Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions

Yang, Sen; Wang, Mengyi; Hua, Yuze; Li, Jiayi; Zheng, Huaijin; Cui, Ming; Huang, Nan; Liu, Qiaofei; Liao, Quan

doi:10.1016/j.canlet.2024.216610

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2024

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Cited by 5 publications

References 183 publications

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Single-cell technologies for dissecting heterogeneity in oral tumours: Implications for precision therapy

Vickram,

Saravanan,

Manikandan

2024

Oral Oncology Reports

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Single-cell technologies for dissecting heterogeneity in oral tumours: Implications for precision therapy

Vickram,

Saravanan,

Manikandan

2024

Oral Oncology Reports

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Identification of SUMOylation Biomarkers in Glioblastoma Based on Transcriptome and Mendelian Randomization Combined with Single-Cell RNA-Seq Analysis

Xiaodong,

Shun,

Kaihua

et al. 2024

Preprint

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Stanniocalcin-1 in tumor immunity: acts via macrophages

Wang,

Qiang

et al. 2024

Front. Immunol.

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Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis. Recently, STC1 is implicated in tumor microenvironment as a phagocytosis checkpoint, as well as regulates the immunity via macrophages. In the review, we discussed the role of STC1 and TAMs in tumor immunity and their crosstalk, hoping to provide references for the research of STC1 in tumor immunotherapy.

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Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular interactions

Cited by 5 publications

References 183 publications

Single-cell technologies for dissecting heterogeneity in oral tumours: Implications for precision therapy

Single-cell technologies for dissecting heterogeneity in oral tumours: Implications for precision therapy

Identification of SUMOylation Biomarkers in Glioblastoma Based on Transcriptome and Mendelian Randomization Combined with Single-Cell RNA-Seq Analysis

Stanniocalcin-1 in tumor immunity: acts via macrophages

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