Advanced nanomedicine for rheumatoid arthritis treatment: focus on active targeting

Chen, Minglei; J.C., Kambere Amerigos Daddy; Xiao, Yanyu; Ping, Qineng; Zong, Li

doi:10.1080/17425247.2017.1372746

Cited by 56 publications

(27 citation statements)

References 16 publications

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“…Besides, peptides are often combined with other ligands to enhance macrophage phagocytosis. (Conde et al, 2015;Qian et al, 2017;Scodeller et al, 2017;Cheng et al, 2018) system, vascular endothelium, and specifically suitable ligands attached to the nanoplatforms (Chen et al, 2017). In the following sections, we will discuss several representative active macrophage targeting strategies.…”

Section: Dectin-1mentioning

confidence: 99%

Role of macrophage in nanomedicine-based disease treatment

et al. 2021

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Macrophages are a major component of the immunoresponse. Diversity and plasticity are two of the hallmarks of macrophages, which allow them to act as proinflammatory, anti-inflammatory, and homeostatic agents. Research has found that cancer and many inflammatory or autoimmune disorders are correlated with activation and tissue infiltration of macrophages. Recent developments in macrophage nanomedicine-based disease treatment are proving to be timely owing to the increasing inadequacy of traditional treatment. Here, we review the role of macrophages in nanomedicine-based disease treatment. First, we present a brief background on macrophages and nanomedicine. Then, we delve into applications of macrophages as a target for disease treatment and delivery systems and summarize the applications of macrophage-derived extracellular vesicles. Finally, we provide an outlook on the clinical utility of macrophages in nanomedicine-based disease treatment.

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Section: Dectin-1mentioning

confidence: 99%

Role of macrophage in nanomedicine-based disease treatment

et al. 2021

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“…Rheumatoid arthritis (RA) is another disease that has seen the development of NP-based systems for targeted drug delivery at the cellular level [97,98,99,100]. RA is a chronic inflammatory disease with a complex pathology characterized by inflammation of the joints, destruction of the synovium, production of autoantibodies, and damage of bone and cartilage.…”

Section: Active Cellular Targeting Of Nanoparticle (Np)-drug Systemsmentioning

confidence: 99%

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Nag

Delehanty

2019

Pharmaceutics

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Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of traditional drug delivery approaches, including off-target drug toxicity and the need for the administration of repetitive doses. In the last decade, one of the main foci in NMDD has been the realization of NP-mediated drug formulations for active targeted delivery to diseased tissues, with an emphasis on cellular and subcellular targeting. Advances on this front have included the intricate design of targeted NP-drug constructs to navigate through biological barriers, overcome multidrug resistance (MDR), decrease side effects, and improve overall drug efficacy. In this review, we survey advancements in NP-mediated drug targeting over the last five years, highlighting how various NP-drug constructs have been designed to achieve active targeted delivery and improved therapeutic outcomes for critical diseases including cancer, rheumatoid arthritis, and Alzheimer’s disease. We conclude with a survey of the current clinical trial landscape for active targeted NP-drug delivery and how we envision this field will progress in the near future.

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“…The leaky vasculature of the inflamed joints allows using the EPR effect (passive targeting). Nonetheless, active targeting has been taking advantage of the influx of various inflammatory cells including macrophages, fibroblast-like synoviocytes (FLS), and lymphocytes into the synovial space [72]. Many receptors are upregulated on the activated macrophages, such as the folate receptor β and the scavenger receptor.…”

Section: Inflammation Targetingmentioning

confidence: 99%

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Lima

Ferreira

Reis

et al. 2019

Expert Opinion on Drug Delivery

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Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.

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Advanced nanomedicine for rheumatoid arthritis treatment: focus on active targeting

Cited by 56 publications

References 16 publications

Role of macrophage in nanomedicine-based disease treatment

Role of macrophage in nanomedicine-based disease treatment

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

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