Advanced Parental Age at Birth Is Associated With Poorer Social Functioning in Adolescent Males: Shedding Light on a Core Symptom of Schizophrenia and Autism

Weiser, Mark; Reichenberg, Abraham; Werbeloff, Nomi; Kleinhaus, Karine; Lubin, Gad; Shmushkevitch, M; Caspi, Asaf; Malaspina, Dolores; Davidson, Michael

doi:10.1093/schbul/sbn109

Cited by 67 publications

(59 citation statements)

References 36 publications

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“…Navorsingsresultate wat verband hou met sosiale funksionering in die algemene bevolking en gevorderde vaderlike ouderdom, stel voor dat die risiko tussen gevorderderde vaderlike ouderdom en skisofrenie minstens gedeeltelik 'n nadelige effek van sosiale funksionering insluit (Liebenberg et al 2016;Weiser et al 2008). …”

Section: Vaderlike Ouderdomsverwante Skisofrenie (Vovs) En Sosiale Fuunclassified

“…Hierdie faktore kan ook bydra tot die manifestasies van ander psigiatriese toestande of intermediêre fenotipes soos ingekorte kognitiewe of sosiale funksionering. Die nadelige effek van die risikofaktore manifesteer as psigiatriese steurnis (skisofrenie) wanneer individue 'n sekere ernstigheidsdrempel oorskry (Weiser et al 2008). Gevolglik hoef gevorderderde vaderlike ouderdom nie noodwendig 'n risikofaktor vir 'n spesifieke psigiatriese steurnis soos skisofrenie te wees nie.…”

Section: Vaderlike Ouderdomsverwante Skisofrenie (Vovs) En Sosiale Fuunclassified

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Van laboratoriumbank tot siekbed: Genetiese bevindings in skisofrenie

Roos

2017

Suid-Afrikaanse Tydskr Natuurwetenskap Tegnol

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Die genetiese argitektuur van skisofrenie is bewys kompleks te wees. Die debat oor die kompleksiteit fokus op die relatiewe belang van twee kontrasterende (maar konseptueel verbandhoudende) hipoteses: die algemene siekte-of algemene alleelmodel (ASAA) en die algemene siekte-of unieke alleelmodel (ASUA). Die ASAA-model stel voor dat die genetiese risiko in 'n individu en bevolking veroorsaak word deur te veel hoëfrekwensie-variante, wat elk 'n magtige vlak van risiko bydra (McClellan & King 2010;Risch & Merikangas 1996).In kontras stel die ASUA-model voor dat die genetiese risiko in 'n individu verklaar word deur skaars mutasies wat 'n beduidende bydrae lewer. Gevolglik kan die algemene siekte dalk dui op 'n groot aantal (honderde of duisende) verskillende oorsake, met 'n lae frekwensie (tipies minder as 1/1000 individue), maar wat bydra tot 'n groot deel van die bydraende risiko van die gemiddelde.Die skaars kopie-nommervariante (KNV'e) wat 'n bydrae lewer met 'n hoër risiko om siekte te veroorsaak in die genoom is óf spontaan óf word oorgedra aan nasate. KNV'e is skaars, maar Die komplekse genetiese argitektuur van skisofrenie word kortliks omskryf deur na twee kontrasterende (maar konseptueel verbandhoudende) hipoteses te verwys. Bevindings van die lokus van genoomwye assosiasiestudies (GWAS) en die majorhistoversoenbaarheidskompleks (MHK) op chromosoom 6 en skisofrenie word aangehaal. Klassieke aanvullingskaskade verbonde hieraan word betrek in die eliminering, of 'snoei van sinapse' as deel van die patogenese van skisofrenie. Daar word nader aan die siekbed van skisofreniepasiënte beweeg deur te kyk na die volgende navorsingsbevindings in pasiënte met skisofrenie in die Afrikanerbevolking:• mikro-uitwissing by die 22q11.2 chromosoom as 'n spesifieke tipe skisofrenie;• fenotipiese kenmerke van skisofreniepasiënte wat spontane geenmutasies dra;• skisofrenie wat verwant is aan die vaderlike ouderdom (VOVS) en sosiale funksionering vroeg en later in die lewe van die pasiënte; • verhoogde selfdoodrisiko in skisofreniepasiënte met koppeling aan chromosoom 13q en hoe mortaliteit in die pasiënte verlaag kan word. Van laboratoriumbank tot siekbed: Genetiese bevindings in skisofrenieRead online:Scan this QR code with your smart phone or mobile device to read online. From laboratory to the bedside: Genetic findings in schizophrenia.The complex genetic architecture of schizophrenia is briefly described with reference to two contrasting (but conceptually related) hypotheses. There is reference to genome-wide association studies (GWAS) and the major histocompatibility complex (MHC) locus on chromosome 6 and schizophrenia. Recent findings regarding structural alleles in the classical complement cascade, related to the MHC and implicated in the elimination and 'pruning of synapses', form part of the pathogenesis of schizophrenia. Moving closer to the bedside of schizophrenia patients, the following research findings in the Afrikaner population are discussed:• micro deletion at 22q11.2 chromosome as a specific subtype of sch...

