Advanced maternal age and adverse pregnancy outcomes

Frick, Alexander

doi:10.1016/j.bpobgyn.2020.07.005

Cited by 138 publications

(96 citation statements)

References 56 publications

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“…The use of low-dose aspirin as a prophylaxis treatment to reduce PET incidence in AMA women 27 has been suggested by numerous authors.…”

Section: Resultsmentioning

confidence: 99%

“…Given that induction of labor at 39 weeks is considered a safe procedure with a low rate of adverse outcomes, it is reasonable to offer induction of labor at term pregnancy to AMA women, to reduce the stillbirth rate. 27 , 62 …”

Section: Resultsmentioning

confidence: 99%

“…24 Several possible mechanisms have been proposed for the association between AMA and the increased prevalence of PET, among them; decreased maternal hemodynamic adaptation during pregnancy, loss of compliance of the uterine blood vessels, and comorbid disease. 25,26 The use of low-dose aspirin as a prophylaxis treatment to reduce PET incidence in AMA women 27 has been suggested by numerous authors.…”

Section: Hypertension Disorders In Pregnancy and Pre-eclampsiamentioning

confidence: 99%

“…8 These findings are consistent with other studies. 27 A Korean study, which evaluates the association between AMA and chromosomal abnormalities, found a close correlation between trisomy 18 and 21 and maternal age. Above the age of 35, every increase in a year is associated with an increased risk of trisomy 18 and 21 by 1.182 and 1.177 times, respectively.…”

Section: Chromosomal Abnormalities and Congenital Anomaliesmentioning

confidence: 99%

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Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby

Glick

Kadish

Rottenstreich

2021

IJWH

112

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Pregnancy at advanced maternal age (age >35 years old) is considered a risk factor for adverse maternal and perinatal outcomes. Yet, pregnancies of advanced maternal age have become more prevalent over the last few decades. Possible maternal complications of pregnancy at age 35 or older include increased risk of spontaneous miscarriage, preterm labor, gestational diabetes mellitus, pre-eclampsia, stillbirth, chromosomal abnormalities, and cesarean delivery. Possible adverse fetal outcomes include infants small for gestational age and intrauterine growth restrictions, low Apgar score, admission to neonatal intensive care units, and an autism spectrum disorder. This paper aims to present an up-to-date review of the literature, summarizing the most current studies and implications for the management of pregnancy of advanced maternal age.

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“…The use of low-dose aspirin as a prophylaxis treatment to reduce PET incidence in AMA women 27 has been suggested by numerous authors.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Hypertension Disorders In Pregnancy and Pre-eclampsiamentioning

confidence: 99%

Section: Chromosomal Abnormalities and Congenital Anomaliesmentioning

confidence: 99%

See 2 more Smart Citations

Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby

Glick

Kadish

Rottenstreich

2021

IJWH

112

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“…imprinting | nc886 | oocyte M aternal age and environmental exposures during pregnancy are known to affect the developing child and have been extensively studied (1,2). In utero exposures to teratogens, drugs, alcohol, cigarettes, and maternal diet, particularly folic acid, can severely affect early human embryonic development, showing that this phase is sensitive to perturbation (1,(3)(4)(5)(6). However, the preconception time period, specifically the ∼6-mo interval of oocyte maturation, is also a unique window when maternal characteristics and behavior could impact oogenesis and therefore health outcomes in children.…”

mentioning

confidence: 99%

Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA ( nc886 )

Carpenter

Remba

Thomas

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Genomic imprinting occurs before fertilization, impacts every cell of the developing child, and may be sensitive to environmental perturbations. The noncoding RNA, nc886 (also called VTRNA2-1) is the only known example of the ∼100 human genes imprinted by DNA methylation, that shows polymorphic imprinting in the population. The nc886 gene is part of an ∼1.6-kb differentially methylated region (DMR) that is methylated in the oocyte and silenced on the maternal allele in about 75% of humans worldwide. Here, we show that the presence or absence of imprinting at the nc886 DMR in an individual is consistent across different tissues, confirming that the imprint is established before cellular differentiation and is maintained into adulthood. We investigated the relationships between the frequency of imprinting in newborns and maternal age, alcohol consumption and cigarette smoking before conception in more than 1,100 mother/child pairs from South Africa. The probability of imprinting in newborns was increased in older mothers and decreased in mothers who drank alcohol before conception. On the other hand, cigarette smoking had no apparent relationship with the frequency of imprinting. These data show an epigenetic change during oocyte maturation which is potentially subject to environmental influence. Much focus has been placed on avoiding alcohol consumption during pregnancy, but our data suggest that drinking before conception may affect the epigenome of the newborn.

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Maternal age and adverse pregnancy outcomes among Meitei women of Manipur, Northeast India: A cross‐sectional study

Devi,

Singh

2023

American J Hum Biol

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ObjectiveThe study examines the outcomes of pregnancies conceived at advanced maternal age (AMA) and maternal complications after childbirth among Meitei women of Northeast India.MethodA total of 760 women participants were included in this study and compared among women aged ≥35 years, with a reference group of women aged 20–34 years. Data on obstetric characteristics were collected after obtaining consent. The data were compared using chi‐square analysis, and the results were adjusted using a logistic regression model. Decision trees were developed to predict the potential variables associated with preterm delivery and postpartum complication.ResultsIn the study, 18.95% of AMA women experienced one or more adverse pregnancy outcomes (APOs). Women with AMA are at significantly increased risk of placenta previa (adjusted odds ratio [AOR] = 4.89, 95% confidence interval [CI]: 2.78–8.57), induction of labor (AOR = 3.69, 95%CI: 2.48–5.50), and caesarean section (AOR = 3.42, 95%CI: 2.28–5.12). Moreover, AMA women have a 1.86–2.76 AOR for developing gestational diabetes, pregnancy‐induced hypertension, urinary tract infections, preterm delivery, and postpartum complications. Decision tree analysis revealed that AMA and urban residence independently predict preterm delivery and postpartum complications.ConclusionThe study's findings confirm the adverse impact of AMA on pregnancy outcomes and postpartum complications. Such issues should be addressed, and counseling on the risk of AMA should be provided, particularly for those in the high‐risk group. Further prospective studies are needed to understand other potential risk factors of APOs and the impact of AMA complications to prevent the associated burden.

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Advanced maternal age and adverse pregnancy outcomes

Cited by 138 publications

References 56 publications

Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby

Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby

Oocyte age and preconceptual alcohol use are highly correlated with epigenetic imprinting of a noncoding RNA ( nc886 )

Maternal age and adverse pregnancy outcomes among Meitei women of Manipur, Northeast India: A cross‐sectional study

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