Advanced parental age and risk of positive autism spectrum disorders screening

Manzouri, Leila; Yousefian, Sepideh; Keshtkari, A; Hashemi, Nazir

doi:10.4103/ijpvm.ijpvm_25_19

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…In contrast to our study, many studies confirmed the strong correlation between the increased risk of having ASD in the children and the age of the parent [24,38] or the age of mothers [50] or the increase in the order of the childbirth.…”

Section: Regarding the Age Of Parentscontrasting

confidence: 99%

Autistic traits in offspring of schizophrenic patients in comparison to those of normal population: a case-control study

Amin

El-deen

2021

Middle East Curr Psychiatry

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Background Autism is not a discreet condition and those families members with autistic propend are more likely to display autistic symptoms with a wide range of severity, even below the threshold for diagnosis of autism spectrum disorders. Even with a parental history of schizophrenia, the likelihood of autistic spectrum disorder was found to be 3-fold greater. The aim of this study is to assess autistic traits among offspring of schizophrenic patients in the age group from 4 to 11 years and compare it in the offspring of normal individuals, and its association with the sociodemographic data. To determine whether schizophrenic parents are a risk factor to autistic traits in their children. Results There was a statistically significant (P < 0.05*) increase in Autism Quotient Child scores of the case group where 47.2% had a score equal or more than the cutoff point (76), while only 17 19.4% of the control group had the same score with odds = 3.71 indicating that children of schizophrenic parents 18 were three times likely to have Autism Quotient-Child score greater than or equal to the cutoff point (76) than 19 children of healthy parents. No statistically significant association (P ≥ 0.05) was found between all 20 sociodemographic characteristics and Autism Quotient-Child scores among the case group except for family 21 income and social class where there was a statistically significant association (P < 0.05) between insufficient income 22 and low social class and higher Autism Quotient-Child score (≥ 76). Conclusions Children of schizophrenic parents are at high risk to have autistic traits than children of normal parents.

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Section: Regarding the Age Of Parentscontrasting

confidence: 99%

Autistic traits in offspring of schizophrenic patients in comparison to those of normal population: a case-control study

Amin

El-deen

2021

Middle East Curr Psychiatry

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“… Ben Itzchak et al (2011) , Durkin et al (2008) , Hultman et al (2011) , King et al (2009) , Lampi et al (2013) , Lung et al (2018) , Manzouri et al (2019) , Merikangas et al (2017) , Reichenberg et al (2006) , Rieske and Matson (2020) , Shelton and Tancredi (2010) , Shimada et al (2012) , Taylor et al (2019) , Tsuchiya et al (2008) , and Van Balkom et al (2012) …”

