Advanced MRI for carotid plaque imaging

Singh, Navneet; Moody, Alan R.; Roifman, Idan; Bluemke, David A.; Zavodni, Anna

doi:10.1007/s10554-015-0743-6

Cited by 44 publications

(21 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MRI will also allow assessment of several secondary outcomes that are surrogate markers of CVD: changes in intraplaque haemorrhage, lipid-rich necrotic core and carotid artery calcium status, 37 38 45 46 each of which has an intraclass correlation value for measurements above 0.9 (good to excellent). 42 44 …”

Section: Methods and Analysismentioning

confidence: 99%

Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial

et al. 2016

View full text Add to dashboard Cite

IntroductionType 2 diabetes (T2DM) produces macrovascular and microvascular damage, significantly increasing the risk of cardiovascular disease (CVD), renal failure and blindness. As rates of T2DM rise, the need for effective dietary and other lifestyle changes to improve diabetes management become more urgent. Low-glycaemic index (GI) diets may improve glycaemic control in diabetes in the short term; however, there is a lack of evidence on the long-term adherence to low-GI diets, as well as on the association with surrogate markers of CVD beyond traditional risk factors. Recently, advances have been made in measures of subclinical arterial disease through the use of MRI, which, along with standard measures from carotid ultrasound (CUS) scanning, have been associated with CVD events. We therefore designed a randomised, controlled, clinical trial to assess whether low-GI dietary advice can significantly improve surrogate markers of CVD and long-term glycaemic control in T2DM.Methods and analysis169 otherwise healthy individuals with T2DM were recruited to receive intensive counselling on a low-GI or high-cereal fibre diet for 3 years. To assess macrovascular disease, MRI and CUS are used, and to assess microvascular disease, retinal photography and 24-hour urinary collections are taken at baseline and years 1 and 3. Risk factors for CVD are assessed every 3 months.Ethics and disseminationThe study protocol and consent form have been approved by the research ethics board of St. Michael's Hospital. If the study shows a benefit, these data will support the use of low-GI and/or high-fibre foods in the management of T2DM and its complications.Trial Registration numberNCT01063374; Pre-results.

show abstract

Section: Methods and Analysismentioning

confidence: 99%

Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Stable plaques are type VII (calcified plaque) and type VIII (fibrous plaque) in the classification of AS plaques. The MRI signals of type VII plaques showed low signals in T1WI, T2WI and PDWI; type VIII plaques showed iso-signal or high signal on T1WI, slightly high or iso-signal on PDWI and slightly high signal or isosignal on T2WI (20). As a noninvasive method, HR-MRI can comprehensively evaluate the functions and morphologies of different types of plaques and then determine the potential rupture risks of different types of plaques.…”

Section: Perioperative Preparationmentioning

confidence: 98%

Predictive values of carotid high-resolution magnetic resonance imaging for large embolus shedding in carotid artery stenting

2021

Turk J Med Sci

View full text Add to dashboard Cite

Predictive values of carotid high-resolution magnetic resonance imaging for large embolus shedding in carotid artery stenting Background/aim: Embolus shedding is one of the important complications in carotid artery stenting (CAS). Carotid high-resolution magnetic resonance imaging (HR-MRI) is often used to directly reflect important biological characteristics, such as plaque size and composition, as well as the structure of the carotid artery wall. The aim of this study was to investigate the predictive values of carotid HR-MRI for large embolus shedding in CAS. Materials and methods: In total, 195 patients with carotid stenosis were enrolled. Preoperative carotid HR-MRI was performed to define the nature of the carotid plaques. CAS was performed in all patients, and intraoperative embolic protection devices were used to collect the shed emboli. According to the diameter and number of shed emboli, the patients were divided into the small-embolus group (group X) and large-embolus group (group Y). Logistic regression analysis was used to analyze the risk factors of large embolus shedding. Results: Group Y included 58 patients, and group X included 137 patients. Age, stenosis length, smoking, and ≥3 transient cerebral ischemic attacks were risk factors for large embolus shedding. Two cases of shed large emboli developed from stable plaques, and 56 cases of large emboli developed from vulnerable plaques. When vulnerable plaques were associated with more risk factors, the incidences of large embolus shedding in cases with vulnerable plaques combined with 0, 1, 2, 3, and 4 risk factors were 44 % (4/9), 68.1% (15/22), 72.2% (13/18), 76.5% (13/17), and 84.6% (11/13), respectively. Conclusion: Carotid HR-MRI can predict the incidence of large embolus shedding in 2 CAS.

show abstract

“…A range of MR techniques have been developed with specific technical advantages for imaging of different components of the plaque (22). Examples of different MR imaging techniques are shown in Fig.…”

Section: Magnetic Resonance Angiographymentioning

confidence: 99%

Imaging the carotid atherosclerotic plaque

et al. 2019

View full text Add to dashboard Cite

This mini review provides a concise overview of imaging techniques that are currently used to image the atheroscletoric plaque in the carotid artery in vivo. The main techniques include ultrasound imaging, X-ray imaging, magnetic resonance imaging and positron emission tomography imaging. Each technique has advantages and limitations and may be chosen depending on the availability, cost and clinical justification for its use. Common to all the imaging techniques presented here is the need for a skilled imaging professional to allow for high reliability and repeatability. While ultrasound-based imaging currently is regarded as a first line technique in clinical practice, the use of other techniques such as computed tomography angiography or magnetic resonance angiography need to be considered in the presence of significant stenosis with or without symptoms. Advancements in these two modalities, as well as in positron emission tomography imaging, are increasingly moving toward a better understanding of the risk-stratification and pre-interventional monitoring of patients at risk of plaque rupture as well as early identification of plaque development and better understanding of plaque composition (e.g. metabolic imaging).

show abstract

Advanced MRI for carotid plaque imaging

Cited by 44 publications

References 64 publications

Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial

Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trial

Predictive values of carotid high-resolution magnetic resonance imaging for large embolus shedding in carotid artery stenting

Imaging the carotid atherosclerotic plaque

Contact Info

Product

Resources

About