Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: A possible link between oxidative stress and preeclampsia

Huang, Qiaobing; Wang, S.S.; Zhang, M.; Huang, Liping; Tian, Jing; Yu, Yinhua; Wang, Z.J.; Zhong, Ming

doi:10.1016/j.placenta.2013.06.308

Cited by 43 publications

(26 citation statements)

References 32 publications

(34 reference statements)

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“…This finding is in contrast to an earlier study which showed that the levels of AOPP did not change significantly among the control, pre-eclampsia and eclampsia groups [26]. AOPP's are important mediators in the regulation and signaling of angiogenic pathways of trophoblasts, enhancing soluble Fms-like tyrosine kinase 1 expression in trophoblasts, promoting the development of preeclampsia [27]. Whether AOPP mediates similar signaling pathways as an attributable mechanism for development of other different hypertensive disorders is yet to be explored.…”

Section: Discussioncontrasting

confidence: 99%

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

et al. 2016

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Protein oxidation has been demonstrated in preeclampsia, but this finding has not been established in other hypertensive disorders in pregnancy (HDP). The present study comparatively evaluated ischemia modified albumin (IMA) and advanced oxidation protein products (AOPP) in different HDP and investigated their association with total antioxidant activity (AOA) and total thiols. There was a significant increase in AOPP and IMA, a significant decrease in AOA, total thiols and albumin in every HDP compared to controls. Among HDP groups, eclampsia patients showed more significant change in each of the parameter. IMA and AOPP were negatively associated with AOA in every HDP and with total thiols only in eclampsia. The present study supports the hypothesis of oxidative stress, as evidenced by increased protein oxidation, decreased antioxidant status and significant negative association between protein oxidation and AOA in every HDP. The imbalance of prooxidants and antioxidants was further augmented in eclampsia.

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Section: Discussioncontrasting

confidence: 99%

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

et al. 2016

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“…These effects are able to be inhibited by a combination of apocynin and NOX inhibitors. Therefore, accumulation of AOPPs might contribute to the pathogenesis of preeclampsia by promoting sFlt-1 production in trophoblasts [ 72 ].…”

Section: Cellular Sources Of Oxidative Stress In the Human Placentmentioning

confidence: 99%

Oxidative Stress in Preeclampsia and Placental Diseases

Aouache

Biquard

Vaiman

et al. 2018

IJMS

430

259

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Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.

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“…Implicit in this generalized endothelial dysfunction may be an imbalance of angiogenic and anti-angiogenic factors ( 26 – 28 ). Both circulating and placental levels of soluble fms-like tyrosine kinase-1 (sFlt-1) are higher in women with preeclampsia than in women with normal pregnancy ( 29 – 31 ). sFlt-1 is an anti-angiogenic protein that antagonizes vascular endothelial growth factor (VEGF) and PIGF ( 32 – 34 ), both of which are pro-angiogenic factors.…”

Section: Discussionmentioning

confidence: 99%

Serum biomarkers combined with uterine artery Doppler in prediction of preeclampsia

Zheng

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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First-trimester screening may be a major advantage over a second-trimester approach since it opens prospects for early and more efficient interventions. The aim of the current study was to evaluate whether the measurement of maternal serum inhibin A, activin A and placental growth factor (PlGF) at three to four months gestation with the second-trimester uterine artery pulsatility index (PI) are useful in predicting preeclampsia in a group of nulliparous women. All the patients also underwent uterine artery Doppler examination to measure the PI at 22–24 weeks gestation. Inhibin A, activin A and PlGF were measured using an ELISA by an examiner who was blinded to the pregnancy outcome. Thirty-eight cases with preeclampsia and 100 controls were analyzed. Second-trimester uterine artery PI and marker levels were expressed as multiples of the median (MoM). The uterine artery PI was increased in pregnancies with preeclampsia compared with controls. In pregnancies that developed preeclampsia, the uterine artery PI was increased (1.61±0.047 vs. 1.02±0.049, P<0.001), as was the level of inhibin A (1.72±0.023 vs. 1.03±0.063, P<0.001) and the level of activin A (1.68±0.38 vs. 1.06±0.42, P<0.001) compared with the controls. In contrast, the level of PlGF was decreased in pregnancies that developed preeclampsia compared with the controls (0.69±0.23 vs. 1.00±0.26, P<0.001). A combination of activin A, PlGF and uterine artery PI gave an AUC of 0.915 (95% CI, 0.812–0.928; P<0.001) with a sensitivity of 91% at a specificity of 82%. In our study, we demonstrated that both serum inhibin A and activin A levels were increased, while the PlGF level was decreased in the early second-trimester in women who developed preeclampsia.

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Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: A possible link between oxidative stress and preeclampsia

Cited by 43 publications

References 32 publications

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

Increased Oxidatively Modified Forms of Albumin in Association with Decreased Total Antioxidant Activity in Different Types of Hypertensive Disorders of Pregnancy

Oxidative Stress in Preeclampsia and Placental Diseases

Serum biomarkers combined with uterine artery Doppler in prediction of preeclampsia

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