Section: Resultsmentioning

confidence: 99%

Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring

Neeser,

Martani,

De Clercq

et al. 2023

Human Reproduction Open

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STUDY QUESTION What is the existing empirical literature on the psychosocial health and wellbeing of the parents and offspring born at an advanced parental age (APA), defined as 40 years onwards? SUMMARY ANSWER Although the studies show discrepancies in defining who is an APA parent and an imbalance in the empirical evidence for offspring, mothers and fathers, there is a drive towards finding psychotic disorders and (neuro-)developmental disorders among the offspring; overall the observed advantages and disadvantages are difficult to compare. WHAT IS KNOWN ALREADY In many societies, children are born to parents at advanced ages and there is rising attention in the literature towards the consequences of this trend. STUDY DESIGN, SIZE, DURATION The systematic search was conducted in six electronic databases (Pubmed including MEDLINE, Embase, Scopus, PsycInfo, CINAHL and SocINDEX), and was limited to papers published between 2000 and 2021 and to English-language articles. Search terms used across all six electronic databases were: (‘advanced parental age’ OR ‘advanced maternal age’ OR ‘advanced paternal age’ OR ‘advanced reproductive age’ OR ‘late parent*’ OR ‘late motherhood’ OR ‘late fatherhood’) AND (‘IVF’ OR ‘in vitro fertilization’ OR ‘in-vitro-fertilization’ OR ‘fertilization in vitro’ OR ‘ICSI’ OR ‘intracytoplasmic sperm injection’ OR ‘reproductive techn*’ OR ‘assisted reproductive technolog*’ OR ‘assisted reproduction’ OR ‘assisted conception’ OR ‘reproduction’ OR ‘conception’ OR ‘birth*’ OR ‘pregnan*’) AND (‘wellbeing’ OR ‘well-being’ OR ‘psycho-social’ OR ‘social’ OR ‘ethical’ OR ‘right to reproduce’ OR ‘justice’ OR ‘family functioning’ OR ‘parental competenc*’ OR ‘ageism’ OR ‘reproductive autonomy’ OR ‘outcome’ OR ‘risk*’ OR ‘benefit*’). PARTICIPANTS/MATERIALS, SETTING, METHODS The included papers were empirical studies in English published between 2000 and 2021, where the study either examined the wellbeing and psychosocial health of parents and/or their children, or focused on parental competences of APA parents or on the functioning of families with APA parents. A quality assessment of the identified studies was performed with the QATSDD tool. Additionally, 20% of studies were double-checked at the data extraction and quality assessment stage to avoid bias. The variables sought were: the geographical location, the year of publication, the methodological approach, the definitions of APA used, what study group was at the center of the research, what research topic was studied, and what advantages and disadvantages of APA were found. MAIN RESULTS AND THE ROLE OF CHANCE A total number of 5403 articles were identified, leading to 2543 articles being included for title and abstract screening after removal of duplicates. This resulted in 98 articles included for a full-text reading by four researchers. Ultimately, 69 studies were included in the final sample. The key results concerned four aspects relevant to the research goals. (1) The studies showed discrepancies in defining who is an APA parent. (2) There was an imbalance in the empirical evidence produced for different participant groups (mothers, fathers and offspring), with offspring being the most studied study subjects. (3) The research topics studied underlined the increased risks of neuro-developmental and psychotic disorders among offspring. (4) The observed advantages and disadvantages were varied and could not be compared, especially for the offspring of APA parents. LIMITATIONS, REASONS FOR CAUTION Only English-language studies, published between 2000 and 2021, found in the above-mentioned databases were considered for this review. WIDER IMPLICATIONS OF THE FINDINGS More research is necessary to understand the risks and benefits of building a family at an advanced parental age for the offspring when they reach adulthood. Furthermore, studies that explore the perspective of older fathers and older parents from non-Western societies would be highly informative. STUDY FUNDING/COMPETING INTEREST(S) The writing of this manuscript was permitted by financial support provided by the Swiss National Science Foundation (Weave/Lead Agency funding program, grant number 10001AL_197415/1, project title ‘Family Building at Advanced Parental Age: An Interdisciplinary Approach’). The funder had no role in the drafting of this manuscript and the views expressed therein are those of the authors. The authors have no conflicts of interest. REGISTRATION NUMBER This systematic review is registered in Prospero: CRD42022304564.

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“…The prevalence of ASD in several Asian and American countries is the United States (90 per 10 000), South Asia (1 in 93), Japan (13 per 10 000), and China (9,8 per 10 000). (25)…”

Section: Research Developments Per Yearmentioning

confidence: 99%

Bibliometric Mapping of Trends of Project-Based Learning with Augmented Reality on Communication Ability of Children with Special Needs (Autism)

Munir,

Al Husaeni,

Rasim

et al. 2024

Data and Metadata

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This study aims to analyze the use of project-based learning with augmented reality (AR) on the communication skills of autistic children through systematic literature review and theoretical bibliometric analysis of research on autistic children's communication skills sourced from Scopus from 2013 to 2022. The research method is a systematic literature review with analysis theory and bibliometric analysis with VOSviewer and RStudio applications. This research was conducted in several stages, namely determining i) research questions; ii) inclusion and exclusion criteria; iii) quality assessment; iv) data collection; and v) bibliometric analysis. The results of this study note that research on the communication skills of autistic children is still a research trend that is of great interest to researchers with an increase in research occurring from 2015 to 2022. Countries from the Americas and Asia have contributed the most to research on the communication skills of autistic children. The subject areas of psychology and social science are the subject areas with the most contributions, namely 22% each of the 165 articles found. There is a relationship between the term project (P), communication skills (CS), and autism spectrum disorder (ASD). This relationship is shown by the link strength P→CS is 2 and the link strength CS→ASD is 4. The characteristic requirements for autistic children for project-based learning with AR are middle class autistic children. The characteristics possessed by project-based learning can help in training the level of communication skills of autistic children and it would be better if assisted with the use of AR.

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Advanced parental age and risk of positive autism spectrum disorders screening

Cited by 14 publications

References 28 publications

Autistic traits in offspring of schizophrenic patients in comparison to those of normal population: a case-control study

Autistic traits in offspring of schizophrenic patients in comparison to those of normal population: a case-control study

Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring

Bibliometric Mapping of Trends of Project-Based Learning with Augmented Reality on Communication Ability of Children with Special Needs (Autism)

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