Advanced laser systems for photoacoustic imaging

Klosner, Marc; Sampathkumar, Ashwin; Chan, Gary; Wu, Chunbai; Groß, Daniel; Heller, Donald F.

doi:10.1117/12.2077780

Cited by 3 publications

(3 citation statements)

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“…4 It included several new features to address the specific requirements for optoacoustic imaging of the breast, including a higher pulse rate, operation at two wavelengths, and wavelength cycling. Here we describe improvements to the system that provide further benefit in a clinical setting, particularly: higher pulse energy to enable greater imaging depth and faster imaging at depth; a lower-profile configuration for compatibility with the architecture of optoacoustic imaging systems; and an enhanced computer interface to facilitate user operation.…”

Section: Light Agementioning

confidence: 99%

“…[1][2][3] Other imaging modalities such as ultrasound and MRI may be used adjunctively with mammography, but the benefits are not clear. 4 The emerging technology of optoacoustic imaging (OAI) has shown great promise for breast cancer diagnostics. It is capable of imaging vasculature deep within tissue, enabling quantitative assessment of biomarkers associated with tumor-related angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Advanced laser system for 3D optoacoustic tomography of the breast

Klosner

Chan

et al. 2016

SPIE Proceedings

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We describe the ongoing development and performance of a high-pulse-energy wavelength-cycling laser system for three-dimensional optoacoustic tomography of the breast. Joule-level energies are desired for achieving the required penetration depths while maintaining safe fluence levels. Wavelength cycling provides a pulse sequence which repeatedly alternates between two wavelengths (approximately 756 and 797 nm) that provide differential imaging. This improves co-registration of captured differential images and quantification of blood oxygen saturation. New design features have been developed for and incorporated into a clinical prototype laser system, to improve efficacy and ease of use in the clinic. We describe the benefits of these features for operation with a clinical pilot optoacoustic / ultrasound dual-modality three-dimensional imaging system.

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Section: Light Agementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Advanced laser system for 3D optoacoustic tomography of the breast

Klosner

Chan

et al. 2016

SPIE Proceedings

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“…A detailed review of current breast cancer imaging modalities and laser sources available for PAT systems has been discussed in the literature [4]. In this work, we demonstrate PAT of tissue-mimicking phantoms using a novel rapid-wavelength switching alexandrite laser.…”

Section: Introductionmentioning

confidence: 99%

3D noninvasive, high-resolution imaging using a photoacoustic tomography (PAT) system and rapid wavelength-cycling lasers

et al. 2015

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Globally, cancer is a major health issue as advances in modern medicine continue to extend the human life span. Breast cancer ranks second as a cause of cancer death in women in the United States. Photoacoustic (PA) imaging (PAI) provides high molecular contrast at greater depths in tissue without the use of ionizing radiation. In this work, we describe the development of a PA tomography (PAT) system and a rapid wavelength-cycling Alexandrite laser designed for clinical PAI applications. The laser produces 450 mJ/pulse at 25 Hz to illuminate the entire breast, which eliminates the need to scan the laser source. Wavelength cycling provides a pulse sequence in which the output wavelength repeatedly alternates between 755 nm and 797 nm rapidly within milliseconds. We present imaging results of breast phantoms with inclusions of different sizes at varying depths, obtained with this laser source, a 5-MHz 128-element transducer and a 128-channel Verasonics system. Results include PA images and 3D reconstruction of the breast phantom at 755 and 797 nm, delineating the inclusions that mimic tumors in the breast.

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