This chapter indicates the overview of entrepreneurship; the overview of corporate entrepreneurship; the overview of internationalization; the overview of innovation; the associations among entrepreneurship, internationalization, and innovation; the importance of entrepreneurship in global business; the importance of internationalization in global business; and the importance of innovation in global business. Entrepreneurship is the important approach to enhancing the innovative procedures with the support of internationalization. Internationalization can help entrepreneurial companies effectively plan and execute the creative products and services in global business. Innovation involves various sophisticated methods and systems toward gaining increased productivity and business growth. The chapter argues that facilitating entrepreneurship, internationalization, and innovation has the potential to increase business performance and reach business goals in global business.