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Section: Vaderlike Ouderdomsverwante Skisofrenie (Vovs) En Sosiale Fuunclassified

Van laboratoriumbank tot siekbed: Genetiese bevindings in skisofrenie

Roos

2017

Suid-Afrikaanse Tydskr Natuurwetenskap Tegnol

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“…Studies suggest that parental age at the time of conception or birth increases the risk of a child being diagnosed with ASD and other communication and neurodevelopmental disorders (e.g., Croen et al 2007;Durkin et al 2008;Frans et al 2013;Grether et al 2009;Hultman et al 2011;King et al 2009;Lundstrom et al 2010;Merikangas et al 2016;Reichenberg et al 2006;Sandin et al 2012Sandin et al , 2016Saha et al 2009;van Balkom et al 2012;Weiser et al 2008). In particular, advanced paternal age has been implicated in a higher risk of having a child with ASD (e.g., Shimada et al 2012), and both younger and older mothers have an increased risk for having a child with a CD (Silva et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Autism Spectrum Disorders and Communication Disorders: Influences of Advanced Parental Age and Use of Assisted Reproductive Technology

Kamowski-Shakibai

Kollia

Magaldi

2017

Adv Neurodev Disord

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Research suggests that two prenatal factors, advanced parental age and use of assisted reproductive technology (ART), may independently increase the likelihood for the development of autism spectrum disorder (ASD) and other neurodevelopmental disorders. Our study evaluated the effect of advanced maternal and paternal ages (i.e., ages 35 and over) at the time of conception with and without the use of ART on the incidence of ASD and communication disorders (CD). We hypothesized that advanced parental age would be the strongest independent risk factor for the incidence of ASD and/or CD in offspring compared to younger parental age and use of ART. Information on 122 children was obtained through confidential survey. Parental ages at time of conception, diagnoses, use of ART, and infertility were considered. Results indicated that the risk of having a child with a CD increased significantly with either advanced maternal or paternal age. The risk of having a child diagnosed with ASD and/or CD was significantly higher for couples of advanced age, and the risk was significantly decreased for younger couples. Mothers of advanced age used ART at a significantly higher rate; however, this risk of having a child diagnosed with ASD and/or CD was not increased. Identification of risk factors (particularly combinations of risk factors) is essential for early detection of ASD and CD. The findings of our study, combined with other epidemiological data, may help to guide the development of prenatal screening tools and procedures. Implications are discussed.

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“…Research results of social functioning studies in the general population and advanced paternal age suggest that the risk pathways between advanced paternal age and schizophrenia, at least partially, include mildly deleterious effects of social functioning (Weiser et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Deleterious effects of the risk factors are manifested as mental illness only when individuals cross a certain severity threshold (Weiser et al, 2008). Thus, advanced paternal age might not be a risk factor for a specific mental disorder such as schizophrenia, but rather increases the risk for brain malfunction that rarely crosses the threshold for a clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%