Advanced neuroimaging of migraine

Schwedt, Todd J.; Dodick, David W.

doi:10.1016/s1474-4422(09)70107-3

Cited by 153 publications

(167 citation statements)

References 75 publications

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“…These studies have shown a widespread subcortical and cortical brain network involved in pain processing in migraine subjects. However, one of the main challenges in the interpretation of these results is to differentiate findings consistent with a general pain response from those that might be specific to migraine [11,12]. Nevertheless, a noxious stimulation paradigm, using a contact thermode [26], has been extensively used in different BOLD-fMRI studies to elucidate mechanisms underlying pain processing in migraine subjects.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, in event-related experiments BOLDfMRI response is modeled as the linear summation of the hemodynamic response to discrete events [10]. It is well known that migraine episodes are typically unpredictable while BOLD-fMRI studies require considerable planning and this justify the scarcity of fMRI data during spontaneous attacks of migraine [11]. In consequence, BOLDfMRI research field has been dominated by event-related experiments, specifically triggered migraine attack or experimental acute-pain studies, during interictal period.…”

Section: Introductionmentioning

confidence: 99%

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The role of BOLD-fMRI in elucidating migraine pathophysiology

et al. 2013

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Migraine is a neurologic disorder characterized by disabling attacks of throbbing headache with specific features and associated symptoms. Despite the recent discoveries in basic neurosciences, migraine pathophysiology is not completely understood. Nevertheless, in the last decades, advances in functional magnetic resonance imaging (fMRI) have significantly provided new insights into migraine mechanisms. Blood oxygen level dependent (BOLD) fMRI technique is the most commonly used method to explore brain function and connectivity due to high temporal and spatial resolution. The purpose of this review is to present a synthesis of recent BOLD-fMRI studies which have allowed us to elucidate the complex process involved in migraine pathophysiology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of BOLD-fMRI in elucidating migraine pathophysiology

et al. 2013

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“…23,24 Previous theories have focused on vascular causes and extracranial vasodilation being responsible in causing the migraine attacks. 25,26 Now migraine can no longer be considered a vascular or a neurovascular disorder, but instead should be thought of as a disease mediated by the central nervous system. 26 Current theories on migraine argue that the trigeminal nerve that innervates the meninges affects pain-sensitive vascular structures in the dura mater, base of skull, and scalp that are involved in the migraine attack.…”

Section: Discussionmentioning

confidence: 99%

Chiropractic spinal manipulative treatment of migraine headache of 40-year duration using Gonstead method: a case study

Chaibi¹,

Tuchin

2011

Journal of Chiropractic Medicine

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Objective: The purpose of this article is to present a case study of chiropractic spinal manipulative treatment (CSMT) using the Gonstead method for a patient with migraines. Clinical Features: The patient was a 52-year-old married woman with a long-term history of chronic migraines, which included nausea, vomiting, and photophobia. The patient had endometriosis, but did not relate the migraines to her menstrual cycles. She also reported not using medication for her migraines due to previous drug-related issues. The average frequency of episodes before treatment was 1 per month, and her migraines often included an aura. The pain was moderate, was located on the right side, was pulsating, and lasted for approximately 15 hours. The numeric pain scale for an average episode was 8 out of a possible 10. The aura involved nausea, photophobia, and visual disturbances including black dots in the visual field lasting for approximately 10 minutes. Intervention and Outcome: The patient reported all episodes being eliminated following CSMT. At 6-month follow-up, the patient had not had a single migraine episode in this period. The patient was certain that there had been no other lifestyle changes that could have contributed to her improvement. Conclusion: This case adds to previous research suggesting that some migraine patients may respond favorably to CSMT. The case also provides information on the Gonstead method. A case study does not represent significant scientific evidence in context with other studies conducted; this study suggests that a trial of CSMT using the Gonstead methods could be considered for chronic, nonresponsive migraines.

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“…This finding offers an important clue for the mechanism of migraine and may indicate a potential therapeutic option; namely, the possibility that sodium depletion is involved with migraine onset and persistence. The anatomy of migraine is now visible in scanners [10][11][12][13][14]. Depolarized regions, zones of cortical depression (CD), are unable to generate energy for action potential [16].…”

Section: Introductionmentioning

confidence: 99%

Migraine Cause And Treatment

Stanton¹

2015

Ment Health Fam Med

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Background:Research shows that migraine brains have hyperactive sensory organs and multiple sensory receptor connections. Hyper activity of these organs needs extra supply of nutrition to support increased electrical activity. Today's medicines reduce or prevent the functioning of these neurons by blocking essential voltage dependent calcium or sodium channel instead of providing nutrients. We asked: if we provide support for extra electrical activity of migraineurs, would it prevent migraines without the use of medicines? Methods:We reviewed published literature and conducted research over 6 months studying 650 volunteer migraineurs in a migraine-research Facebook group. Participants were screened for migraine types, answered a questionnaire on medical conditions, medicines used, and lifestyle. They were provided instructions on the use of the migraine protocol and were evaluated weekly. Findings:Migraine frequency appears to be exacerbated by carbohydrate-rich and salt-and water-poor diets and may be worsened by medicines that block voltage gated calcium or sodium channels. Stopping these medicines, reducing carbohydrates and increasing saline in electrolytes appears to prevent and/or stop migraines.Conclusions: H 2 O and Na+ efflux from cells caused by glucose, electrolyte mineral (Na+, Cl-, K+) ratio may be disrupted in carbohydrate heavy diets causing migraines. Changes to diet that include increased salt intake along with reduced carbohydrate intake appears to prevent glucose induced electrolyte changes which then decreases migraine frequency. In the present study, all participants who made these dietary changes were able to eliminate migraine medications and remained migraine free.

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Advanced neuroimaging of migraine

Cited by 153 publications

References 75 publications

The role of BOLD-fMRI in elucidating migraine pathophysiology

The role of BOLD-fMRI in elucidating migraine pathophysiology

Chiropractic spinal manipulative treatment of migraine headache of 40-year duration using Gonstead method: a case study

Migraine Cause And Treatment

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