Advanced nanomaterial for point-of-care chemotherapy

Panda, Sucheta; Das, Harish Chandra; Panda, Sudhakar; Kolluri, Spoorthy; Kilaru, Sindhu

doi:10.1016/b978-0-323-85725-3.00006-4

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…Thus, surface modification is required to prevent agglomeration and enable surface functionalization tailored to specific applications. [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of nanomaterials on autophagy across health and disease conditions

Florance,

Cordani,

Pashootan

et al. 2024

Cell. Mol. Life Sci.

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Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity. Graphical Abstract

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“…Thus, surface modification is required to prevent agglomeration and enable surface functionalization tailored to specific applications. [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of nanomaterials on autophagy across health and disease conditions

Florance,

Cordani,

Pashootan

et al. 2024

Cell. Mol. Life Sci.

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The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy

Golshirazi,

Mohammadzadeh,

Labbaf

2024

Macromolecular Bioscience

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The stratum corneum, which acts as a strong barrier against external agents, presents a significant challenge to transdermal drug delivery. In this regard, microneedle (MN) patches, designed as modern systems for drug delivery via permeation through the skin with the ability to pass through the stratum corneum, are known to be convenient, painless, and effective. In fact, MN have shown significant breakthroughs in transdermal drug delivery, and among the various types, hydrogel MN (HMNs) have demonstrated desirable inherent properties. Despite advancements, issues such as limited loading capacity, uncontrolled drug release rates, and non‐uniform therapeutic approaches persist. Conversely, nanomaterials (NMs) have shown significant promise in medical applications, however, their efficacy and applicability are constrained by challenges including poor stability, low bioavailability, limited payload capacity, and rapid clearance by the immune system. Incorporation of NMs within HMNs offers new prospects to address the challenges associated with HMNs and NMs. This combination can provide a promising field of research for improved and effective delivery of therapeutic agents and mitigate certain adverse effects, addressing current clinical concerns. The current review highlights the use of NMs in HMNs for various therapeutic and diagnostic applications.

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Advanced nanomaterial for point-of-care chemotherapy

Cited by 2 publications

References 83 publications

The impact of nanomaterials on autophagy across health and disease conditions

The impact of nanomaterials on autophagy across health and disease conditions

The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy

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