Advanced imaging of early rheumatoid arthritis

Tehranzadeh, Jamshid; Ashikyan, Oganes; Dascalos, Jane; Dennehey, Carolyn

doi:10.1016/j.mric.2004.07.003

Cited by 17 publications

(20 citation statements)

References 56 publications

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“…The benefits of MRI will be discussed further below. 10,13,21,36 In Table 1 we presented a summary of the advantages and disadvantages of each imaging modality used to evaluate cervical instabilities in the setting of RA.…”

Section: Overview Of Imaging Modalities For Diagnosing Cervical Instamentioning

confidence: 99%

“…36 MRI can provide information about the soft tissues, including the neural tissue (spinal cord and nerve roots) and the contents of the epidural space, and it is the modality of choice in evaluating spinal cord compression. The triplanar images obtained with MRI can also precisely document the craniocervical relationships, with direct visualization of facet subluxations, joint destruction, and dens dislocation.…”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

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Radiological evaluation of cervical spine involvement in rheumatoid arthritis

Af¹,

Ghizoni²,

Tedeschi³

et al. 2015

FOC

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Cervical spine involvement commonly occurs in patients with rheumatoid arthritis (RA), especially those with inadequate treatment or severe disease forms. The most common site affected by RA is the atlantoaxial joint, potentially resulting in atlantoaxial instability, with cervical pain and neurological deficits. The second most common site of involvement is the subaxial cervical spine, often with subluxation, resulting in nerve root or spinal cord compression. In this paper, the authors review the most commonly used plain radiographic criteria to diagnose cervical instabilities seen with RA. Finally, we discuss the advantages and disadvantages of cervical CT and MRI in the setting of cervical involvement in RA.

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Section: Overview Of Imaging Modalities For Diagnosing Cervical Instamentioning

confidence: 99%

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Radiological evaluation of cervical spine involvement in rheumatoid arthritis

Af¹,

Ghizoni²,

Tedeschi³

et al. 2015

FOC

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“…The activated synovial macrophages overexpress the folate receptor (FR) (10), while normal, noninflamed joint components do not express the FR (11). Therefore, FR-specific imaging is expected to provide a high sensitivity and specificity for the detection and characterization of synovitis in RA (2,(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Saborowski

Simon

Raatschen

et al. 2007

Contrast Media & Molecular

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The purpose of this study was to investigate if the new folate receptor-targeted Gd-chelate P866 may enhance immune-mediated arthritis. A monoarthritis was induced in the right knee of 15 Sprague-Dawley rats. MR imaging of both knees was performed at 2 T before and up to 2 h and 24 h after injection (p.i.) of P866 (n = 3 dose finding study and n = 6, 0.02 mmol Gd/kg), the non-FR targeted P866 analog P1001 (n = 3 at 24 h after P866-administration, 0.02 mmol Gd/kg) or Gd-DOTA (n = 6, 0.1 mmol Gd/kg). Pulse sequences comprised T(1)-SPGR 80 degrees /50 ms/1.7 ms (flip angle/TR/TE) and inversion recovery 10 degrees /3000 ms/1500 ms/50-3050, 10 000 ms (flip angle/TR/TE/TI) sequences. DeltaSI-data and T(1)-relaxation times of arthritic knees and contralateral normal knees were determined. Folate receptor expression was confirmed with histopathology. All three contrast agents showed an initial perfusion effect with significantly higher DeltaSI-data of arthritic knees compared with normal knees (p < 0.05). In addition, P866, but not P1001 or Gd-DOTA, showed a prolonged enhancement of the synovitis. Compared with precontrast values, the T(1)-relaxation times of inflamed synovia were significantly decreased at 2 h p.i. of P866 (p < 0.05), but not P1001 or Gd-DOTA (p > 0.05). Histopathology confirmed the presence of folate receptors in the inflamed joints, but not normal joints. Thus, results suggest a specific accumulation of the folate receptor-targeted Gd-chelate P866 in this arthritis model.

