Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression

Ghorbanzadeh, Fatemeh; Jafari-Gharabaghlou, Davoud; Dashti, Mohammad; Hashemi, Mehrdad; Zarghami, Nosratollah

doi:10.1007/s12032-023-02120-8

Med Oncol

2023

DOI: 10.1007/s12032-023-02120-8

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Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression

Fatemeh Ghorbanzadeh

Davoud Jafari-Gharabaghlou

Mohammad Dashti

et al.

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Cited by 6 publications

References 44 publications

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Hippophae Rhamnoides‐derived Phytomedicine Nano‐System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple‐Negative Breast Cancer

Farheen,

Iqbal,

Mushtaq

et al. 2024

Adv Healthcare Materials

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Triple‐negative breast cancer (TNBC) is the most common primary tumor of the breast with limited effectual drug availability. Therefore, the aim of the study is to develop an innovative phyto‐nanomedicine (PNM) to cure TNBC with the least genotoxicity. Hereinafter, the sea buckthorn’ extracted polyphenols (SBP), combine with metformin (MET), are synthesized as a novel PNM to evaluate its anti‐tumor properties, effectiveness, and mechanism of action in TNBC in vitro and in vivo models. The SBP exhibits 16 new kinds of polyphenols that are been reported earlier which regulated cell development, proliferation, and programmed cell death (PCD) effectively. SBP‐MET PNM inhibits MDA‐MB‐231 (47%), MDA‐MB‐436 (46%), and 4T1 (46%) cell proliferation but does not affect L929 normal murine cell development and successfully induce PCD (73.19%) in MDA‐MB‐231 cells. Mechanistically, in vivo SBP‐MET proteome expression profiling reveals upregulation of proapoptotic Bax protein and activation of Fas signaling pathways convince downstream Daxx and FADD proteins, which further triggers Caspase‐3 that prompts apoptosis in human TNBC cells by cleaving PARP‐1 protein. Current findings establish innovative highly biocompatible phyto‐nanomedicine that has significant potential to inhibit TNBC cell growth and induce regulated cell death (RCD) in vivo model, thereby opening a new arena for TNBC therapy.

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Hippophae Rhamnoides‐derived Phytomedicine Nano‐System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple‐Negative Breast Cancer

Farheen,

Iqbal,

Mushtaq

et al. 2024

Adv Healthcare Materials

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show abstract

Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells

Abdulkareem,

Jafari-Gharabaghlou,

Farhoudi-Sefidan-Jadid

et al. 2024

DARU J Pharm Sci

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Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells

Abdulzehra,

Jafari-Gharabaghlou,

Zarghami

2023

Heliyon

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Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression

Cited by 6 publications

References 44 publications

Hippophae Rhamnoides‐derived Phytomedicine Nano‐System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple‐Negative Breast Cancer

Hippophae Rhamnoides‐derived Phytomedicine Nano‐System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple‐Negative Breast Cancer

Co-delivery of artemisinin and metformin via PEGylated niosomal nanoparticles: potential anti-cancer effect in treatment of lung cancer cells

Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells

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