Advanced nanofibrous textile-based dressing material for treating chronic wounds

Abstract

In the present work, an electrospun nanofibrous textile composed of polyurethane (PU), sodium bicarbonate (NaHCO 3) and pantothenic acid (PA) is developed for treating chronic wounds. Wounds are a common health problem and in particular, the chronic wounds such as vascular ulcers, diabetic ulcers and pressure ulcers cause a large number of morbidity and mortality. The main problems of the chronic wounds are prolonged inflammation phase and presence of acidic environment. These events deactivate the operation of growth factors and also the progression of natural healing mechanism. Hence, various types of advanced textile-based dressings are developed to address the clinical complications associated with chronic wound management. The prepared electrospun scaffolds were characterized to study their physicochemical and haemocompatible properties. The scanning electron microscopy micrographs depicted continuous, smooth-interconnected nanofibrous morphology of PU-NaHCO 3-PA scaffolds. The Fourier transform infrared spectroscopy spectra indicated the addition of NaHCO 3 and PA-based hydrophilic chemical groups, which significantly enhanced the wettability of the composites. Further, the PU-NaHCO 3-PA composite membrane inferred to have a highly porous structure with the mean porosity of 79.4 ± 4.8%, which may provide a conducive environment for adherence and proliferation of skin cells. The composite scaffold also offers a highly haemocompatible surface by delaying coagulation of blood through contact activation pathways and by limiting red blood cells damage. Therefore, the excellent physicochemical properties, blood compatibility and the delivery of PA are anticipated to speed up the impaired healing process of chronic wounds.

Cotton‐hydrogel composite for improved wound healing: Antimicrobial activity and anti‐inflammatory evaluation—Part 2

“…The cotton still is a standard dressing for wound management, since it offers mechanical support and gas and water permeability . Cellulose, as the main component of cotton, is nontoxic, homeostatic, nonallergic, and biocompatible . Cyclodextrins are biocompatibility cyclic oligosaccharides and approved by FDA .…”

“…An analysis of variance (ANOVA) was carried out to determine any significant differences between the standard conditions and the new adaptations. 22 Cyclodextrins are biocompatibility cyclic oligosaccharides and approved by FDA. 23 They are able to protect and modulate the release of a wide range of molecules.…”

Chelidoniummajus L. Incorporated Emulsion Electrospun PCL/PVA_PEC Nanofibrous Meshes for Antibacterial Wound Dressing Applications

“…The electrospun nanofibrous meshes exhibit desirable features for wound healing occurs, once they form randomly orientated 3D-structures which resemble the skin’s extracellular matrix (ECM) [ 4 , 6 , 8 , 9 , 10 , 11 ]. Moreover, these meshes display high surface area, high porosity, and interconnected pores, which provide a suitable microenvironment for cell attachment, growth, and differentiation, as well as angiogenesis and collagen synthesis [ 3 , 4 , 6 , 8 , 9 , 12 , 13 , 14 ]. Furthermore, the electrospun nanofibers can control gas exchanges, supply water and nutrients to the wound site, and assist in fluids absorption, maintaining a moisture balance at the wound dressing interface [ 4 , 6 , 13 ].…”

“…Furthermore, the electrospun nanofibers can control gas exchanges, supply water and nutrients to the wound site, and assist in fluids absorption, maintaining a moisture balance at the wound dressing interface [ 4 , 6 , 13 ]. These materials also exhibit potential to scar-free repair and regeneration, and the loading ability for a wide variety of bioactive or therapeutic agents, including antimicrobials, anti-inflammatories, growth factors, vitamins, and even cells [ 4 , 6 , 8 , 9 , 12 , 13 , 14 , 15 , 16 ].…”

Phospholipid multilamellar vesicles entrapping phenothiazine photosensitizers. Preparation, characterization and evaluation of their photodynamic properties

“…[5,6] There are different drug delivery approaches that can be used for the diagnosis and treatment of numerous diseases Examples of the main nanocarriers used in the field of medicine include micelles, liposomes, dendrimers, carbon nanotubes, nanoshells, and gold, silver and copper nanoparticles. [7][8][9][10][11][12][13][14][15] Liposomes are currently one of the most commonly used drug nanocarrier systems in clinical applications and are particularly employed in the treatment of various oncological diseases. [16] These strategies are widely investigated for their use in PDT and APDT because they are versatile systems capable of encapsulating hydrophilic, hydrophobic, and amphiphilic molecules.…”