Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation

Chen, Hanbei; Wu, Lifang; Li, Yakui; Meng, Jian; Lin, Ning; Yang, Dianqiang; Zhu, Yemin; Li, Xiaoyong; Li, Minle; Xu, Ye; Wu, Yuchen; Tong, Xuemei; Su, Qing

doi:10.1016/j.mce.2014.07.021

Cited by 47 publications

(46 citation statements)

References 39 publications

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“…High glucose levels also enhance resistance to 5-fluoruracil-induced apoptosis [63]. AGE-induced CRC cell proliferation requires carbohydrate response element-binding protein (ChREBP) [64], a key transcription factor also involved in DKD [65]. The polyol and hexosamine pathways, which increase glucose oxidation, are upregulated in diabetes target organ epithelial cells [54] and in colon cancer [66].…”

Section: Potential Molecular Mechanisms Of the Association Between Dmmentioning

confidence: 99%

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

et al. 2017

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Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and 57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be 27% higher in patients with type 2 DM than in non-diabetic controls. However, there are potential confounders, information from lower income countries is scarce, across the globe there is no correlation between DM prevalence and colorectal cancer incidence and the association has evolved over time, suggesting the impact of additional environmental factors. The clinical relevance of these associations depends on understanding the mechanism involved. Although evidence is limited, insulin use has been associated with increased and metformin with decreased incidence of colorectal cancer. In addition, colorectal cancer shares some cellular and molecular pathways with diabetes target organ damage, exemplified by diabetic kidney disease. These include epithelial cell injury, activation of inflammation and Wnt/β-catenin pathways and iron homeostasis defects, among others. Indeed, some drugs have undergone clinical trials for both cancer and diabetic kidney disease. Genome-wide association studies have identified diabetes-associated genes (e.g. TCF7L2) that may also contribute to colorectal cancer. We review the epidemiological evidence, potential pathophysiological mechanisms and therapeutic implications of the association between DM and colorectal cancer. Further studies should clarify the worldwide association between DM and colorectal cancer, strengthen the biological plausibility of a cause-and-effect relationship through characterization of the molecular pathways involved, search for specific molecular signatures of colorectal cancer under diabetic conditions, and eventually explore DM-specific strategies to prevent or treat colorectal cancer.

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Section: Potential Molecular Mechanisms Of the Association Between Dmmentioning

confidence: 99%

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

et al. 2017

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“…AGEs in general have been implicated in the development of diabetes (17, 18) and in ocular (19), renal (20), cardiovascular (21), and some neurodegenerative disorders (22), as well as in several cancers (23, 24). For their part, glycer-AGEs have been shown to be cytotoxic in vitro (25, 26) and findings from animal studies suggest involvement in the pathogenesis of insulin resistance and diabetes (27) as well as its complications (28).…”

Section: Introductionmentioning

confidence: 99%

The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Kong

Takeuchi

Hyogo

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background A large proportion of colorectal cancers (CRC) are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds known as glyceraldehyde-derived advanced glycation end-products (glycer-AGEs) which may promote CRC through their pro-inflammatory and pro-oxidative properties. The objective of this study nested within a prospective cohort was to explore the association of circulating glycer-AGEs with risk of CRC. Methods 1,055 CRC cases (colon n = 659; rectal n = 396) were matchced (1:1) to control subjects. Circulating glycer-AGEs were measured by a competitive enzyme-linked immunosorbent assay. Multivariable conditional logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for potential confounding factors including smoking, alcohol, physical activity, body mass index, and diabetes status. Results Elevated glycer-AGEs levels were not associated with CRC risk (highest vs. lowest quartile, 1.10; 95% CI, 0.82-1.49). Sub-group analyses showed possible divergence by anatomical sub-sites (OR for colon cancer = 0.83; 95% CI, 0.57-1.22; OR for rectal cancer = 1.90; 95% CI, 1.14-3.19; pheterogeneity = 0.14). Conclusions In this prospective study, circulating glycer-AGEs were not associated with risk of colon cancer, but showed a positive association with the risk of rectal cancer. Impact Further research is needed to clarify the role of toxic products of carbohydrate metabolism and energy excess in CRC development.

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“…The differences between the results of PFMA and PGMA are probably related to the higher hydrolysis rate and fructose release rate to the culture medium. Nutrients such as glucose, fructose and fatty acids are reported to stimulate both expression and activation of the key transcription factor, which is reported to increase cell proliferation . Therefore, neither the hydrogels nor their degradation products in culture medium are cytotoxic, making PFMA and PGMA hydrogels suitable materials for biomedical applications.…”

Section: Resultsmentioning

confidence: 99%

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

Perin

Fonseca

Felisberti

2019

J of Chemical Tech & Biotech

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BACKGROUND Readily available feedstock and biocompatibility make carbohydrate‐based hydrogels promising materials for biomedical applications. However, carbohydrate‐based crosslinkers are rather underexplored when compared with crosslinkers derived from fossil resources. In this study, novel fully bio‐based hydrogels derived from enzymatically produced d‐fructose and d‐glucose methacrylate monomers were synthesized with different amounts of d‐fructose dimethacrylate crosslinker. RESULTS The use of a carbohydrate‐based crosslinker endows hydrogels with high swelling coefficients, up to 2400%, and superior mechanical resistance (compressive modulus up to 9.5 kPa with a maximum stress up to 50 kPa) compared with conventional crosslinkers based on fossil resources. Hydrogels shape and crosslinking density influences hydrogel morphology, swelling behavior and mechanical resistance. Moreover, hydrogels presented cell viability, biodegradability and hydrolysis‐resistance over a wide range of pH. CONCLUSION The use of a highly hydrophilic crosslinker based on carbohydrate for hydrogels synthesis enables the use of high crosslinker concentration, which improves mechanical properties, however with minor loss of the water swelling capacity, compared with conventional fossil‐based crosslinkers. This is an important advantage over conventional crosslinkers based on fossil resources. Moreover, slab hydrogels hold higher stress under compression–decompression cycles, and present higher resistance to hydrolysis in basic medium due to the thicker pore walls than cylindrical ones. © 2019 Society of Chemical Industry

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Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation

Cited by 47 publications

References 39 publications

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications

The Association between Glyceraldehyde-Derived Advanced Glycation End-Products and Colorectal Cancer Risk

Macroporous hydrogels based on carbohydrates monomethacrylates and dimethacrylates: singular properties from carbohydrate‐based crosslinkers

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