Multi-focus image fusion (MIF) uses fusion rules to combine two or more images of the same scene with various focus values into a fully focused image. An all-in-focus image refers to a fully focused image that is more informative and useful for visual perception. A fused image with high quality is essential for maintaining shift-invariant and directional selectivity characteristics of the image. Traditional wavelet-based fusion methods, in turn, create ringing distortions in the fused image due to a lack of directional selectivity and shift-invariance. In this paper, a classical MIF system based on quarter shift dual-tree complex wavelet transform (qshiftN DTCWT) and modified principal component analysis (MPCA) in the laplacian pyramid (LP) domain is proposed to extract the focused image from multiple source images. In the proposed fusion approach, the LP first decomposes the multi-focus source images into low-frequency (LF) components and high-frequency (HF) components. Then, qshiftN DTCWT is used to fuse low and high-frequency components to produce a fused image. Finally, to improve the effectiveness of the qshiftN DTCWT and LP-based method, the MPCA algorithm is utilized to generate an all-in-focus image. Due to its directionality, and its shift-invariance, this transform can provide high-quality information in a fused image. Experimental results demonstrate that the proposed method outperforms many state-of-the-art techniques in terms of visual and quantitative evaluations.