Advanced materials for precise detection and antibiotic-free inhibition of bacteria

Liu, W.; Wang, R.; Vedarethinam, Vadanasundari; Huang, Lin; Qian, Kun

doi:10.1016/j.mtadv.2021.100204

Cited by 24 publications

(19 citation statements)

References 127 publications

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“…In recent decades, nanoparticles have been widely used in cancer diagnosis and treatment; they play a key role in nanomedicine. [51][52][53][54][55][56][57] Quantum dots (QDs) are utilized for the medical fluorescence labeling and imaging of nanomaterial because of their long-lasting fluorescence and excellent stability. [58] By adjusting particle size, multiple emissions could be calculated using the quantum dots.…”

Section: Synthesis and Characterization Of Quantum Dot-sorl1 Antibody...mentioning

confidence: 99%

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Chen

et al. 2023

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Exosomes are promising new biomarkers for colorectal cancer (CRC) diagnosis, due to their rich biological fingerprints and high level of stability. However, the accurate detection of exosomes with specific surface receptors is limited to clinical application. Herein, an exosome enrichment platform on a 3D porous sponge microfluidic chip is constructed and the exosome capture efficiency of this chip is ≈90%. Also, deep mass spectrometry analysis followed by multi‐level expression screenings revealed a CRC‐specific exosome membrane protein (SORL1). A method of SORL1 detection by specific quantum dot labeling is further designed and the ensemble classification system is established by extracting features from 64‐patched fluorescence images. Importantly, the area under the curve (AUC) using this system is 0.99, which is significantly higher (p < 0.001) than that using a conventional biomarker (carcinoembryonic antigen (CEA), AUC of 0.71). The above system showed similar diagnostic performance, dealing with early‐stage CRC, young CRC, and CEA‐negative CRC patients.

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Section: Synthesis and Characterization Of Quantum Dot-sorl1 Antibody...mentioning

confidence: 99%

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Chen

et al. 2023

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“…[19,20] Moreover, the matrix assisted laser desorption/ionization mass spectrometry (MALDI) is widely adopted in metabolite detections with enhanced sensitivity via the assistance of nanomaterials as matrices, which demonstrated huge potential for efficient screening of metabolic biomarkers toward practical clinical applications. [21][22][23][24] In this regard, the advanced screening technique for metabolic biomarkers awaits further exploration of selection and optimization of tailored matrix. [25][26][27] For noninvasive quantification of metabolic biomarkers in a wearable manner, biosensors based on electrochemistry (EC), [28,29] organic electrochemical transistors (OECTs), [30,31] and field effect transistors (FETs) [32,33] have been widely applied with the advantages of miniaturization, favorable sensitivity, selectivity, stability, reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High‐Throughput Screening of Metabolic Biomarkers and Wearable Biosensors for the Quantification of Metabolites

Zhang

Qian

2023

Advanced Sensor Research

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Metabolic biomarkers facilitate pathological/physiological investigations and clinic decisions. Noninvasive quantification of metabolic biomarkers allows patients to monitor their health without time, location, and environmental constraints. Recently, the synergistic integration between high-throughput screening strategy via mass spectrometry and noninvasive quantification techniques via wearable biosensors may provide fundamental insights into the application of metabolic biomarkers in clinical diagnostics. Here, mass spectrometry for the screening of metabolic biomarkers in several major clinical diseases (retinoblastoma, coronary heart disease, lung adenocarcinoma) is introduced. Then, three types of wearable biosensors based on electrochemistry, organic electrochemical transistors, and field effect transistors for the noninvasive quantification of metabolic biomarkers are summarized. The review may serve as a handbook for high-throughput screening of metabolic biomarkers and wearable biosensors for the quantification of metabolites. It is anticipated that biomarker discovery and quantification will facilitate the next generation of wearable biosensors toward personalized, intelligent, and precise home-healthcare on a large-scale.

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“…In recent years, the development of biosensors has provided new ideas for solving the above problems. Signal amplification biosensors based on electrochemistry, fluorescence, surface-enhanced raman scattering (SERS), molecular fingerprint platform, and mass spectrometry (MS) have been widely used in the detection of bacteria, temperature, heart rate, blood pressure, and glucose. − The electrochemical sensor based on alternating current (AC) impedance technology can directly use the implant’s surface as the electrode to monitor the surrounding environment of the implant, which has become a research hotspot in the construction of intelligent orthopedic implants. These techniques are based on detecting impedance changes in the system by applying a small electrical stimulation perturbation signal to the monitored bacteria.…”

Section: Introductionmentioning

confidence: 99%

Smart Implant with Bacteria Monitoring and Killing Ability for Orthopedic Applications

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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Bacterial infections around implants constitute a significant cause of implant failures. Early recognition of bacterial adhesion is an essential factor in preventing implant infections. Therefore, an implant capable of detecting and disinfecting initial bacterial adhesion is required. This study reports on the development of an intelligent solution for this issue. We developed an implant integrated with a biosensor electrode based on alternating current (AC) impedance technology to monitor the early growth process of Escherichia coli (E. coli) and its elimination. The biosensor electrode was fabricated by coating polypyrrole (PPy) doped with sodium p-toluenesulfonate (TSONa) on titanium (Ti) surfaces. Monitoring the change in resistance using electrochemical impedance spectroscopy (EIS), combined with an equivalent circuit model (ECM), enables the monitoring of the early adhesion of E. coli. The correlation with the classical optical density (OD) monitoring value reached 0.989. Subsequently, the eradication of bacteria on the electrode surface was achieved by applying different voltages to E. coli cultured on the electrode surface, which caused damage to E. coli. Furthermore, in vitro cellular experiments showed that the PPy coating has good biocompatibility and can promote bone differentiation.

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Advanced materials for precise detection and antibiotic-free inhibition of bacteria

Cited by 24 publications

References 127 publications

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

Construction of Exosome SORL1 Detection Platform Based on 3D Porous Microfluidic Chip and its Application in Early Diagnosis of Colorectal Cancer

High‐Throughput Screening of Metabolic Biomarkers and Wearable Biosensors for the Quantification of Metabolites

Smart Implant with Bacteria Monitoring and Killing Ability for Orthopedic Applications

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