Advanced modalities of molecular imaging in precision medicine for musculoskeletal malignancies

Abstract

Musculoskeletal malignancies consist of a heterogenous group of mesenchymal tumors, often with high inter- and intratumoral heterogeneity. The early and accurate diagnosis of these malignancies can have a substantial impact on optimal treatment and quality of life for these patients. Several new applications and techniques have emerged in molecular imaging, including advances in multimodality imaging, the development of novel radiotracers, and advances in image analysis with radiomics and artificial intelligence. This review highlights the recent advances in molecular imaging modalities and the role of non-invasive imaging in evaluating tumor biology in the era of precision medicine.

Artificial intelligence in musculoskeletal oncological radiology

“…On the other hand, “imaging is not an isolated measure of disease.” 13 Neoplastic lesions are complex conditions, following DNA mutations that cause abnormal cellular proliferation. 50 Despite many mutations being discovered and related to specific malignancies, intertumoural and intratumoural heterogeneity exist. 51 Undoubtedly, molecular approaches, like genetic biomarkers and molecular imaging have already significantly contributed to a better understanding of cancer management.…”