Advanced imaging in surveillance of Barrett’s esophagus: Is the juice worth the squeeze?

Cerrone, Sara; Trindade, Arvind J.

doi:10.3748/wjg.v25.i25.3108

Cited by 7 publications

(7 citation statements)

References 31 publications

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“…Endoscopy can detect esophageal cancer, even those at an early stage [ 25 ]. Using a combination of high-definition white light, narrow band imaging, and both targeted and random biopsy, endoscopy can detect mucosal abnormalities that indicate preneoplastic or neoplastic conditions of the esophagus [ 26 , 27 , 28 , 29 ]. These findings can include nodularity, altered pit pattern or vascularity, depression, and protruding lesions, with upper endoscopy being recommended for esophageal cancer surveillance for individuals at high risk [ 30 ].…”

Section: Esophageal Cancermentioning

confidence: 99%

“…These findings can include nodularity, altered pit pattern or vascularity, depression, and protruding lesions, with upper endoscopy being recommended for esophageal cancer surveillance for individuals at high risk [ 30 ]. Accordingly, there are guidelines for screening of esophageal cancer in those at high risk, which in western countries focus primarily on surveilling for lesions associated with Barrett’s esophagus [ 26 , 27 , 28 , 29 ].…”

Section: Esophageal Cancermentioning

confidence: 99%

“…These cancers appeared as flat lesions in the first or second portion of the duodenum. Among three US cohort studies including a total of 825 individuals with Lynch syndrome, eight patients developed duodenal cancer [ 26 , 27 , 39 ]. Seven were duodenal adenocarcinomas and one was a neuroendocrine tumor.…”

Section: Duodenal Cancermentioning

confidence: 99%

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Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

Kumar

Farha

Burke

et al. 2022

Cancers

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Lynch syndrome is a common hereditary cancer predisposition syndrome associated with increased digestive cancer risk including colorectal, gastric, and duodenal cancers. While colorectal cancer surveillance is widely accepted to be an important part of a comprehensive Lynch syndrome risk management plan, the use of upper gastrointestinal cancer surveillance in Lynch syndrome remains more controversial. Currently, upper gastrointestinal cancer surveillance guidelines for Lynch syndrome vary widely, and there is no consensus on who should undergo upper gastrointestinal cancer surveillance, how surveillance should be performed, the age at which to initiate surveillance, or how often individuals with Lynch syndrome should undergo upper gastrointestinal cancer surveillance. Fortunately, research groups around the world have been focusing on upper gastrointestinal cancer surveillance in Lynch syndrome, and recent evidence in this field has demonstrated that upper gastrointestinal cancer surveillance can be performed with identification of precancerous lesions as well as early-stage upper gastrointestinal cancers. In this manuscript, we review the upper gastrointestinal cancer risks in Lynch syndrome, differing guideline recommendations for surveillance, outcomes of upper gastrointestinal cancer surveillance, and controversies in the field, and we provide a framework based on our collective experience with which to incorporate upper gastrointestinal cancer surveillance into a risk management program for individuals with Lynch syndrome.

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Section: Esophageal Cancermentioning

confidence: 99%

Section: Esophageal Cancermentioning

confidence: 99%

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Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

Kumar

Farha

Burke

et al. 2022

Cancers

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“…To date, numerous microbiome surveys have been conducted to identify the gut microbiome profile in IBD, especially focusing on the differences between the profile of IBD patients and that of healthy controls. Compelling studies in animal models and humans have provided evidence of persistent imbalance on the gut microbiome in IBD [ 29 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. However, it remains to be determined whether these changes in the microbiome are the cause of IBD or rather the result of inflammation after IBD onset.…”

Section: Gut Dysbiosis In Inflammatory Bowel Diseasementioning

confidence: 99%

The Interplay between Immune System and Microbiota in Inflammatory Bowel Disease: A Narrative Review

Aldars-García

Marín

Chaparro

et al. 2021

IJMS

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The importance of the gut microbiota in human health is currently well established. It contributes to many vital functions such as development of the host immune system, digestion and metabolism, barrier against pathogens or brain–gut communication. Microbial colonization occurs during infancy in parallel with maturation of the host immune system; therefore, an adequate cross-talk between these processes is essential to generating tolerance to gut microbiota early in life, which is crucial to prevent allergic and immune-mediated diseases. Inflammatory bowel disease (IBD) is characterized by an exacerbated immune reaction against intestinal microbiota. Changes in abundance in the gut of certain microorganisms such as bacteria, fungi, viruses, and archaea have been associated with IBD. Microbes that are commonly found in high abundance in healthy gut microbiomes, such as F. prausnitzii or R. hominis, are reduced in IBD patients. E. coli, which is usually present in a healthy gut in very low concentrations, is increased in the gut of IBD patients. Microbial taxa influence the immune system, hence affecting the inflammatory status of the host. This review examines the IBD microbiome profile and presents IBD as a model of dysbiosis.

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“…Studies have shown that the risk of esophageal cancer in patients with Barrett esophagus is 30 -120 times the risk in ordinary people (1,2). Therefore, it is of great significance to properly understand the risk factors of the transformation of Barrett esophagus into esophageal carcinoma to reduce the incidence of malignant tumors (3).…”

Section: Introductionmentioning

confidence: 99%

Experimental Study of the Effect of Helicobacter pylori Infection on Barrett Esophagus and Its Correlation with Immune Function

Zhang

Tan

Sun

et al. 2020

Jundishapur J Microbiol

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Background: Helicobacter pylori is an important pathogen in the upper digestive tract. It is of great significance to properly understand the risk factors for the transformation of Barrett esophagus into esophageal carcinoma. However, the relationship between H. pylori and gastroesophageal reflux disease (GERD) and Barrett esophagus remains controversial, and the correlation with immune function has been rarely reported. Objectives: This study investigated the effect of H. pylori infection on Barrett esophagus and its correlation with immune function. Methods: We recruited 40 patients with Barrett esophagus (Barrett esophagus group) and 40 patients with GERD (GERD group). In addition, 40 healthy controls were selected for the control group. Esophageal function and its correlation with immune function were measured in each group. Results: The positivity rate of H. pylori (P < 0.05) and sphincter pressure were lower in both Barrett esophagus and GERD groups than in the control group, while the levels of PGI, PGII, PGI/II, and G-17 were higher (P < 0.05). The levels of CD3+, CD4+, and CD4+/CD8+ were lower in the Barrett esophagus group than in the GERD group, but they were negatively correlated (P < 0.05) with H. pylori infection. The level of CD8+ was higher in the Barrett esophagus group, and it was positively correlated (P < 0.05) with H. pylori infection. Conclusions: Helicobacter pylori infection may protect against Barrett esophagus by reducing gastric acid secretion and increasing lower esophageal sphincter pressure. Besides, it has a certain correlation with immune function.

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Advanced imaging in surveillance of Barrett’s esophagus: Is the juice worth the squeeze?

Cited by 7 publications

References 31 publications

Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

The Interplay between Immune System and Microbiota in Inflammatory Bowel Disease: A Narrative Review

Experimental Study of the Effect of Helicobacter pylori Infection on Barrett Esophagus and Its Correlation with Immune Function

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