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“…Wrist, metacarpophalangeal and metatarsophalangeal joints are the first sites to be affected. [1][2][3][4][5][6][7][8][9][10] According to the epidemiological data, RA affects 1% of the population. While it shows a slow progression in some patients, in some it has a course characterized by rapid destruction of the bone and joint space.…”

mentioning

confidence: 99%

“…[13] Since then, a large number of publications using MRI in RA have demonstrated its usefulness in the detection of early period inflammatory and structural changes in RA cases. [1][2][3][4][5][6][7][8][9][10][11][12]14,15] Moreover, MRI is the ideal instrument for the evaluation of treatment response. [16] Since 1998, an international Outcome Measures in Rheumatology Clinical Trials (OMERACT) MRI in an RA working group has aimed to develop MRI scoring systems to assess RA inflammation (activity) and damage which would satisfy the elements of the OMERACT filter (truth, discrimination, and feasibility).…”

mentioning

confidence: 99%

Importance of MRI in Showing the Early Period Erosive Alterations During Wrist Involvement in Rheumatoid Arthritis

Gökalp

Yazıcı

2011

Turk J Rheumatol

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Amaç: Bu çalışmada, romatoid artritin (RA) erken dönem eroziv değişikliklerinin ortaya konmasında, manyetik resonans görüntülemenin (MRG) etkinliği değerlendirildi. Hastalar ve yöntemler:Klinik veriler ve laboratuvar sonuçlarıyla RA tanısı konulan 14 hastada (11 kadın, 3 erkek; ort yaş 54 yıl; dağılım 37-64 yıl) 21 el bileği MRG ile incelendi. Hastalık aktivitesi C-reaktif protein ve eritrosit sedimantasyon oranı ile belirlendi. Hastaların hepsinde el bileği grafisi normaldi ya da şüpheli bulgular vardı. Kemik erozyonlarının varlığı 15 farklı bölgede (8 karpal kemik, 5 metakarp başı, 1 distal radius ve 1 distal ulna) değerlendirildi. Yağ baskılamalı ve yağ baskılamasız koronal ve aksiyal T1-ağırlıklı spin eko (SE) görüntüleri, yağ baskılamalı T2-ağırlıklı koronal turbo SE görüntüleri ve intravenöz gadopentetat dimeglumin verilmesinden sonra yağ baskılamalı T1-ağırlıklı koronal SE görüntüleri elde edildi. Bulgular:Olguların hepsinde el bileği grafisi ya normaldi ya da şüpheli bulgular vardı. Karpal kemiklerde 73 (%81.1) farklı bölgede, distal radiusta dört (%4.4) farklı bölgede, distal ulnada dört (%4.4) farklı bölgede, proximal metakarp başlarında dokuz (%10) farklı bölgede kemik erozyonu tespit edildi. Kapitatum (%27.3) ve triquetrum (%24.6) en çok ekilenen bölge iken, pisiforme en az etkilenen bölge (%1.6) olarak tespit edildi. Erozyon saptanan 21 elbileği MRG'sinin dokuzunda (%42.8) sinovit, üçünde tenosinovit (%14.2), ikisinde bursit (%9.5) ve yedisinde kemik iliği ödemi (%33.3) vardı.Sonuç: Manyetik resonans görüntüleme RA'lı olgularda erken dönem eklem tutulumunu saptamada etkin bir tanı yöntemi olabilir.Anahtar sözcükler: Erozyon; manyetik rezonans görüntüleme; romatoid artrit. Objectives:In this study, we aimed to evaluate the efficacy of magnetic resonance imaging (MRI) in demonstrating erosive alterations during the early period of rheumatoid arthritis (RA). Patients and methods:Twenty-one wrists of 14 patients (11 females, 3 males; mean age 54 years; range 37 to 64 years) diagnosed with RA by clinical data and laboratory results were examined with MRI. The disease activity was determined by C-reactive protein and erythrocyte sedimentation rates. Wrist radiographies of all the patients were either normal or had suspicious signs. The presence of bone erosion was evaluated in 15 different regions (8 carpal bones, 5 metacarpal heads, 1 distal radius, and 1 distal ulna). Coronal and axial T1-weighted spin echo (SE) images with and without fat suppression, coronal T2-weighted turbo SE images with fat suppression, and coronal T1-weighted SE images with fat suppression following administration of intravenous gadopenteate dimeglumine were obtained. Results:In all cases, the wrist radiographs were either normal or exhibited suspicious findings. Bone erosion was found in 73 (81.1%) different sites in carpal bones, four different sites in distal radius (4.4%), four (4.4%) different sites in distal ulna, and nine (10%) different sites in proximal metacarpal heads. While capitatum (27.3%) and triquetrum (24.6%) wer...

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Advanced imaging of early rheumatoid arthritis

Cited by 17 publications

References 56 publications

Radiological evaluation of cervical spine involvement in rheumatoid arthritis

Radiological evaluation of cervical spine involvement in rheumatoid arthritis

MR imaging of antigen‐induced arthritis with a new, folate receptor‐targeted contrast agent

Importance of MRI in Showing the Early Period Erosive Alterations During Wrist Involvement in Rheumatoid Arthritis

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