2021
DOI: 10.1002/anbr.202000063
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Advanced Nanobiomedical Approaches to Combat Coronavirus Disease of 2019

Abstract: New infectious diseases are making themselves known as the human population grows, expands into new regions, and becomes more dense, increasing contact with each other and animal populations. Ease of travel has also increased infectious disease transmission and has now culminated into a global pandemic. The emergence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in December 2019 has already infected over 83.7 million people and caused over 1.8 million deaths. While there… Show more

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Cited by 5 publications
(5 citation statements)
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References 115 publications
(273 reference statements)
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“…However, in the case of SARS-CoV-2, they induce rather low neutralizing responses, an observation compatible with the fact that most individuals infected with virus mount relatively low antibody responses despite sometimes rather high viral load. The same argument extends to attenuated viruses [16][17][18]. Adenoviruses-based vaccines targeting COVID-19 can easily be produced at large scale and can also be stored at conventional temperature (4 • C).…”
Section: Introductionmentioning
confidence: 91%
“…However, in the case of SARS-CoV-2, they induce rather low neutralizing responses, an observation compatible with the fact that most individuals infected with virus mount relatively low antibody responses despite sometimes rather high viral load. The same argument extends to attenuated viruses [16][17][18]. Adenoviruses-based vaccines targeting COVID-19 can easily be produced at large scale and can also be stored at conventional temperature (4 • C).…”
Section: Introductionmentioning
confidence: 91%
“…Exosomes are particularly promising due to their cell membrane proteins and natural cargo of nucleic acids, proteins, and lipids, meaning exosomes display parent cell-specific targeting and functions (Popowski et al, 2020). These particles' biocompatible membranes are also able to avoid immune recognition and reduce toxic effects (Lutz et al, 2021). Furthermore, exosome surfaces can be engineered to display ligands for improved targeting and controlled release and their cargo can be altered to carry pharmaceutical drugs (Lutz et al, 2019).…”
Section: Cell-derived Biomaterials For Inflammationmentioning
confidence: 99%
“…Additionally, exosomes can be synthetically supplemented to enhance cellular targeting and therapeutic efficacy. 33 , 34 , 35 For example, anti-inflammatory peptides 36 can be linked onto the exosomal membrane, engineering an immune cell targeting nanomedicine. The combination of vesicle derivation and supplementation allows for a customizable nanoparticle delivery platform that can be utilized across many lung diseases.…”
Section: Introductionmentioning
confidence: 99%