Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea

Erdoğan, Hilal Kaya; Bulur, İşıl; Kocatürk, Evin; Saraçoğlu, Zeynep Nurhan; Alataş, Özkaņ; Bilgin, Muzaffer

doi:10.5114/ada.2018.76228

Cited by 21 publications

(25 citation statements)

References 12 publications

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“…Previous studies showed that ROS activity in biopsy samples taken from individuals with rosacea was found to be higher in rosacea lesion skin 16,17 . In a recent study, serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and advanced oxidation protein products (AOPP) in rosacea patients were compared with the HCs, and while no differences were found between two groups in terms of OSI levels, TOS, TAS, and AOPP levels were reported to be significantly higher in patient group 18 . In our study, statistically significantly low serum bilirubin and UA levels of rosacea patients when compared with the HC group sustain the view that oxidative stress‐antioxidant balance changes in favor of oxidative stress in rosacea disease and in turn may cause inflammation.…”

Section: Discussionsupporting

confidence: 93%

Serum bilirubin and uric acid antioxidant levels in rosacea patients

Türkmen

2020

J of Cosmetic Dermatology

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Background Rosacea is a common chronic inflammatory skin disease that the pathogenesis is not fully understood. Although the significant role of oxidative stress in rosacea pathophysiology has been shown in recent studies, there is no study addressing the potential roles of bilirubin and uric acid (UA) in rosacea. Aim The purpose of this study was to assign serum bilirubin and UA antioxidant levels in rosacea patients. Methods Eighty‐seven rosacea patients and 81 healthy controls (HCs) similar age and gender were included in the study. From all study participants, blood samples were taken and the values of total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), and UA were analyzed in the laboratory of biochemistry. Results The type of rosacea was erythematotelangiectatic in 51.7% of the patients, papulopustular in 43.7%, and phymatous in 4.6%. In rosacea group serum, Tbil, Dbil, Ibil, and UA values were found to be significantly lower than in the HCs. Male rosacea patients were found to have lower Tbil, Dbil, Ibil, and UA levels when compared with the males in the HCs. There was also the same significant difference in female patients. Conclusion Main finding of our study was that when compared with the control group, serum bilirubin and UA levels were significantly lower in rosacea patients. These levels sustain the hypothesis that antioxidant status and oxidative stress are important in the pathogenesis of rosacea.

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Section: Discussionsupporting

confidence: 93%

Serum bilirubin and uric acid antioxidant levels in rosacea patients

Türkmen

2020

J of Cosmetic Dermatology

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“…Derangements in the oxidant/antioxidant system have been identified in rosacea 4,5,9 . Erdogan et al 24 interpreted the oxidant stress condition by assessing serum total oxidant/antioxidant status, advanced oxidation protein products, and oxidant stress index in rosacea patients and found significantly elevated levels of each, supporting the notion of oxidant stress acting in the pathogenesis of rosacea. More recently, Sener et al 25 investigated thiol/disulfide homeostasis (which has important roles in the antioxidative process) in patients with rosacea.…”

Section: Discussionmentioning

confidence: 96%

Expressions of glutathione S‐transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea

Takçı

Bilgili

Kilic

et al. 2020

J of Cosmetic Dermatology

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Background Data point to the importance of oxidative stress in rosacea. Glutathione S‐transferases (GSTs) have substantial roles in a wide variety of oxidative stress‐related conditions. Aim To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and theta (GSTT) in patients with rosacea. Patients/Methods The study included 23 women and 7 men with rosacea (mean ± SD age 49 ± 11 year) and 15 healthy control subjects (10 women, 5 men; mean ± SD age 47.86 ± 10.88 year). For each patient, the average disease duration, disease subtype, ocular involvement, and severity score were recorded. A 3‐mm punch biopsy was taken from the facial skin of each patient and control. Expression of GST isoenzymes was analyzed immunohistochemically. Results Expressions of GSTM1, GSTP1, and GSTT1 were significantly elevated in patients with rosacea compared to those in the control group (P = .0001, P = .0002, P < .0001, respectively). In the rosacea group, GSTT1 expression was significantly stronger than GSTP1 and GSTA1 expressions (P = .019, P < .0001, respectively). There were no significant associations between expressions of GST isoenzymes and gender, age, average duration of illness, disease subtype, ocular involvement, or severity score in the patient group (all P > .05). Conclusions In rosacea, the significant increase of GSTT1, GSTP1, and GSTM1 expressions might result from activation of GST as an outcome of extreme free radical generation from triggered neutrophils or ultraviolet vulnerability. These findings support the relevance of oxidant stress in the pathogenesis of rosacea.

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“…The contribution of antioxidant system in patients with rosacea has likewise been shown at the genetic level. 47 In particular, the Glutathione-S-transferase (GST)M1 and GSTT1 genes which encode for enzymes neutralizing toxic oxidative intermediates, were found to have null mutations in a high proportion of patients with rosacea. 48…”

Section: Genetic Factorsmentioning

confidence: 99%

Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review

Jabbehdari

Memar

Caughlin

et al. 2020

European Journal of Ophthalmology

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Purpose: Rosacea is one of the most common conditions affecting the ocular surface. The purpose of this review is to provide an update on the pathogenesis and treatment of rosacea based on the dermatology and ophthalmology literatures. Methods: Literature searches were conducted for rosacea and ocular rosacea. Preference was given to systematic reviews, meta-analysis, case-controlled studies, and documented case reports while excluding poorly documented case studies and commentaries. The data were examined and independently analyzed by more than two of the authors. Results: Rosacea is a complex inflammatory condition involving the pilosebaceous unit. Its underlying mechanism involves an interplay of the microbiome, innate immunity, adaptive immunity, environmental triggers, and neurovascular sensitivity. The latest classification of rosacea includes three dermatologic subgroups and a fourth subgroup, ocular rosacea. Ocular rosacea clinically displays many features that are analogous to the cutaneous disease, such as lid margin telangiectasia and phlyctenulosis. The role of environmental triggers in the exacerbation of ocular rosacea appears to be understudied. While lid hygiene and systemic treatment with tetracycline drugs remain the mainstay of treatment for ocular rosacea, newer dermatologic targets and therapies may have potential application for the eye disease. Conclusions: Ocular rosacea appears to embody many of the manifestation of the dermatologic disease. Hence, the basic pathophysiologic mechanisms of the ocular and cutaneous disease are likely to be shared. Better understanding of the ocular surface microbiome and the immunologic mechanisms, may lead to novel approaches in the management of ocular rosacea.

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Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea

Cited by 21 publications

References 12 publications

Serum bilirubin and uric acid antioxidant levels in rosacea patients

Serum bilirubin and uric acid antioxidant levels in rosacea patients

Expressions of glutathione S‐transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea

Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review

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