Advanced oxidation protein products are more related to metabolic syndrome components than biomarkers of lipid peroxidation

Venturini, Danielle; Simão, Andréa Name Colado; Dichi, Isaías

doi:10.1016/j.nutres.2015.06.013

Cited by 27 publications

(35 citation statements)

References 35 publications

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“…AOPPs are structurally similar to advanced glycation end products (AGEs) and exert similar biological activities to those of AGEs -i.e., induction of pro-inflammatory cytokines and adhesion molecules (11). The present study showing that AOPPs were associated with metabolic changes and hypertension is in line with the importance of protein oxidation in patients with these components of MetS, independent of BMI, and confirm our previous finding that protein oxidation is more related to MetS parameters than lipid oxidation (30). Of note, BMI does not participate in the definition of the MetS and does not have a robust association verified between WC and insulin resistance.…”

Section: Discussionsupporting

confidence: 92%

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Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Morelli¹,

Scavuzzi²,

Miglioranza³

et al. 2018

Archives of Endocrinology and Metabolism

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Section: Discussionsupporting

confidence: 92%

“…Of note, BMI does not participate in the definition of the MetS and does not have a robust association verified between WC and insulin resistance. Although some studies have reported an association between AOPPs and BMI (13,30), the current study only presented this finding when the groups were not adjusted for the presence of MetS.…”

Section: Discussionmentioning

confidence: 57%

Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Morelli¹,

Scavuzzi²,

Miglioranza³

et al. 2018

Archives of Endocrinology and Metabolism

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“…AOPPs, differently from MDA, were significantly related to the number of components of MS in omnivore subjects, even though the relation was significant for both parameters in vegetarians [87]. In a more recent research, AOPPs were significantly related to the number of metabolic syndrome components, whereas lipid hydroperoxides did not show any correlation [13]. Our study indicates a possible link between protein oxidation and gelatinases in adult obese patients.…”

Section: Obese Subjectscontrasting

confidence: 53%

“…Elevated levels of adipokines and oxidative stress markers, such as HNE-protein adducts and ROS, were observed in obese subjects, accompanied by a parallel reduction of plasma antioxidants [12]. Obese subjects with metabolic syndrome (MS) had elevated levels of hydroperoxides and AOPPs and lower antioxidants [13]. In obese subjects body mass index (BMI) showed a positive correlation with PCs [14]; waist circumference (WC) was directly correlated with hydroperoxide levels [15] and lipid peroxidation [16].…”

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity

et al. 2019

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The association between obesity and cardiovascular diseases has a multifactorial pathogenesis, including the synthesis of inflammatory molecules, the increase in oxidative stress and the dysregulation of the matrix metalloprotease (MMP) concentration and activity. In a group of adults with obesity, divided in 2 subgroups according to the body mass index (BMI), we examined lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), protein oxidation, expressed as protein carbonyl groups (PCs), plasma gelatinases (MMP-2 and MMP-9), and their tissue inhibitors (TIMP-1 and TIMP-2). In the whole group, as well as in the 2 subgroups (with BMI 30–35 or BMI>35) of obese subjects, we observed an increase in TBARS, PCs, MMP-2, and MMP-9, and also TIMP-1 and TIMP-2 in comparison with the control group. A positive correlation between TBARS and PCs emerged in obese subjects and persisted after dividing obese subjects according to BMI. The correlation between MMP-2 and TIMP-2 was not statistically significant, while a significant correlation was present between MMP-9 and TIMP-1. The correlations between the markers of oxidative stress (TBARS and PCs) and those of the MMP/TIMP profile indicated a more marked influence of protein oxidation on MMPs and TIMPs in comparison with TBARS. The innovative aspect of our study was the simultaneous evaluation of oxidative stress markers and MMP/TIMP profile in adult obese subjects. We observed significant alterations and correlations that may negatively influence the clinical course of the disease.

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“…This is a sensitive and accurate method, with good stability to light/oxygen and with high reproducibility (Gay & Gebicki, ; Mehta, Darji, & Aparnathi, ; Orefice et al., ; Yu, Wang, Zhou, Zhao, & Qiu, ). The FOX method can be employed for determining H 2 O 2 (Nourooz‐Zadeh, ; Sturza et al., ; Yu et al., ), lipid (Ceylan et al., ; Gay & Gebicki, ; Nourooz‐Zadeh, ; Venturini, Simao, & Dichi, ), and protein (Gay & Gebicki, ) hydroperoxides in a wide range of biological samples, from serum (Takci et al., ) and lipoproteins (Erel, ) to cerebrospinal fluid, urine (Erel, ), and tissue homogenates (de Andrade et al., ).…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric versus spectrofluorometric assessment in the study of the relationships between lipid peroxidation and metabolic dysregulation

et al. 2019

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Reactive oxygen species are crucial to normal cell function, but are also part of the pathogenesis of multiple modern maladies. As such, sensitive, fast, and reliable methods of appreciating redox status are needed. We aimed to optimize the Amplex Red (AR) and ferric–xylenol orange (FOX) methods using human serum samples, rat tissue homogenates, and mitochondrial preparations. For AR, we intended to reduce probe concentration, maintaining method sensitivity, as well as extending its use from isolated lipoproteins samples, and readjust it for a high‐throughput application. Also, we evaluated the usefulness of a modified xylenol orange‐based spectrophotometric protocol, comparing and contrasting these methods in terms of clinical relevance and suitability for their further use in assessing redox status of various biological samples in different pathological conditions. Our results show that these optimized protocols are suitable for complex in vivo studies, as they require low quantities of sample and reagents, and are sensitive, rapid, and economical, with the option of adapting them for high‐throughput analysis. For a better assessment of oxidative status of serum‐derived samples, the two methods can be used concurrently, while for tissue‐derived ones, either can be employed for the measurement of a global redox status.

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Advanced oxidation protein products are more related to metabolic syndrome components than biomarkers of lipid peroxidation

Cited by 27 publications

References 35 publications

Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Metabolic syndrome components are associated with oxidative stress in overweight and obese patients

Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity

Spectrophotometric versus spectrofluorometric assessment in the study of the relationships between lipid peroxidation and metabolic dysregulation

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