study Populationmentioning

confidence: 99%

Risk of diaphragmatic hernia in patients with spontaneous pneumothorax

et al. 2022

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Background Few studies have implied the incidence of diaphragmatic hernia (DH) after spontaneous pneumothorax (SP) with unknown mechanisms. The current study aimed to identify whether there is an association between the DH and SP. Methods We selected 46,897 patients with SP (SP cohort) and 46,897 without SP (non-SP matched cohort) from the National Health Insurance Database. Patients were frequency matched according to age, sex, and index year. The incidence of DH and its association with SP were assessed after stratifying different characteristics and comorbidities. Statistical analysis including chi-square test, t-test, cox proportional hazard model, and Kaplan–Meier method were used. Results The results suggested there were significant associations between SP and DH, especially in the subgroup of patients with older age (aged 40–64 years: 2.61-fold in adjusted hazard ratio (aHR), 95% confidence interval (CI): 1.27–5.36; aged > 65 years: 1.97-fold in aHR, 95% CI 1.43–2.71), male sex (2.11-fold in aHR, 95% CI 1.56–2.85), hypertension (2.05-fold in aHR, 95% CI 1.30–3.23), diabetes mellitus (2.58-fold in aHR, 95% CI 1.37–4.86), and smoking-related disease (1.86-fold in aHR, 95% CI 1.28–2.71). The SP cohort has significantly correlated with DH within 5-year follow-up (< 2 years: 3.22-fold in aHR, 95% CI 2.10–4.94; 2–5 years: 1.70-fold in aHR, 95% CI 1.05–2.75). Conclusions The SP cohort had a higher incidence of DH than the non-SP matched cohort. A prospective study of indications based on the findings of the current research should be performed.

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“…Other experiments include development of stronger suture material (polyurethane), and mesh derived sutures (for better resistance against suture cut-through) for abdominal closure [67,68]. Recently biomarkers (proteins assays associated with wound healing, advanced glycation end products/ collagen cross links) have been shown to predict personal hernia risk prior to undergoing an operation; if validated, tests for these can be included in hernia prediction models [69,70].…”

Section: Safety Of Synthetic Mesh In Presence Of Infection and Strangulationmentioning

confidence: 99%

Prevention of Incisional Hernia: What is new?

Sharma¹

2018

GMR

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Incisional hernia (IH) is among the commonest post-operative complication after midline laparotomy. In spite of all technological advances its incidence remains 5-26%; prompting surgeons to think about IH prevention techniques. A scrutiny of factors associated with IH clearly shows that most of these are patient related and are beyond the Surgeon's control. However, there are a few Surgeon-related preventive measures which can help in bringing down the incidence of IH. These include efforts directed at reducing surgical site infection, preferred use of laparoscopy over conventional open surgery, preferred use of transverse incision, using current recommendations for midline laparotomy closure, incisional reinforcement in high risk groups by prophylactic mesh, special incisions/ techniques for prevention of IH in special circumstances, identification of high-risk cases and their centralized care, and increasing awareness of safety of synthetic mesh in presence of infection and strangulation. This brief review is based on relevant published literature in 'PubMed' and 'Google Scholar' since 2013. Now that it is possible to identify high risk patients for development of IH, high quality evidence is available for its prevention and the preventive measures do not require expansive resources; time has come to convert available knowledge to implementation.

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Advanced glycation end products as a biomarker for incisional hernia

Cited by 7 publications

References 24 publications

Hernia and Cancer: The Points Where the Roads Intersect

Hernia and Cancer: The Points Where the Roads Intersect

Risk of diaphragmatic hernia in patients with spontaneous pneumothorax

Prevention of Incisional Hernia: What is new?

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