Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Kurilchik, S. V.; Gacci, Mauro; Cicchi, Riccardo; Pavone, Francesco S.; Morselli, Simone; Serni, Sergio; Chou, Ming-Chieh; Närhi, Mikko; Rafailov, Edik U.; Stewart, Neil J.; Lennon, Cordelia; Gumenyuk, Regina

doi:10.1088/2515-7647/ab7bab

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…In medical surgery, due to water absorption local minima in this wave band mean preferential targeting of lipidrich tissue can be achieved [4]. Three-photon microscopy (3PM) at this wavelength band, compared with commonly used first (650-950 nm) and second (1100-1350 nm) biological windows, has the merits of reduced scattering (thus deeper penetration depth into tissue), improved signal-to-noise ratio (SNR), and diminished phototoxicity [5]. A tunable laser source is of particular interest as it can be used to select the optimal wavelength and increases the number of accessible fluorophores in 3PM.…”

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confidence: 99%

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Liu¹,

Sahu

Gumenyuk

2023

Opt. Lett.

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In this Letter, we demonstrate an ultrabroadband (1700–1900 nm) tunable Tm-doped fiber laser (TDFL) generating dissipative solitons in the net-normal dispersion regime. The laser delivers pulses with spectral widths ranging from 10 nm to 23 nm and pulse durations from 8.7 ps to 18.3 ps. Stretched-free pulse amplification at the gain edge (1708 nm) and gain peak (1807 nm) is implemented to demonstrate the range of further power scalability of the laser signal. The maximum achieved power in a one-stage Tm-doped amplifier is 140 mW with a compressed pulse duration of 478 fs. Considering the diverse utility of this wavelength band, this laser is highly desirable for applications such as optical sensing, biological imaging, and industrial machining.

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confidence: 99%

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Liu¹,

Sahu

Gumenyuk

2023

Opt. Lett.

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“…To our knowledge, this is the first report of a tunable CPA system in this wavelength region. This tunable CPA system was originally built for the European Union Horizon 2020 project-Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy (AMPLITUDE) [39], and it can work as a versatile laser source for different applications.…”

Section: Introductionmentioning

confidence: 99%

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Liu,

Gumenyuk

2024

Photonics

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Chirped pulse amplification (CPA) has been a commonly used methodology to obtain powerful ultrashort laser pulses ever since its first demonstration. However, wavelength-tunable CPA systems are much less common. Wavelength-tunable ultrashort and intense laser pulses are desirable in various fields such as nonlinear spectroscopy and optical parametric amplification. In this work, we report a 1720 nm–1800 nm tunable CPA system based on Tm-doped fiber. The tunable CPA system contains a seed laser, a pulse stretcher, two cascaded amplifiers and a pulse compressor. The dispersion-managed seed laser cavity emits wavelength-tunable laser pulses with pulse durations of several ps and spectral widths from 25 nm to 34 nm. After being stretched temporally to tens of ps, the laser pulses are then amplified in two-stage amplifiers and compressed in a Treacy-type compressor. At 1720 nm, the maximum average power of 126 mW is obtained with a pulse duration of 507 fs; at 1800 nm, the maximum average power of 264 mW is obtained with a pulse duration of 294 fs. The pulse repetition rates are around 22.7 MHz. We perform an analysis of the system design based on numerical simulations and go on to suggest further steps for improvement. To the best of our knowledge, this is the first demonstration of a tunable CPA system beyond 1.1 μm. Considering the specific wavelength range, this wavelength-tunable CPA system is highly desirable for biomedical imaging, sensing, and parametric amplifiers.

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A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

Castro-Olvera,

Baria,

Stoliarov

et al. 2024

J. Phys. Photonics

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For a long time, it has been known that optics can provide a broad range of tools for addressing clinical needs, particularly diagnostics. Optical techniques can help in identifying diseases and detecting pathological tissues with non/minimally invasive and label-free methods. Given the current limitations of standard clinical procedures, such an approach could provide a powerful tool in detecting gastrointestinal and bladder cancers. However, each technique has serious limitations regarding one or more of the following features: biomarker sensitivity, penetration depth, acquisition times, or adaptation to the clinical environment. Hence there is an increasing need for approaches and instruments based on the concept of multimodality; in this regard, we review the application of different imaging/spectroscopy tools and methods operating in the first two optical windows (SHG, SPEF, TPEF, THG, 3PEF, CARS, Raman and reflectance) for tumour detection in the digestive and urinary systems. This article also explores the possibility of exploiting the third bio-tissue transmission window (1600-1900 nm) by reviewing state of the art in ultrafast laser sources development. Finally, we summarise the most recent results in developing multiphoton endoscopes – a key element for clinical in vivo translation of photonics-based diagnostics.

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Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Cited by 6 publications

References 28 publications

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Tunable dissipative soliton Tm-doped fiber laser operating from 1700 nm to 1900 nm

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems

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