Advanced glycation end‐products (<scp>AGEs</scp>) and associations with cardio‐metabolic, lifestyle, and dietary factors in a general population: the <scp>NQplus</scp> study

Botros, Nadia; Sluik, Diewertje; Waateringe, Robert P. van; Vries, J.H.M. de; Geelen, Anouk; Feskens, Edith J. M.

doi:10.1002/dmrr.2892

Cited by 25 publications

(24 citation statements)

References 43 publications

(124 reference statements)

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“…SAF increases with age, the strongest risk factor for cardiovascular events in T1D [ 8 ]. SAF has recently been related to the components of the metabolic syndrome [ 34 ], especially low HDL-cholesterol and arterial hypertension [ 35 ], that increasingly mediate the effect of glucose control on cardiovascular risk in aging T1D [ 5 ]. The progression of SAF in our patients with T1D highly depends on their glomerular filtration rates [ 15 ], as expected because renal insufficiency reduces the clearance of AGEs.…”

Section: Discussionmentioning

confidence: 99%

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Blanc-Bisson

Vélayoudom-Céphise

Cougnard‐Grégoire

et al. 2018

Cardiovasc Diabetol

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BackgroundAdvanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searched for an association between SAF and major adverse cardiovascular events (MACE) incidence in subjects with Type 1 Diabetes (T1D) during a 7 year follow-up.MethodsDuring year 2009, 232 subjects with T1D were included. SAF measurement, clinical [age, sex, body mass index (BMI), comorbidities] and biological data (HbA1C, blood lipids, renal parameters) were recorded. MACE (myocardial infarction, stroke, lower extremity amputation or a revascularization procedure) were registered at visits in the center or by phone call to general practitioners until 2016.ResultsThe participants were mainly men (59.5%), 51.5 ± 16.7 years old, with BMI 25.0 ± 4.1 kg/m2, diabetes duration 21.5 ± 13.6 years, HbA1C 7.6 ± 1.1%. LDL cholesterol was 1.04 ± 0.29 g/L, estimated Glomerular Filtration Rates (CKD-EPI): 86.3 ± 26.6 ml/min/1.73 m2. Among these subjects, 25.1% were smokers, 45.3% had arterial hypertension, 15.9% had elevated AER (≥ 30 mg/24 h), and 9.9% subjects had a history of previous MACE. From 2009 to 2016, 22 patients had at least one new MACE: 6 myocardial infarctions, 1 lower limb amputation, 15 revascularization procedures. Their SAF was 2.63 ± 0.73 arbitrary units (AU) vs 2.08 ± 0.54 for other patients (p = 0.002). Using Cox-model, after adjustment for age (as the scale time), sex, diabetes duration, BMI, hypertension, smoking status, albumin excretion rates, statin treatment and a previous history of MACE, higher baseline levels of SAF were significantly associated with an increased risk of MACE during follow-up (HR = 4.13 [1.30–13.07]; p = 0.02 for 1 AU of SAF) and Kaplan–Meier curve follow-up showed significantly more frequent MACE in group with SAF upper the median (p = 0.001).ConclusionA high SAF predicts MACE in patients with T1D.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0718-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Blanc-Bisson

Vélayoudom-Céphise

Cougnard‐Grégoire

et al. 2018

Cardiovasc Diabetol

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“…We found positive correlations between SAF and age, both in psoriatic patients and healthy controls. Correlations between SAF and age were previously reported [ 31 , 32 ]. Although we did not find any significant difference in SAF between the whole group of patients with psoriasis and controls, we showed that individuals suffering from psoriasis, with elevated CRP levels and increased ESR, had significantly increased SAF as compared to controls.…”

