Advanced Glycation End Products Inhibit Production and Activity of Matrix Metalloproteinase-2 in Human Umbilical Vein Endothelial Cells

Gao, Ling; Lee, Kang; Chen, Q; Chen, C; Xu, Baojun; Jiang, Sai

doi:10.1177/147323000703500517

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…23 In contrast, earlier study suggested that the stimulation of AGE receptors resulted in upregulation of inflammatory cytokines and MMPs, contributing to aneurysmal formation. 37,38 In support of this, a recent study found that serum concentrations of the AGE carboxymethyllysine were lower in patients with AAA. 39 Glycation of the aortic media inhibits MMP secretion (in contrast to glycation of atherosclerotic intima which stimulates MMP secretion 23,30 ).…”

Section: Biology Of the Wallmentioning

confidence: 82%

Diabetes and the Abdominal Aortic Aneurysm

Shantikumar

Ajjan

Porter

et al. 2010

European Journal of Vascular and Endovascular Surgery

142

121

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Section: Biology Of the Wallmentioning

confidence: 82%

Diabetes and the Abdominal Aortic Aneurysm

Shantikumar

Ajjan

Porter

et al. 2010

European Journal of Vascular and Endovascular Surgery

142

121

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“…Hence, a situation where post-translational modifications on collagen, e.g. glycation, that effectively inhibit proteolysis by MMPs, could ultimately result in decreased collagen degradation even if MMPs activity was increased 49 .…”

Section: Discussionmentioning

confidence: 99%

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

Magalhães

Pejchinovski

Markoska

et al. 2017

Sci Rep

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Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues. The urinary proteome was analysed by capillary electrophoresis coupled to mass spectrometry. CKD273 displayed a significant and positive correlation with the degree of fibrosis (Rho = 0.430, P = 0.0044), while the routinely used parameters (glomerular filtration rate, urine albumin-to-creatinine ratio and urine protein-to-creatinine ratio) did not (Rho = −0.222; −0.137; −0.070 and P = 0.16; 0.39; 0.66, respectively). We identified seven fibrosis-associated peptides displaying a significant and negative correlation with the degree of fibrosis. All peptides were collagen fragments, suggesting that these may be causally related to the observed accumulation of ECM in the kidneys. CKD273 and specific peptides are significantly associated with kidney fibrosis; such an association could not be detected by other biomarkers for CKD. These non-invasive fibrosis-related biomarkers can potentially be implemented in future trials.

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“…21,26 Furthermore, AGEs enable covalent cross-linking, which promotes the stiffening of the ECM, rendering it less prone to proteolysis, and decreasing the possibility of aneurysmal growth and rupture. 20,21,27,28 Additionally, patients with type 2 DM have 2-fold reduced levels and activity of MMP-2 and MMP-9, thus restricting the degradation and remodeling of aortic wall ECM proteins. 21,29 Moreover, EMMPRIN (membrane-bound protein inducing expression of several MMPs) levels in the arterial tissue are decreased in DM, indicating that reduced inducer protein levels may result in decreased MMP expression.…”

Section: Discussionmentioning

confidence: 99%

Negative Association of Diabetes With Thoracic Aortic Dissection and Aneurysm

Takagi

Umemoto

2016

Angiology

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We performed a meta-analysis to assess the association of diabetes mellitus (DM) with the presence of thoracic aortic dissection (TAD) and/or thoracic aortic aneurysm (TAA). MEDLINE and EMBASE were searched through December 2015 using PubMed and OVID. For each study, data regarding DM prevalence in both the TAD/TAA and control groups were used to generate unadjusted odds ratios (ORs) for DM and 95% confidence intervals (CIs). Alternatively, an unadjusted and/or adjusted OR was directly abstracted from each individual study. Eleven eligible studies enrolling a total of 47 827 participants were included. A primary pooled analysis of all the 11 studies demonstrated that TAD/TAA was associated with significantly lower DM prevalence than controls (OR, 0.43; 95% CI, 0.31-0.59; P < .00001). Separate pooled analyses of 6 TAD case studies and 4 TAA case studies demonstrated TAD (OR, 0.34; 95% CI, 0.19-0.61; P = .0003) and TAA (OR, 0.65; 95% CI, 0.45-0.94; P = .02) were associated with significantly lower DM prevalence than controls. In conclusion, DM may be negatively associated with the presence of TAD/TAA.

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Advanced Glycation End Products Inhibit Production and Activity of Matrix Metalloproteinase-2 in Human Umbilical Vein Endothelial Cells

Abstract: The aim of this study was to investigate the effects of advanced glycation end products

Cited by 9 publications

References 13 publications

Diabetes and the Abdominal Aortic Aneurysm

Diabetes and the Abdominal Aortic Aneurysm

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

Negative Association of Diabetes With Thoracic Aortic Dissection and Aneurysm

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