Advanced Imaging of Multiple Myeloma Bone Disease

Hansford, Barry G.; Silbermann, Rebecca

doi:10.3389/fendo.2018.00436

Cited by 20 publications

(11 citation statements)

References 64 publications

(80 reference statements)

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“…In this retrospective analysis, we described 23 myeloma patients younger than 50 years of age. This cohort, mainly diagnosed in ISS stage I–II (79% of cases), showed a high frequency of bone lytic lesions (89%) [17], soft-tissue EMPs (26%) [18], and light-chain myeloma (45%) [19]. The PFS of the entire group was relatively short (median 12 months).…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience

et al. 2020

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Introduction: Multiple myeloma (MM) is uncommon in persons younger than 50 years of age. The presenting features in this age group are unclear. Methods: We analyzed a cohort of patients <50 years of age with MM treated in our center. Results: Twenty-three patients at a median age of 41.5 years (range 27–49) were analyzed. Patients presented at International Staging System (ISS) I–II (79%), had high frequency of bone lytic lesions (89%), extramedullary disease (26%), light-chain myeloma (45%), and translocation t(11;14) (68%). The subpopulation of patients carrying t(11;14) were younger (p = 0.025). This subgroup had higher bone marrow infiltration of plasma cells (75 vs. 47.5%), higher incidence of proteinuria (2.9 vs. 0.19 g/day), and poorer response to therapy: 85.7% of patients achieving complete/very good partial remission after induction therapy did not have t(11;14). A trend toward inferior progression-free survival (PFS) was observed in patients with t(11; 14) compared to patients without this translocation (median PFS 18 and 36 months, respectively). Discussion/Conclusion: Translocation t(11; 14) seems to be more prevalent in young myeloma patients. Young myeloma patients and especially those who harbor translocation t(11; 14) may represent a distinct clinical entity that confers a poor outcome.

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Section: Discussionmentioning

confidence: 99%

Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience

et al. 2020

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“…In a middle-aged patient, secondary bone metastasis is the most common and can appear in any radiologic image, with the appearance dependent on the type of primary cancer [26]. Conversely, bone lesions found with MM are distinct from those of other malignancies [27]. In MM, the typical appearance is purely osteolytic, resulting from an increase in osteoclastic (OCL) activity and a marked decrease in osteoblastic (OBL) activity [28].…”

Section: Discussionmentioning

confidence: 99%

Development of a clinical diagnostic tool to differentiate multiple myeloma from bone metastasis in patients with destructive bone lesions (MM-BM DDx)

et al. 2020

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Background Most patients with destructive bone lesions undergo a comprehensive diagnostic procedure to ensure that proper treatment decisions are pursued. For patients with multiple myeloma, this can lead to delays in diagnosis and treatment initiation. This study was conducted to develop a diagnostic rule that could serve as a tool for early identification of multiple myeloma and promote timely referral of patients to haematologists. Methods The clinical prediction rule was developed using a retrospective case-series of patients with multiple myeloma (MM) and those with bone metastasis (BM) at Chiang Mai University Hospital from 2012 to 2015. Multivariable fractional polynomial logistic regression was used to derive a diagnostic model to differentiate between MM and BM patients (MM-BM DDx). Results A total of 586 patients (136 MM patients and 450 BM patients) were included. Serum creatinine, serum globulin, and serum alkaline phosphatase were identified as significant indicators for the differentiation of MM and BM patients. The MM-BM DDx model showed excellent discriminative ability [AuROC of 0.90 (95%CI 0.86 to 0.93)] and good calibration. Conclusions This MM-BM DDx model could potentially allow for early myeloma diagnosis and improvement of overall prognosis. A prospective validation study is needed to confirm the accuracy of the MM-BM DDx model prior to its application in clinical practice.

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“…It is considered to represent the early stages of multiple myeloma (MM) and shows a predominantly lytic pattern (153). Bone disease in multiple myeloma patients is characterised by lytic bone lesions that can result in pathologic fractures and severe pain (154,155). Between 10% and 20% of patients with MM appear normal on radiography (156,157).…”

Section: Tumour Pathologymentioning

confidence: 99%

The role of radiography in the study of spinal disorders

Santiago¹,

Ramos‐Bossini²,

Wáng³

et al. 2020

Quant Imaging Med Surg

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Despite the growing use of computed tomography (CT) and magnetic resonance imaging (MRI) in the study of spinal disorders, radiography still plays an important role in many conditions affecting the spine. However, the study and interpretation of spine radiograph is receiving less attention and radiologists are increasingly unfamiliar with the typical findings in normal and pathologic conditions of the spine. The aim of this article is to review the radiologic indications of radiograph in different pathologic conditions that affect the spine, including congenital, traumatic, degenerative, inflammatory, infectious and tumour disorders, as well as their main radiographic manifestations.

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Advanced Imaging of Multiple Myeloma Bone Disease

Cited by 20 publications

References 64 publications

Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience

Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience

Development of a clinical diagnostic tool to differentiate multiple myeloma from bone metastasis in patients with destructive bone lesions (MM-BM DDx)

The role of radiography in the study of spinal disorders

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