2013
DOI: 10.1016/j.addr.2012.10.003
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Advanced materials and processing for drug delivery: The past and the future

Abstract: Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Materials innovation and nanotechnology have synergistically fueled the advancement of drug delivery. Innovation in material chemistry allows the generation of biodegradable, biocompatible, environment-responsive, and targeted delivery systems. Nanotechnology enables control over size, shape and multi-functionality of particulate drug delivery systems. In this review, we focus on the materials innovatio… Show more

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Cited by 881 publications
(604 citation statements)
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“…The drug, which is stored in multiple reservoirs in liquid, gel or solid form, can be discharged by applying a potential difference between an anode membrane covering a reservoir and a cathode. How to fill their reservoirs aseptically, how to seal the reservoirs hermetically, how to achieve biocompatibility, and how to implant them through non-invasive surgery are some of the current difficulties associated with this class of implantable DDS [9,16,66,67]. Another important problem is that a membrane grows around the device once it is implanted in the body.…”
Section: Implantable Drug Delivery Systemsmentioning
confidence: 99%
See 1 more Smart Citation
“…The drug, which is stored in multiple reservoirs in liquid, gel or solid form, can be discharged by applying a potential difference between an anode membrane covering a reservoir and a cathode. How to fill their reservoirs aseptically, how to seal the reservoirs hermetically, how to achieve biocompatibility, and how to implant them through non-invasive surgery are some of the current difficulties associated with this class of implantable DDS [9,16,66,67]. Another important problem is that a membrane grows around the device once it is implanted in the body.…”
Section: Implantable Drug Delivery Systemsmentioning
confidence: 99%
“…Microchip-based DDS, also called 'pharmacy-on-a-chip' [9,16], which are fabricated using microtechnology and hard substrates such as silicon, glass and metallic thin films do not have moving parts such as pumps to release the drug [66,67]. The drug, which is stored in multiple reservoirs in liquid, gel or solid form, can be discharged by applying a potential difference between an anode membrane covering a reservoir and a cathode.…”
Section: Implantable Drug Delivery Systemsmentioning
confidence: 99%
“…This EPR allows particles with a certain size to enter and accumulate in tumor tissues. 7,10 The biocompatible polymers following unloading of the drug would eventually clear through the excretory system. Despite the ability of the EPR effect to improve the accumulation of drugs, there are several barriers to the EPR effect including high interstitial fluid pressure in tumor tissues, 2 layers of tissue penetration that is demanded for therapeutic drugs, and liver and spleen accumulation of these particles.…”
Section: Nanoparticles In Medicinementioning
confidence: 99%
“…Various nanotechnology has been developed to overcome these shortcomings (De Souza et al, 2010;Yamashita & Hashida, 2013;Zhang et al, 2013), but it seldom brought satisfactory therapeutic outcomes. A pioneering study emerged in the 1970s that successfully encapsulated b-glucosidase and b-galactosidase into red blood cells (RBCs) for the treatment of Gaucher's disease laid the foundation for future research and opened new avenue for cell-mediated drug delivery (Ihler et al, 1973).…”
Section: Introductionmentioning
confidence: 99%