Advanced maternal age and the impact on maternal and offspring cardiovascular health

Cooke, Christy‐Lynn M.; Davidge, Sandra T.

doi:10.1152/ajpheart.00045.2019

Cited by 73 publications

(63 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding sociodemographic features, women with unfulfilled reproductive desires were younger than women with fulfilled reproductive desires. The possibility of completing reproductive desires increases over the years [ 42 ], so an age difference between the two groups had been expected. The proportion of women with completed mandatory education level was higher in women with unfulfilled reproductive desires.…”

Section: Discussionmentioning

confidence: 99%

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Montero‐Vílchez

Salvador‐Rodríguez

Rodriguez-Tejero

et al. 2021

Life

View full text Add to dashboard Cite

There are scarce data available regarding the impact of hidradenitis suppurativa (HS) on fertility, course and outcome of pregnancy and risk associated with treatments. The aims of this study are (1) to describe the clinical profile of HS women of childbearing age with and without accomplished reproductive desires and (2) to describe the prescribed treatments based on the fulfillment of reproductive intentions. We conducted a prospective observational study that included 104 HS women of childbearing age, 50.96% (53/104) with unfulfilled reproductive desires. These women were younger (29.08 vs. 42.06 years, p < 0.001), less frequently married and higher educated than women with fulfilled reproductive desires. Their age of disease onset was lower, but disease duration was shorter, in concordance with a lower International Hidradenitis Suppurativa Severity Score System (IHS4) and lower number of draining tunnels. Combined oral contraceptives were more frequently prescribed in women with unfulfilled reproductive desires (30.19% vs. 9.80%, p = 0.013) while biologics were less used in this group (3.77% vs. 13.73%, p = 0.08). In conclusion, a higher educational level and an earlier disease onset, with potential implications in finding a partner, may make the fulfillment of reproductive desires difficult for patients with HS. This study could help clinicians to achieve a better understanding of the specific characteristics of HS during childbearing age and consider reproductive desires when making treatment decisions.

show abstract

Section: Discussionmentioning

confidence: 99%

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Montero‐Vílchez

Salvador‐Rodríguez

Rodriguez-Tejero

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…Maternal age at delivery, 24 maternal smoking status during the first 3 months of pregnancy, [25][26][27] maternal socioeconomic status (SES), paternal SES, maternal highest education attainment, and paternal highest education attainment 11,[28][29][30] were identified as possible confounders ( Figure 1) and adjusted for in all analyses. The above variables were chosen based on previous literature and availability in present dataset.…”

Section: Descriptive and Confounding Variablesmentioning

confidence: 99%

Maternal obesity before pregnancy predicts offspring blood pressure at 18 years of age: A causal mediation analysis

Brunton

Dufault

Dart

et al. 2020

Preprint

View full text Add to dashboard Cite

ImportanceHypertension is the second most common pediatric chronic disease in Westernized countries. Understanding the natural history of hypertension is key to identifying prevention strategies.ObjectiveExamine the relationship between maternal pre-pregnancy body mass index (BMI) and offspring blood pressure at 18 years and the mediating role of growth throughout childhood and adolescence.Design, Setting, and ParticipantsWe performed multivariable regression and causal mediation analyses within 3217 mother - offspring pairs from the Avon Longitudinal Study of Parents and Children (ALSAPC) prospective birth cohort. Latent trajectory analysis (LTA) was used to quantify the mediating variable of offspring BMI from 7 to 18 years of age.ExposuresThe main exposure was maternal pre-pregnancy BMI. Analyses were adjusted for relevant confounders including maternal education, maternal blood pressure, and weeks gestation at delivery.Main Outcomes and MeasuresThe main outcome was offspring blood pressure at 18 years of age categorized as normal (SBP < 120 mmHg or DBP < 80mmHg) or elevated (SBP ≥ 120 mmHg or DBP ≥ 80 mmHg) as per the 2017 American Academy of Pediatrics guidelines.ResultsAt 18 years of age, among 3217 offspring, 676 (21%) were overweight or obese, 865 (27%) had elevated blood pressure, and 510 (16%) were hypertensive. LTA identified five distinct offspring BMI trajectories. Multivariate logistic regression revealed that for every 1 unit increase in maternal BMI the risk of elevated blood pressure at 18 years of age increased by 5% (aOR: 1.05, 95% CI: 1.03 – 1.07; p <0.001) and this effect was reduced after adjusting for offspring BMI trajectory (aOR: 1.03, 95% CI: 1.00 – 1.05; p = 0.017). Causal mediation analysis confirmed offspring BMI trajectory as a mediator accounting for 46% of the total effect of maternal BMI on elevated offspring blood pressure (aOR 1.22; 95% CI: 1.07-1.39).Conclusion and RelevanceMaternal BMI prior to pregnancy is associated with an increased risk of elevated blood pressure in offspring at 18 years of age and is mediated, in part, by offspring BMI trajectory throughout childhood and adolescence.

show abstract

“…While previous studies have demonstrated the association of PE development in pregnant women and future cardiovascular complications such as the development of hypertension, diabetes, ischemic disease, and other cardiovascular diseases, recent literature has suggested the need for additional studies for a more complete understanding of how this relationship is established (7)(8)(9)(10)(11).…”

Section: ' Introductionmentioning

confidence: 99%

Previous preeclampsia and its association with the future development of cardiovascular diseases: a systematic review and meta-analysis

Veiga¹,

Rocha²,

Caviola³

et al. 2021

Clinics

View full text Add to dashboard Cite

Preeclampsia is a multifactorial disease. Among these factors, untreated hypertension during pregnancy can result in high morbidity and mortality rates and may also be related to the future development of cardiovascular diseases.Therefore, this systematic review aimed to determine the association of previous preeclampsia with the future development of cardiovascular diseases. Studies on the association between preeclampsia and future cardiovascular diseases published in the last 10 years (2009-2019) were identified from the PubMed/Medline (207 articles), Embase (nine articles), and Cochrane (three articles) databases using the keywords “preeclampsia” and “future cardiovascular diseases”, “preeclampsia” and “future heart attack”, and “preeclampsia” and “future cardiac disease”. After applying the inclusion and exclusion criteria, 15 articles were analyzed by systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The meta-analysis and the determination of the quality of the articles were conducted using RevMan software, version 5.3. Statistically significant differences were observed between the control and previous preeclampsia groups with respect to systolic blood pressure (mean difference [MD] 4.32; 95% confidence interval [95%CI] 3.65, 4.99; p <0.001), diastolic blood pressure (MD): 2.11; 95%CI: 1.68, 2.55; p <0.0001), and insulin level (MD: 2.80; 95% CI: 0.50, 5.11; p <0.001). Body mass index (MD: 2.57, 95%CI: 2.06, 3.07; p =0.0001), total cholesterol (MD: 10.39; 95%CI: 8.91, 11.87; p =0.0001), HDL (MD: 2.83; 95%CI: 2.20, 3.46; p =0.0001), and LDL (MD: 1.77; 95%CI: 0.42, 3.13; p =0.0001) also differed significantly between groups. Thus, the results of the present study showed that women with a history of preeclampsia were more likely to develop cardiovascular disease.

show abstract

Advanced maternal age and the impact on maternal and offspring cardiovascular health

Cited by 73 publications

References 79 publications

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Reproductive Potential and Outcomes in Patients with Hidradenitis Suppurativa: Clinical Profile and Therapeutic Implications

Maternal obesity before pregnancy predicts offspring blood pressure at 18 years of age: A causal mediation analysis

Previous preeclampsia and its association with the future development of cardiovascular diseases: a systematic review and meta-analysis

Contact Info

Product

Resources

About