Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Shen, Yingnan; Gwak, Hogyeong; Han, Bumsoo

doi:10.1039/d3an01739g

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2024

DOI: 10.1039/d3an01739g

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Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Yingnan Shen,

Hogyeong Gwak,

Bumsoo Han

Abstract: Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.

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2024

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Cited by 4 publications

References 206 publications

(272 reference statements)

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Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction

Wang,

Wang

et al. 2024

International Journal of Biological Macromolecules

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Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction

Wang,

Wang

et al. 2024

International Journal of Biological Macromolecules

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The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

Arduino,

Andreana,

Sommonte

et al. 2024

Journal of Drug Delivery Science and Technology

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Size-Controllable and Monodispersed Lipid Nanoparticle Production with High mRNA Delivery Efficiency Using 3D-Printed Ring Micromixers

Hong,

Lee,

Park

et al. 2024

ACS Appl. Mater. Interfaces

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Lipid nanoparticles (LNPs) are gaining recognition as potentially effective carriers for delivery of therapeutic agents, including nucleic acids (DNA and RNA), for the prevention and treatment of various diseases. Much effort has been devoted to the implementation of microfluidic techniques for the production of monodisperse and stable LNPs and the improvement of encapsulation efficiency. Here, we developed three-dimensional (3D)-printed ring micromixers for the production of size-controllable and monodispersed LNPs with a high mRNA delivery efficiency. The effects of flow rate and ring shape asymmetry on the mixing performance were initially examined. Furthermore, the physicochemical properties (such as hydrodynamic diameter, polydispersity, and encapsulation efficiency) of the generated LNPs were quantified as a function of these physical parameters via biochemical analysis and cryo-electron microscopy imaging. With a high production rate of 68 mL/min, our 3D-printed ring micromixers can be used to manufacture LNPs with diameters less than 90 nm, low polydispersity (<0.2), and high mRNA encapsulation efficiency (>91%). Despite the simplicity of the ring-shaped mixer structure, we can produce mRNA-loaded LNPs with exceptional quality and high throughput, outperforming costly commercial micromixers.

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Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Abstract: Scaled-up production of nano-formulations is challenging. Find out how microfluidic manufacturing simultaneously meets the requirements for quality and throughput.

Cited by 4 publications

References 206 publications

Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction

Exploiting lignin-based nanomaterials for enhanced anticancer therapy: A comprehensive review and future direction

The manufacturing and characterization of pentamidine-loaded poly(lactic-co-glycolic acid) nanoparticles produced by microfluidic method

Size-Controllable and Monodispersed Lipid Nanoparticle Production with High mRNA Delivery Efficiency Using 3D-Printed Ring Micromixers

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