Nowadays, the implementation of virtual campuses is a reality, both in academic settings and in the workplace. However, there are several challenges associated with the implementation of effective learning outcomes via e-learning. In this chapter in particular, the use of e-learning to reach students with disabilities and the barriers that they may have will be presented. In this sense, e-learning solutions adopted by several institutions are encouraged to validate and promote accessibility in a virtual campus. " large myriad of research related to accessibility in distance education systems is available in literature, and the most relevant studies and standards are presented in this chapter as a starting point for education institutions looking at improving the accessibility in their own virtual campuses. This work is intended to be relevant both to teachers and lecturers who use e-learning for their courses, and to those involved in the design, setup, and maintenance of e-learning systems, whether from a pedagogical or technical perspective to take into account the accessibility for students with disabilities. This work will explore on the accessibility of the basic stone of the e-learning process, the learning objects. "n analysis of the IMS "f" v . specification will be presented as a starting point to develop an accessible and adaptable online course, based on the student's preferences, within an accessible virtual campus.