Section: Discussionmentioning

confidence: 82%

Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis

Kopeć-Pyciarz

Makulska

Zwołińska

et al. 2018

Mediators of Inflammation

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Background Psoriasis is currently regarded as a chronic systemic inflammatory disease associated with increased cardiovascular risk. Advanced glycation end products (AGEs) contribute to the development of atherosclerosis. Objectives The aim of the study was the assessment of skin autofluorescence (SAF), as a measure of AGE accumulation, in individuals suffering from chronic plaque psoriasis without any comorbid conditions. Methods A study group consisted of 70 patients with chronic plaque psoriasis without any comorbid conditions and 59 healthy controls, matched by age and gender. AGE accumulation was assessed by SAF (AGE Reader, DiagnOptics BV) which is a validated and noninvasive technique. Relations between SAF and some clinical and laboratory data were assessed. Results SAF was positively correlated with age both in patients with psoriasis and controls (R = 0.722, p < 0.00001 and R = 0.613, p < 0.00001, respectively). There was significantly increased SAF in patients with psoriasis with elevated levels of C-reactive protein (CRP) and increased erythrocyte sedimentation rate (ESR) compared to controls (p < 0.00001; p < 0.00001, respectively, after adjustment to age). Increased SAF was found in psoriatic patients with prediabetes (HbA1c 5.7–6.4%) compared to controls (p < 0.0012, after adjustment to age). Conclusion Systemic inflammation (increased CRP level), prediabetes, and aging may influence enhanced AGE accumulation in patients with psoriasis without any comorbidities. SAF may be considered as a useful, noninvasive method to identify patients with psoriasis at increased cardiovascular risk.

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“…The interaction between AGE-RAGE, or RAGE-other ligands, on inflammatory cells stabilizes the receptor in the active state and amplifies inflammation by favoring the release of cytokines and chemokines, the production of reactive oxygen species and the activation of metalloproteases. Inflammation in turn is associated with induction of more AGEs, thus spreading the inflammatory response through this vicious circle formation [ 21 ].…”

Section: Advanced Glycation End Products (Ages)mentioning

confidence: 99%

“…Excessive AGEs accumulation in tissues has been documented in different disorders particularly in metabolic diseases such as diabetes and obesity and AGEs may have a relevant role in the tissue changes and clinical complications associated with these diseases [ 8 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ].…”

Section: Advanced Glycation End Products (Ages)mentioning

confidence: 99%

“…AGEs also modify LDLs and promote their uptake by macrophages with foam cell formation [ 51 , 52 ]. The main pathway linking AGEs to cardiovascular risk includes activation of the AGE-RAGE axis with release of oxygen species that induce endothelial cell activation, arterial inflammation, endothelial dysfunction, arterial stiffness, direct myocardial damage and chronic coronary and myocardial inflammation [ 5 , 21 , 40 ]. Serum levels of AGEs increased and correlated with the severity of cardiovascular disease in patients with type II diabetes mellitus and coronary heart disease [ 43 ].…”

Section: Age Diabetes Mellitus and Chronic Disordersmentioning

confidence: 99%

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Advanced Glycation End Products in the Pathogenesis of Psoriasis

Papagrigoraki

Maurelli

Giglio

et al. 2017

IJMS

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Advanced glycation end products (AGEs) are extremely oxidant and biologically reactive compounds, which form through oxidation of sugars, lipids and amino acids to create aldehydes that bind covalently to proteins. AGEs formation and accumulation in human tissues is a physiological process during ageing but it is enhanced in case of persistent hyperglycemia, hyperlipidemia and oxidative or carbonyl stress, which are common in patients with moderate to severe psoriasis. Exogenous AGEs may derive from foods, UV irradiation and cigarette smoking. AGEs elicit biological functions by activating membrane receptors expressed on epithelial and inflammatory cell surface. AGEs amplify inflammatory response by favoring the release of cytokines and chemokines, the production of reactive oxygen species and the activation of metalloproteases. AGEs levels are increased in the skin and blood of patients with severe psoriasis independently of associated metabolic disorders. Intensified glycation of proteins in psoriasis skin might have a role in fueling cutaneous inflammation. In addition, AGEs released from psoriatic skin may increase metabolic and cardiovascular risk in patients with severe disease.

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Advanced glycation end‐products (AGEs) and associations with cardio‐metabolic, lifestyle, and dietary factors in a general population: the NQplus study

Cited by 25 publications

References 43 publications

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study

Skin Autofluorescence, as a Measure of AGE Accumulation in Individuals Suffering from Chronic Plaque Psoriasis

Advanced Glycation End Products in the Pathogenesis of Psoriasis

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